ID   CFA73_MOUSE             Reviewed;         306 AA.
AC   J3QPZ5;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Cilia- and flagella-associated protein 73 {ECO:0000305};
DE   AltName: Full=Coiled-coil domain-containing protein 42B {ECO:0000312|MGI:MGI:3779542};
GN   Name=Cfap73 {ECO:0000312|MGI:MGI:3779542};
GN   Synonyms=Ccdc42b {ECO:0000312|MGI:MGI:3779542};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- FUNCTION: May play a role in ciliary/flagellar motility by regulating
CC       the assembly and the activity of axonemal inner dynein arm.
CC       {ECO:0000250|UniProtKB:M1V4Y8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, cilium axoneme
CC       {ECO:0000250|UniProtKB:M1V4Y8}.
CC   -!- SIMILARITY: Belongs to the CFAP73 family. {ECO:0000305}.
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DR   EMBL; AC125183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS57376.1; -.
DR   RefSeq; NP_001182023.1; NM_001195094.1.
DR   AlphaFoldDB; J3QPZ5; -.
DR   SMR; J3QPZ5; -.
DR   STRING; 10090.ENSMUSP00000137554; -.
DR   MaxQB; J3QPZ5; -.
DR   PaxDb; J3QPZ5; -.
DR   PRIDE; J3QPZ5; -.
DR   ProteomicsDB; 281393; -.
DR   Antibodypedia; 62409; 25 antibodies from 8 providers.
DR   Ensembl; ENSMUST00000177908; ENSMUSP00000137554; ENSMUSG00000094282.
DR   GeneID; 546886; -.
DR   KEGG; mmu:546886; -.
DR   UCSC; uc012ecs.1; mouse.
DR   CTD; 387885; -.
DR   MGI; MGI:3779542; Cfap73.
DR   VEuPathDB; HostDB:ENSMUSG00000094282; -.
DR   eggNOG; ENOG502QRZS; Eukaryota.
DR   GeneTree; ENSGT00940000153110; -.
DR   HOGENOM; CLU_061472_3_0_1; -.
DR   InParanoid; J3QPZ5; -.
DR   OMA; SIEMLYI; -.
DR   OrthoDB; 1528754at2759; -.
DR   PhylomeDB; J3QPZ5; -.
DR   TreeFam; TF327270; -.
DR   BioGRID-ORCS; 546886; 2 hits in 40 CRISPR screens.
DR   PRO; PR:J3QPZ5; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; J3QPZ5; protein.
DR   Bgee; ENSMUSG00000094282; Expressed in spermatid and 19 other tissues.
DR   GO; GO:0097545; C:axonemal outer doublet; ISS:UniProtKB.
DR   GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR   InterPro; IPR025252; DUF4200.
DR   Pfam; PF13863; DUF4200; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Reference proteome.
FT   CHAIN           1..306
FT                   /note="Cilia- and flagella-associated protein 73"
FT                   /id="PRO_0000437481"
FT   COILED          49..139
FT                   /evidence="ECO:0000255"
FT   COILED          197..231
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   306 AA;  35671 MW;  152E0FF0C7B831DA CRC64;
     MAVTWEEYFR LVFSEKVQPK PLEQTGDDSS VLQLILEKKE ELAVADLGLQ AQKKEYRSTI
     ESVNQRWREL EQKGQELQGS VISYDKFLKE VEARRAARKA IEERKITGNL DAELRRLRTQ
     LKELRLQRAR LQRKVQRLEP CARILKRALE KRPVFEEVSD LVARFETLVS TKAALKLEEQ
     KRLVEMESTR AQLLSLQSEK QDEMLNLNQQ RTQLVEQLEA AREHRQQWES KWTEILNSAS
     EKTLLLGRAR MAVLNLYHLV RLQQGRRQTL DVRDVEGQLE EVKRFIMNIS ATLAKLALAQ
     PTATAS