CFA91_HUMAN
ID CFA91_HUMAN Reviewed; 767 AA.
AC Q7Z4T9; A0AVK2; A8K1J9; B3KP23; B4DG52; B4DZ14; C9JUG4; Q68DX2; Q8TD41;
AC Q96A45; Q96JE8;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Cilia- and flagella-associated protein 91 {ECO:0000305};
DE Short=CFAP91 {ECO:0000305};
DE AltName: Full=AMY-1-associating protein expressed in testis 1 {ECO:0000303|PubMed:15863901};
DE Short=AAT-1 {ECO:0000303|PubMed:15863901};
DE AltName: Full=MYCBP/AMY-1-associated testis-expressed protein 1 {ECO:0000303|PubMed:12223483};
DE AltName: Full=Protein MAATS1 {ECO:0000303|PubMed:12223483};
GN Name=CFAP91 {ECO:0000312|HGNC:HGNC:24010};
GN Synonyms=AAT1 {ECO:0000303|PubMed:15863901}, C3orf15, MAATS1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), NUCLEOTIDE SEQUENCE [MRNA] OF
RP 617-767 (ISOFORM 7), FUNCTION, INTERACTION WITH MYCBP AND AKAP1,
RP PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RC TISSUE=Testis;
RX PubMed=12223483; DOI=10.1074/jbc.m206201200;
RA Yukitake H., Furusawa M., Taira T., Iguchi-Ariga S.M.M., Ariga H.;
RT "AAT-1, a novel testis-specific AMY-1-binding protein, forms a quaternary
RT complex between AMY-1, A-kinase anchor protein 84 and a regulatory subunit
RT of cAMP-dependent protein kinase and is phosphorylated by its kinase.";
RL J. Biol. Chem. 277:45480-45492(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP PRO-207.
RC TISSUE=Lung;
RA Guo J.H., Yu L.;
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 6; 7 AND 8), AND VARIANT
RP PRO-207.
RC TISSUE=Amygdala, Corpus callosum, Lung, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND VARIANT PRO-207.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16641997; DOI=10.1038/nature04728;
RA Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O.,
RA Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X.,
RA Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT "The DNA sequence, annotation and analysis of human chromosome 3.";
RL Nature 440:1194-1198(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 7), AND VARIANT PRO-207.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP ALTERNATIVE SPLICING, INTERACTION WITH MYCBP, TISSUE SPECIFICITY (ISOFORM
RP 1), SUBCELLULAR LOCATION (ISOFORM 7), AND SUBCELLULAR LOCATION.
RX PubMed=15863901; DOI=10.1248/bpb.28.898;
RA Matsuda E., Ishizaki R., Taira T., Iguchi-Ariga S.M.M., Ariga H.;
RT "Structure and characterization of AAT-1 isoforms.";
RL Biol. Pharm. Bull. 28:898-901(2005).
RN [8]
RP INVOLVEMENT IN SPGF51, AND FUNCTION.
RX PubMed=32161152; DOI=10.1136/jmedgenet-2019-106775;
RA Martinez G., Beurois J., Dacheux D., Cazin C., Bidart M., Kherraf Z.E.,
RA Robinson D.R., Satre V., Le Gac G., Ka C., Gourlaouen I., Fichou Y.,
RA Petre G., Dulioust E., Zouari R., Thierry-Mieg N., Toure A., Arnoult C.,
RA Bonhivers M., Ray P., Coutton C.;
RT "Biallelic variants in MAATS1 encoding CFAP91, a calmodulin-associated and
RT spoke-associated complex protein, cause severe astheno-teratozoospermia and
RT male infertility.";
RL J. Med. Genet. 57:708-716(2020).
CC -!- FUNCTION: Involved in sperm flagellum axonemal organization and
CC function (PubMed:12223483, PubMed:32161152). May regulate cilium
CC motility through its role in the assembly of the axonemal radial spokes
CC (By similarity). {ECO:0000250|UniProtKB:A8IH47,
CC ECO:0000269|PubMed:12223483, ECO:0000269|PubMed:32161152}.
CC -!- SUBUNIT: Interacts with MYCBP and AKAP1. Part of a complex containing
CC MYCBP, AKAP1 and PRKAR2B. {ECO:0000269|PubMed:12223483,
CC ECO:0000269|PubMed:15863901}.
