CFA91_CHLRE
ID CFA91_CHLRE Reviewed; 1029 AA.
AC A8IH47;
DT 12-APR-2017, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 1.
DT 03-AUG-2022, entry version 53.
DE RecName: Full=Cilia- and flagella-associated protein 91 {ECO:0000305};
DE AltName: Full=Flagellar-associated protein 91 {ECO:0000305};
GN Name=CFAP91 {ECO:0000305}; Synonyms=FAP91 {ECO:0000303|PubMed:17967944};
GN ORFNames=CHLREDRAFT_196748 {ECO:0000312|EMBL:EDP05695.1};
OS Chlamydomonas reinhardtii (Chlamydomonas smithii).
OC Eukaryota; Viridiplantae; Chlorophyta; core chlorophytes; Chlorophyceae;
OC CS clade; Chlamydomonadales; Chlamydomonadaceae; Chlamydomonas.
OX NCBI_TaxID=3055;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CC-503;
RX PubMed=17932292; DOI=10.1126/science.1143609;
RA Merchant S.S., Prochnik S.E., Vallon O., Harris E.H., Karpowicz S.J.,
RA Witman G.B., Terry A., Salamov A., Fritz-Laylin L.K., Marechal-Drouard L.,
RA Marshall W.F., Qu L.H., Nelson D.R., Sanderfoot A.A., Spalding M.H.,
RA Kapitonov V.V., Ren Q., Ferris P., Lindquist E., Shapiro H., Lucas S.M.,
RA Grimwood J., Schmutz J., Cardol P., Cerutti H., Chanfreau G., Chen C.L.,
RA Cognat V., Croft M.T., Dent R., Dutcher S., Fernandez E., Fukuzawa H.,
RA Gonzalez-Ballester D., Gonzalez-Halphen D., Hallmann A., Hanikenne M.,
RA Hippler M., Inwood W., Jabbari K., Kalanon M., Kuras R., Lefebvre P.A.,
RA Lemaire S.D., Lobanov A.V., Lohr M., Manuell A., Meier I., Mets L.,
RA Mittag M., Mittelmeier T., Moroney J.V., Moseley J., Napoli C.,
RA Nedelcu A.M., Niyogi K., Novoselov S.V., Paulsen I.T., Pazour G.J.,
RA Purton S., Ral J.P., Riano-Pachon D.M., Riekhof W., Rymarquis L.,
RA Schroda M., Stern D., Umen J., Willows R., Wilson N., Zimmer S.L.,
RA Allmer J., Balk J., Bisova K., Chen C.J., Elias M., Gendler K., Hauser C.,
RA Lamb M.R., Ledford H., Long J.C., Minagawa J., Page M.D., Pan J.,
RA Pootakham W., Roje S., Rose A., Stahlberg E., Terauchi A.M., Yang P.,
RA Ball S., Bowler C., Dieckmann C.L., Gladyshev V.N., Green P., Jorgensen R.,
RA Mayfield S., Mueller-Roeber B., Rajamani S., Sayre R.T., Brokstein P.,
RA Dubchak I., Goodstein D., Hornick L., Huang Y.W., Jhaveri J., Luo Y.,
RA Martinez D., Ngau W.C., Otillar B., Poliakov A., Porter A., Szajkowski L.,
RA Werner G., Zhou K., Grigoriev I.V., Rokhsar D.S., Grossman A.R.;
RT "The Chlamydomonas genome reveals the evolution of key animal and plant
RT functions.";
RL Science 318:245-250(2007).
RN [2]
RP FUNCTION, IDENTIFICATION IN A COMPLEX CONTAINING CFAP61; CFAP91 AND
RP CFAP251, SUBCELLULAR LOCATION, INTERACTION WITH RSP3, AND INTERACTION WITH
RP CALMODULIN.
RX PubMed=17967944; DOI=10.1083/jcb.200703107;
RA Dymek E.E., Smith E.F.;
RT "A conserved CaM- and radial spoke associated complex mediates regulation
RT of flagellar dynein activity.";
RL J. Cell Biol. 179:515-526(2007).
CC -!- FUNCTION: As component of a spoke-associated complex, regulates
CC flagellar dynein activity by mediating regulatory signals between the
CC radial spokes and dynein arms. {ECO:0000269|PubMed:17967944}.
CC -!- SUBUNIT: Identified in a spoke-associated complex containing CFAP61,
CC CFAP91 and CFAP251; the complex is associated with the radial spokes of
CC the axoneme (PubMed:17967944). The complex associates with Calmodulin;
CC the association is calcium sensitive (PubMed:17967944). Interacts with
CC RSP3 (PubMed:17967944). {ECO:0000269|PubMed:17967944}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000269|PubMed:17967944}.
