CFA91_MACFA
ID CFA91_MACFA Reviewed; 767 AA.
AC Q95LR0; Q95JS7; Q95K36;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 3.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Cilia- and flagella-associated protein 91 {ECO:0000250|UniProtKB:Q7Z4T9};
DE Short=CFAP91 {ECO:0000305};
DE AltName: Full=AMY-1-associating protein expressed in testis 1;
DE Short=AAT-1;
DE AltName: Full=MYCBP/AMY-1-associated testis-expressed protein 1;
DE AltName: Full=Protein MAATS1;
GN Name=CFAP91; Synonyms=AAT1, MAATS1 {ECO:0000250|UniProtKB:Q7Z4T9};
GN ORFNames=QtsA-10510, QtsA-13847, QtsA-19865;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3).
RX PubMed=15863901; DOI=10.1248/bpb.28.898;
RA Matsuda E., Ishizaki R., Taira T., Iguchi-Ariga S.M.M., Ariga H.;
RT "Structure and characterization of AAT-1 isoforms.";
RL Biol. Pharm. Bull. 28:898-901(2005).
CC -!- FUNCTION: Involved in sperm flagellum axonemal organization and
CC function (By similarity). May regulate cilium motility through its role
CC in the assembly of the axonemal radial spokes (By similarity).
CC {ECO:0000250|UniProtKB:A8IH47, ECO:0000250|UniProtKB:Q7Z4T9}.
CC -!- SUBUNIT: Part of a complex containing MYCBP, AKAP1 and PRKAR2B.
CC {ECO:0000250|UniProtKB:Q7Z4T9}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q7Z4T9}.
CC Mitochondrion {ECO:0000250|UniProtKB:Q7Z4T9}. Cytoplasm, cytoskeleton,
CC cilium axoneme {ECO:0000250|UniProtKB:A8IH47}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=3; Synonyms=AAT-1L;
CC IsoId=Q95LR0-3; Sequence=Displayed;
CC Name=1; Synonyms=AAT-1M;
CC IsoId=Q95LR0-1; Sequence=VSP_059501;
CC Name=2; Synonyms=AAT-1S;
CC IsoId=Q95LR0-2; Sequence=VSP_014913;
CC -!- PTM: Phosphorylated by PKA. {ECO:0000250|UniProtKB:Q7Z4T9}.
CC -!- SIMILARITY: Belongs to the CFAP91 family.
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DR EMBL; AB069991; BAB62936.1; -; mRNA.
DR EMBL; AB070102; BAB63047.1; -; mRNA.
DR EMBL; AB071132; BAB64526.1; -; mRNA.
DR AlphaFoldDB; Q95LR0; -.
DR SMR; Q95LR0; -.
DR STRING; 9541.XP_005548113.1; -.
DR eggNOG; ENOG502QRFI; Eukaryota.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0031514; C:motile cilium; ISS:UniProtKB.
DR GO; GO:1904158; P:axonemal central apparatus assembly; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
DR InterPro; IPR026720; CFAP91.
DR InterPro; IPR032840; CFAP91_dom.
DR PANTHER; PTHR22455; PTHR22455; 1.
DR Pfam; PF14738; CFAP91; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell projection; Cytoplasm; Cytoskeleton;
KW Differentiation; Mitochondrion; Reference proteome; Spermatogenesis.
FT CHAIN 1..767
FT /note="Cilia- and flagella-associated protein 91"
FT /id="PRO_0000064418"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 81..595
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12498619"
FT /id="VSP_014913"
FT VAR_SEQ 330..493
FT /note="Missing (in isoform 1)"
FT /id="VSP_059501"
FT CONFLICT 78
FT /note="S -> N (in Ref. 1; BAB63047)"
FT /evidence="ECO:0000305"
FT CONFLICT 116..117
FT /note="RQ -> QL (in Ref. 1; BAB64526)"
FT /evidence="ECO:0000305"
FT CONFLICT 185
FT /note="S -> P (in Ref. 1; BAB62936)"
FT /evidence="ECO:0000305"
FT CONFLICT 611
FT /note="E -> K (in Ref. 1; BAB64526)"
FT /evidence="ECO:0000305"
FT CONFLICT 721
FT /note="K -> E (in Ref. 1; BAB62936)"
FT /evidence="ECO:0000305"
FT CONFLICT 759
FT /note="K -> E (in Ref. 1; BAB63047)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 767 AA; 90011 MW; 91F2C16866F2AA39 CRC64;
MSHAVTIQEP QAQPQVSQTR YRERSRAGSH ISSNRAYDFL YDPLFIVSSE KDHTQANIQA
TLIRSRLRKV PRFKTMFSNL IHYPRYSLYW SKSDPVPPFI SRQWKGHEEK HREALRQLAI
TDTSFQMPRE VYEDPEVTGK NRYKYFERPF LPFFQQMPFN VVYAISKAEP YTFPPTSTKQ
LSIPSKLTVG TQTDYRDADV QTDPYSPEYV VCQDSIPELL TLATLTWGRG LPAGQAEVEM
IERAREKRAW EATLPALSDT SQFEKRRKMM NEMERKEWAF REQEIEKLQE IRLEVLKELL
RKREENQNEV NMKHLNARWS KLQEAKEAKM ATIQRTHVST IRKLVGKGKN IEGKLERRNI
TKDYSDYASQ VYGPLSRLGC FPDNNSEDFV VKNYYLNTYE GLVELESRLP DFVTQPRIRA
PKPKVITTKA GFLKRAARLD YELAEVHKAL LDKKNKVLEA RKPPRFLQRN PIPQPRLPTP
TLEMTSNEEE EIEMAVIYLQ KLLRGRVIQN MMFEGKEKRL ELIQELRTCH ALQEDEKLVK
KAEKQVTLAL QRQRNLHEHK VSLVENHLAG LEGRALADMF DFLSKELVRL QEERRIHAFV
MLAERQRRIR EAEESGRRQV EKQRLREEDE IFKEVVKVHH STISSYLEDI ILNTEANTAE
EQARAEIEKM AEKINDIAYE MESRRTYLQS EEIVAELVYS FLIPEVQKYF VKEKVRNAQR
KHILAAHQII HSCTESMVQK RLTEGQQDEA SNAAMLLEKE IQNENNS