CC -!- SUBUNIT: [Isoform 3]: Does not interact with MYCBP.
CC {ECO:0000269|PubMed:15863901}.
CC -!- INTERACTION:
CC Q7Z4T9; Q9C005: DPY30; NbExp=3; IntAct=EBI-2119657, EBI-744973;
CC Q7Z4T9-3; Q92667-2: AKAP1; NbExp=3; IntAct=EBI-17172567, EBI-2120060;
CC Q7Z4T9-3; Q99417: MYCBP; NbExp=5; IntAct=EBI-17172567, EBI-716185;
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:12223483,
CC ECO:0000269|PubMed:15863901}. Cytoplasm {ECO:0000269|PubMed:12223483,
CC ECO:0000269|PubMed:15863901}. Cytoplasm, cytoskeleton, cilium axoneme
CC {ECO:0000250|UniProtKB:A8IH47}. Note=Localized in the neck of the
CC sperm.
CC -!- SUBCELLULAR LOCATION: [Isoform 7]: Cytoplasm
CC {ECO:0000269|PubMed:15863901}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative promoter usage, Alternative splicing; Named isoforms=7;
CC Comment=Additional isoforms may exist.;
CC Name=7; Synonyms=AAT-1L {ECO:0000303|PubMed:15863901};
CC IsoId=Q7Z4T9-7; Sequence=Displayed;
CC Name=1; Synonyms=AAT-1M {ECO:0000303|PubMed:15863901};
CC IsoId=Q7Z4T9-1; Sequence=VSP_059500;
CC Name=2;
CC IsoId=Q7Z4T9-2; Sequence=VSP_014910, VSP_014911;
CC Name=3;
CC IsoId=Q7Z4T9-3; Sequence=VSP_014907;
CC Name=6;
CC IsoId=Q7Z4T9-6; Sequence=VSP_039503;
CC Name=8;
CC IsoId=Q7Z4T9-8; Sequence=VSP_039504;
CC Name=5; Synonyms=AAT1-beta {ECO:0000303|PubMed:15863901};
CC IsoId=Q7Z4T9-5; Sequence=VSP_059499;
CC -!- TISSUE SPECIFICITY: [Isoform 1]: Strongly expressed in the liver.
CC -!- TISSUE SPECIFICITY: [Isoform 7]: Widely expressed, but strongly
CC expressed in all spermatogenesis-related tissues, including the testis,
CC the epithelium of cauda and the corpus epididymis, as well as the
CC spermatid and mature sperm. Also expressed in Leydig cells.
CC {ECO:0000269|PubMed:15863901, ECO:0000269|PubMed:32161152}.
CC -!- PTM: Phosphorylated by PKA. {ECO:0000269|PubMed:12223483}.
CC -!- DISEASE: Spermatogenic failure 51 (SPGF51) [MIM:619177]: An autosomal
CC recessive infertility disorder characterized by
CC asthenoteratozoospermia. Spermatozoa exhibit multiple morphologic
CC abnormalities, including absent, short, bent, coiled and irregular-
CC caliber flagella. Abnormalities of the sperm head, base, and acrosome
CC have also been observed. {ECO:0000269|PubMed:32161152}. Note=The
CC disease is caused by variants affecting the gene represented in this
CC entry.
CC -!- MISCELLANEOUS: [Isoform 5]: May be produced by alternative promoter
CC usage. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the CFAP91 family.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB60902.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB063296; BAB60902.1; ALT_INIT; mRNA.
DR EMBL; AB063297; BAB60903.1; -; mRNA.
DR EMBL; AB063298; BAB60904.1; -; mRNA.
DR EMBL; AF440403; AAP97317.1; -; mRNA.
DR EMBL; AF497717; AAM19218.1; -; mRNA.
DR EMBL; AK055558; BAG51535.1; -; mRNA.
DR EMBL; AK289914; BAF82603.1; -; mRNA.
DR EMBL; AK294413; BAG57663.1; -; mRNA.
DR EMBL; AK302699; BAG63926.1; -; mRNA.
DR EMBL; CR749242; CAH18098.1; -; mRNA.
DR EMBL; AC117466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC069444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC126394; AAI26395.1; -; mRNA.
DR CCDS; CCDS2994.1; -. [Q7Z4T9-7]
DR RefSeq; NP_001307245.1; NM_001320316.1.