CC -!- SIMILARITY: Belongs to the CFAP91 family.
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DR EMBL; DS496117; EDP05695.1; -; Genomic_DNA.
DR RefSeq; XP_001690436.1; XM_001690384.1.
DR AlphaFoldDB; A8IH47; -.
DR STRING; 3055.EDP05695; -.
DR PaxDb; A8IH47; -.
DR PRIDE; A8IH47; -.
DR EnsemblPlants; PNW80814; PNW80814; CHLRE_07g330700v5.
DR GeneID; 5716169; -.
DR Gramene; PNW80814; PNW80814; CHLRE_07g330700v5.
DR eggNOG; ENOG502QRFI; Eukaryota.
DR HOGENOM; CLU_294633_0_0_1; -.
DR InParanoid; A8IH47; -.
DR OrthoDB; 707324at2759; -.
DR GO; GO:0005930; C:axoneme; IDA:UniProtKB.
DR GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR GO; GO:0003341; P:cilium movement; IDA:UniProtKB.
DR InterPro; IPR026720; CFAP91.
DR InterPro; IPR032840; CFAP91_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR PANTHER; PTHR22455; PTHR22455; 1.
DR Pfam; PF14738; CFAP91; 1.
DR Pfam; PF00612; IQ; 2.
DR SMART; SM00015; IQ; 3.
DR PROSITE; PS50096; IQ; 2.
PE 1: Evidence at protein level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton; Flagellum.
FT CHAIN 1..1029
FT /note="Cilia- and flagella-associated protein 91"
FT /id="PRO_0000439535"
FT REGION 72..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 117..170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 837..861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 876..1029
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 272..299
FT /evidence="ECO:0000255"
FT COMPBIAS 838..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 894..908
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 980..998
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1029 AA; 107241 MW; BDEB18B8FCC4906E CRC64;
MAQPQRPYDA LYDPNFTVAG PRDHYRQQTM AGGFNIERAP VYNNFFSELP HHPPSTLRLK
NADRVPAFVD RNYRPAANDP NDTRQRSDAL AVSGPNRPKY FRRPMLAAAE IHIKQAPPSQ
LPPLPSHQDL NATAPAAMGG AGGLGEPRSK TIGTQSDYRE NEAQTAPWEP GYVLPAPGAL
TAKQAALMRR YHTDVPEVLQ LKDLAFPDGL PAGLQEVTRI DKMRAKRAFE ASLPPIDDVA
RLPLRQRMIE EWEAKEWEER EQEILSIQDK RLELLDNALQ VREEELDDEN RLRVEARKEA
MLAGRAGKFA DVQATRIKTM RQLIENRKYV EKHRKLHKPT IVERYANYGS GTYAPLQREG
RFPESKPLGK EIETEGYAPV TLKGVVDLES FLPSRLLNPR VAAPQKPARL DYHQRKEAAV
QRDLKAINDL LDTAKGTAGR GFGDCWPAPL QDDGGAGMGN GTLGRATSTV GKGTLGAGGS
AGGAAPGGAS MALLGGPSTA AASAMGPLAS GVSGSPSRRV VRAIERPPTP ELPQPPAVTA
PQHAAVVLLQ RLLRGRAAQN IMYEGRVRRQ ELIDELRLEE VVSADGTKID GQPIRRPEHR
DTATLRIDAL VGSAVAEVAA ILAETDPERR ETLLAGLDVS RAHATAAAVA AAAADINASA
RAEAEEAAAT AMAEAAAAAA AAAAAAAAAE DGGAEGAAES AAEAAAAAEA AASAAEEAYA
GAVAAAAAPA RAAALNLEAL GISPEEAEEA AVRIQAAFKG HKARKEVAAM RARGEMLRNI
MANGDEAKVV TCQAAIRGHL ARKRVRQLRA SQAGNEGFAG APSASPEPAA PLPALAENQD
QQEPQPQPQP SSSSGALDLA DYDDHHGEAS AAMLGGEPSL AVGGSREGEQ QLEADAEAEA
EAEAEAEAGA EAEASAQAGA EAEAEAGVEA EAEASAGAEA SVGAGAEGDA EAETEAGAQA
EPGPEAEAEA EAGAEAEAEN GAEAEARLGG EEEGFREGEG QGGAAAGEAG PGGELAEGEG
EAGEGEAAE
