CFA92_HUMAN
ID CFA92_HUMAN Reviewed; 409 AA.
AC Q9ULG3; Q8IXY7; Q8N5T4;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Uncharacterized protein CFAP92;
DE AltName: Full=Putative cilia and flagella associated protein 92 {ECO:0000312|HGNC:HGNC:29231};
GN Name=CFAP92 {ECO:0000312|HGNC:HGNC:29231}; Synonyms=KIAA1257;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=10574462; DOI=10.1093/dnares/6.5.337;
RA Nagase T., Ishikawa K., Kikuno R., Hirosawa M., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:337-345(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9ULG3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9ULG3-2; Sequence=VSP_031739;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH38736.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAA86571.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW79289.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB033083; BAA86571.1; ALT_INIT; mRNA.
DR EMBL; CH471052; EAW79289.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC031632; AAH31632.1; -; mRNA.
DR EMBL; BC038736; AAH38736.1; ALT_INIT; mRNA.
DR CCDS; CCDS46905.1; -. [Q9ULG3-1]
DR CCDS; CCDS87133.1; -. [Q9ULG3-2]
DR RefSeq; NP_001335451.1; NM_001348522.1. [Q9ULG3-2]
DR RefSeq; NP_001335452.1; NM_001348523.1. [Q9ULG3-2]
DR RefSeq; NP_065792.1; NM_020741.2. [Q9ULG3-1]
DR AlphaFoldDB; Q9ULG3; -.
DR BioGRID; 121566; 1.
DR IntAct; Q9ULG3; 1.
DR STRING; 9606.ENSP00000265068; -.
DR iPTMnet; Q9ULG3; -.
DR PhosphoSitePlus; Q9ULG3; -.
DR SwissPalm; Q9ULG3; -.
DR BioMuta; KIAA1257; -.
DR DMDM; 172044692; -.
DR EPD; Q9ULG3; -.
DR MassIVE; Q9ULG3; -.
DR PaxDb; Q9ULG3; -.
DR PeptideAtlas; Q9ULG3; -.
DR PRIDE; Q9ULG3; -.
DR Antibodypedia; 55543; 54 antibodies from 15 providers.
DR DNASU; 57501; -.
DR Ensembl; ENST00000265068.9; ENSP00000265068.5; ENSG00000114656.13. [Q9ULG3-1]
DR Ensembl; ENST00000515659.1; ENSP00000422539.1; ENSG00000114656.13. [Q9ULG3-2]
DR GeneID; 57501; -.
DR KEGG; hsa:57501; -.
DR UCSC; uc003eli.5; human. [Q9ULG3-1]
DR CTD; 57501; -.
DR DisGeNET; 57501; -.
DR GeneCards; CFAP92; -.
DR HGNC; HGNC:29231; CFAP92.
DR HPA; ENSG00000114656; Tissue enriched (testis).
DR MalaCards; CFAP92; -.
DR neXtProt; NX_Q9ULG3; -.
DR OpenTargets; ENSG00000114656; -.
DR PharmGKB; PA142671603; -.
DR VEuPathDB; HostDB:ENSG00000114656; -.
DR eggNOG; ENOG502S93N; Eukaryota.
DR GeneTree; ENSGT00390000008330; -.
DR InParanoid; Q9ULG3; -.
DR OrthoDB; 357663at2759; -.
DR PhylomeDB; Q9ULG3; -.
DR TreeFam; TF335973; -.
DR PathwayCommons; Q9ULG3; -.
DR SignaLink; Q9ULG3; -.
DR BioGRID-ORCS; 57501; 17 hits in 1078 CRISPR screens.
DR ChiTaRS; KIAA1257; human.
DR GenomeRNAi; 57501; -.
DR Pharos; Q9ULG3; Tdark.
DR PRO; PR:Q9ULG3; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; Q9ULG3; protein.
DR Bgee; ENSG00000114656; Expressed in left testis and 99 other tissues.
DR ExpressionAtlas; Q9ULG3; baseline and differential.
DR Genevisible; Q9ULG3; HS.
DR InterPro; IPR027876; DUF4550.
DR Pfam; PF15084; DUF4550; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..409
FT /note="Uncharacterized protein CFAP92"
FT /id="PRO_0000320679"
FT REGION 36..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..298
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 338..373
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..270
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..292
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..112
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_031739"
SQ SEQUENCE 409 AA; 46740 MW; 7B8A2DB2DD7F2B30 CRC64;
MSLHAWEWEE DPASIEPISS ITSFYQSTSE CDVEEHLKAK ARAQESDSDR PCSSIESSSE
PASTFSSDVP HVVPCKFTIS LAFPVNMGQK GKYASLIEKY KKHPKTDSSV TKMRRFYHIE
YFLLPDDEEP KKVDILLFPM VAKVFLESGV KTVKPWHEGD KAWVSWEQTF NITVTKELLK
KINFHKITLR LWNTKDKMSR KVRYYRLKTA GFTDDVGAFH KSEVRHLVLN QRKLSEQGIE
NTNIVREESN QEHPPGKQEK TEKHPKSLQG SHQAEPETSS KNSEEYEKSL KMDDSSTIQW
SVSRTPTISL AGASMMEIKE LIESESLSSL TNILDRQRSQ IKGKDSEGRR KIQRRHKKPL
AEEEADPTLT GPRKQSAFSI QLAVMPLLAG THCLPCSQQL LLVLWPERP