DR RefSeq; NP_001307246.1; NM_001320317.1. [Q7Z4T9-3]
DR RefSeq; NP_001307247.1; NM_001320318.1. [Q7Z4T9-6]
DR RefSeq; NP_203528.2; NM_033364.3. [Q7Z4T9-7]
DR RefSeq; XP_011511579.1; XM_011513277.1. [Q7Z4T9-6]
DR AlphaFoldDB; Q7Z4T9; -.
DR SMR; Q7Z4T9; -.
DR BioGRID; 124630; 7.
DR IntAct; Q7Z4T9; 6.
DR STRING; 9606.ENSP00000273390; -.
DR iPTMnet; Q7Z4T9; -.
DR PhosphoSitePlus; Q7Z4T9; -.
DR BioMuta; MAATS1; -.
DR DMDM; 300669603; -.
DR MassIVE; Q7Z4T9; -.
DR PaxDb; Q7Z4T9; -.
DR PeptideAtlas; Q7Z4T9; -.
DR PRIDE; Q7Z4T9; -.
DR ProteomicsDB; 69234; -. [Q7Z4T9-1]
DR ProteomicsDB; 69235; -. [Q7Z4T9-2]
DR ProteomicsDB; 69236; -. [Q7Z4T9-3]
DR ProteomicsDB; 69238; -. [Q7Z4T9-5]
DR ProteomicsDB; 69239; -. [Q7Z4T9-6]
DR ProteomicsDB; 69240; -. [Q7Z4T9-7]
DR ProteomicsDB; 69241; -. [Q7Z4T9-8]
DR Antibodypedia; 32764; 133 antibodies from 16 providers.
DR DNASU; 89876; -.
DR Ensembl; ENST00000273390.9; ENSP00000273390.5; ENSG00000183833.16. [Q7Z4T9-7]
DR Ensembl; ENST00000463700.1; ENSP00000419489.1; ENSG00000183833.16. [Q7Z4T9-2]
DR GeneID; 89876; -.
DR KEGG; hsa:89876; -.
DR MANE-Select; ENST00000273390.9; ENSP00000273390.5; NM_033364.4; NP_203528.3.
DR UCSC; uc003edc.3; human. [Q7Z4T9-7]
DR CTD; 89876; -.
DR DisGeNET; 89876; -.
DR GeneCards; CFAP91; -.
DR HGNC; HGNC:24010; CFAP91.
DR HPA; ENSG00000183833; Tissue enhanced (fallopian).
DR MalaCards; CFAP91; -.
DR MIM; 609910; gene.
DR MIM; 619177; phenotype.
DR neXtProt; NX_Q7Z4T9; -.
DR OpenTargets; ENSG00000183833; -.
DR VEuPathDB; HostDB:ENSG00000183833; -.
DR eggNOG; ENOG502QRFI; Eukaryota.
DR GeneTree; ENSGT00390000003024; -.
DR HOGENOM; CLU_011633_0_0_1; -.
DR InParanoid; Q7Z4T9; -.
DR OMA; HLNAQWS; -.
DR OrthoDB; 496618at2759; -.
DR PhylomeDB; Q7Z4T9; -.
DR TreeFam; TF328648; -.
DR PathwayCommons; Q7Z4T9; -.
DR SignaLink; Q7Z4T9; -.
DR BioGRID-ORCS; 89876; 12 hits in 1076 CRISPR screens.
DR ChiTaRS; MAATS1; human.
DR GeneWiki; C3orf15; -.
DR GenomeRNAi; 89876; -.
DR Pharos; Q7Z4T9; Tbio.
DR PRO; PR:Q7Z4T9; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q7Z4T9; protein.
DR Bgee; ENSG00000183833; Expressed in right uterine tube and 153 other tissues.
DR ExpressionAtlas; Q7Z4T9; baseline and differential.
DR Genevisible; Q7Z4T9; HS.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:1904158; P:axonemal central apparatus assembly; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; IMP:UniProtKB.
DR InterPro; IPR026720; CFAP91.
DR InterPro; IPR032840; CFAP91_dom.
DR PANTHER; PTHR22455; PTHR22455; 1.
DR Pfam; PF14738; CFAP91; 1.
PE 1: Evidence at protein level;
KW Alternative promoter usage; Alternative splicing; Cell projection;
KW Cytoplasm; Cytoskeleton; Differentiation; Mitochondrion; Phosphoprotein;
KW Reference proteome; Spermatogenesis.
