CFA73_HUMAN
ID CFA73_HUMAN Reviewed; 308 AA.
AC A6NFT4;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 11-JAN-2011, sequence version 3.
DT 03-AUG-2022, entry version 84.
DE RecName: Full=Cilia- and flagella-associated protein 73 {ECO:0000305};
DE AltName: Full=Coiled-coil domain-containing protein 42B {ECO:0000312|HGNC:HGNC:37100};
GN Name=CFAP73 {ECO:0000312|HGNC:HGNC:37100};
GN Synonyms=CCDC42B {ECO:0000312|HGNC:HGNC:37100};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 9-103.
RA Stevens M., Wei C., Gross S.S., McPherson J., Brent M.R.;
RT "Exhaustive RT-PCR and sequencing of all novel TWINSCAN predictions in
RT human.";
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May play a role in ciliary/flagellar motility by regulating
CC the assembly and the activity of axonemal inner dynein arm.
CC {ECO:0000250|UniProtKB:M1V4Y8}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:M1V4Y8}.
CC -!- SIMILARITY: Belongs to the CFAP73 family. {ECO:0000305}.
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DR EMBL; AC089999; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; EG327787; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS44983.1; -.
DR RefSeq; NP_001138344.1; NM_001144872.1.
DR AlphaFoldDB; A6NFT4; -.
DR SMR; A6NFT4; -.
DR IntAct; A6NFT4; 1.
DR MINT; A6NFT4; -.
DR STRING; 9606.ENSP00000333915; -.
DR BioMuta; CFAP73; -.
DR jPOST; A6NFT4; -.
DR MassIVE; A6NFT4; -.
DR PaxDb; A6NFT4; -.
DR PeptideAtlas; A6NFT4; -.
DR PRIDE; A6NFT4; -.
DR ProteomicsDB; 1076; -.
DR Antibodypedia; 62409; 25 antibodies from 8 providers.
DR DNASU; 387885; -.
DR Ensembl; ENST00000335621.11; ENSP00000333915.6; ENSG00000186710.12.
DR GeneID; 387885; -.
DR KEGG; hsa:387885; -.
DR MANE-Select; ENST00000335621.11; ENSP00000333915.6; NM_001144872.3; NP_001138344.1.
DR UCSC; uc010sys.2; human.
DR CTD; 387885; -.
DR GeneCards; CFAP73; -.
DR HGNC; HGNC:37100; CFAP73.
DR HPA; ENSG00000186710; Tissue enhanced (brain, choroid plexus, fallopian tube).
DR neXtProt; NX_A6NFT4; -.
DR OpenTargets; ENSG00000186710; -.
DR VEuPathDB; HostDB:ENSG00000186710; -.
DR eggNOG; ENOG502QRZS; Eukaryota.
DR GeneTree; ENSGT00940000153110; -.
DR HOGENOM; CLU_061472_3_0_1; -.
DR InParanoid; A6NFT4; -.
DR OMA; SIEMLYI; -.
DR OrthoDB; 1528754at2759; -.
DR PhylomeDB; A6NFT4; -.
DR TreeFam; TF327270; -.
DR PathwayCommons; A6NFT4; -.
DR SignaLink; A6NFT4; -.
DR BioGRID-ORCS; 387885; 7 hits in 1064 CRISPR screens.
DR ChiTaRS; CFAP73; human.
DR GenomeRNAi; 387885; -.
DR Pharos; A6NFT4; Tdark.
DR PRO; PR:A6NFT4; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; A6NFT4; protein.
DR Bgee; ENSG00000186710; Expressed in right uterine tube and 145 other tissues.
DR ExpressionAtlas; A6NFT4; baseline and differential.
DR Genevisible; A6NFT4; HS.
DR GO; GO:0097545; C:axonemal outer doublet; ISS:UniProtKB.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR InterPro; IPR025252; DUF4200.
DR Pfam; PF13863; DUF4200; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..308
FT /note="Cilia- and flagella-associated protein 73"
FT /id="PRO_0000343715"
FT COILED 34..143
FT /evidence="ECO:0000255"
FT COILED 175..233
FT /evidence="ECO:0000255"
SQ SEQUENCE 308 AA; 35914 MW; BB0972AFC8C8B077 CRC64;
MAVPWEEYFR LALQEKLSTK LPEQAEDHVP PVLRLLEKRQ ELVDADQALQ AQKEVFRTKT
AALKQRWEQL EQKERELKGS FIRFDKFLQD SEARRNRALR RAAEERHQAG RREVEALRLW
TQLQELRREH ARLQRRLKRL EPCARLLEQA LELLPGFQEV PELVARFDGL AETQAALRLR
EREQLAELEA ARARLQQLRD AWPDEVLAQG QRRAQLQERL EAARERTLQW ESKWIQIQNT
AAEKTLLLGR SRMAVLNLFQ LVCQHQGQPP TLDIEDTEGQ LEHVKLFMQD LSAMLAGLGQ
AEPAAPAS