FT CHAIN 1..767
FT /note="Cilia- and flagella-associated protein 91"
FT /id="PRO_0000064417"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..736
FT /note="Missing (in isoform 5)"
FT /id="VSP_059499"
FT VAR_SEQ 1..126
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039503"
FT VAR_SEQ 1..67
FT /note="MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLYDPLFIVSSEKD
FT HTQANIQATLIRSRL -> MIFCT (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_014907"
FT VAR_SEQ 1..41
FT /note="MSHAVTIEEPQAQPQVSQTRYRERSRAGSHISSNRAYDFLY -> MIFCTVR
FT TAADLPLRPSPPRP (in isoform 8)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_039504"
FT VAR_SEQ 229..238
FT /note="RGLPAGQAEV -> ELVNLLTIGR (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_014910"
FT VAR_SEQ 239..767
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.2"
FT /id="VSP_014911"
FT VAR_SEQ 330..493
FT /note="Missing (in isoform 1)"
FT /id="VSP_059500"
FT VARIANT 207
FT /note="A -> P (in dbSNP:rs6438544)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.2"
FT /id="VAR_030243"
FT VARIANT 253
FT /note="S -> T (in dbSNP:rs9817771)"
FT /id="VAR_030244"
FT VARIANT 320
FT /note="S -> C (in dbSNP:rs9819218)"
FT /id="VAR_030245"
FT CONFLICT 311
FT /note="N -> D (in Ref. 3; BAG51535)"
FT /evidence="ECO:0000305"
FT CONFLICT 362
FT /note="K -> R (in Ref. 3; BAF82603)"
FT /evidence="ECO:0000305"
FT CONFLICT 508
FT /note="V -> I (in Ref. 2; AAP97317)"
FT /evidence="ECO:0000305"
FT CONFLICT 624
FT /note="R -> C (in Ref. 3; BAG51535)"
FT /evidence="ECO:0000305"
FT CONFLICT 636..637
FT /note="VK -> A (in Ref. 1; BAB60902)"
FT /evidence="ECO:0000305"
FT CONFLICT 649
FT /note="D -> A (in Ref. 4; CAH18098)"
FT /evidence="ECO:0000305"
FT CONFLICT 680
FT /note="E -> G (in Ref. 3; BAG63926)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 767 AA; 89955 MW; 7EBE6F798C496845 CRC64;
MSHAVTIEEP QAQPQVSQTR YRERSRAGSH ISSNRAYDFL YDPLFIVSSE KDHTQANIQA
TLIRSRLRKV PRFKTMFSNL IHYPRYSLYW SKSDPVPPFI SREWKGHKEK HREALRQLTT
TDASFQMPKE VYEDPEVTGK NRYKYFERPF LPFFQQMPFN VVYAVSKAEP YTFPPTSTKH
LSIPSKSTVG TQTDYRDADV QTDPYSAEYV VCQDSIPELL TLATLTWGRG LPAGQAEVEM
IERAREKRAW EASLPALSDT SQFEKRRKMM NEMERKEWAF REQEIEKLQE IRLEVLKELL
RKREENQNEV NMKHLNARWS KLQEGKEAKM AKIQRTHVST IRKLVGKRKN IEGKLERRNI
IKDYSDYASQ VYGPLSRLGC FPDNNSEDFV VKNYYLNTYE GLVELESCLP DFVTQPQIRA
PKPKVITTKA GFLKRAARLD YELAEVHKAL LDKKNKVLEV KKPPRFLQRN PIPQPRLPTP
TLEMTSNEEE EMEMAVIYLQ KLLRGRVVQN MMFEGKEKRL ELIQELRTCH ALQEDEKLVK
KAEKQVTLAL QRQRNLHEHK VSLVENHLAG LEGRALADMF DFLSKELVRL QEERRIHAFV
MLAERQRRVR EAEESGRRQV EKQRLREEDE IFKEVVKVHH STISSYLEDI ILNTEANTAE
EQARAEIEKM AEKINDIAYE MESRRTYLQS EEIVAELVYS FLIPEVQKYF VKEKVRNAQR
KHILAAHQII HSYTESMVQK KLTEGEQDEA SNAAMLLEKE TQNENNS
