ID   CFA99_HUMAN             Reviewed;         714 AA.
AC   D6REC4; A0A0U1RQC7;
DT   26-NOV-2014, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 2.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Cilia- and flagella-associated protein 99 {ECO:0000312|HGNC:HGNC:51180};
GN   Name=CFAP99 {ECO:0000312|HGNC:HGNC:51180};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000312|Proteomes:UP000005640};
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium, flagellum
CC       {ECO:0000250|UniProtKB:A8IUG5}.
CC   -!- SIMILARITY: Belongs to the CFAP99 family. {ECO:0000305}.
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DR   EMBL; AL645924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; KF459867; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_011511774.1; XM_011513472.2.
DR   AlphaFoldDB; D6REC4; -.
DR   SMR; D6REC4; -.
DR   BioMuta; CFAP99; -.
DR   EPD; D6REC4; -.
DR   MassIVE; D6REC4; -.
DR   PaxDb; D6REC4; -.
DR   PeptideAtlas; D6REC4; -.
DR   PRIDE; D6REC4; -.
DR   Ensembl; ENST00000635017.1; ENSP00000488922.1; ENSG00000206113.11.
DR   UCSC; uc062upn.1; human.
DR   GeneCards; CFAP99; -.
DR   HGNC; HGNC:51180; CFAP99.
DR   neXtProt; NX_D6REC4; -.
DR   OpenTargets; ENSG00000206113; -.
DR   VEuPathDB; HostDB:ENSG00000206113; -.
DR   eggNOG; ENOG502QTX0; Eukaryota.
DR   GeneTree; ENSGT00500000045231; -.
DR   HOGENOM; CLU_595740_0_0_1; -.
DR   InParanoid; D6REC4; -.
DR   OMA; QLDKFKP; -.
DR   PhylomeDB; D6REC4; -.
DR   BioGRID-ORCS; 402160; 9 hits in 181 CRISPR screens.
DR   ChiTaRS; CFAP99; human.
DR   GenomeRNAi; 402160; -.
DR   Pharos; D6REC4; Tdark.
DR   PRO; PR:D6REC4; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; D6REC4; protein.
DR   Bgee; ENSG00000206113; Expressed in right uterine tube and 92 other tissues.
DR   GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR   InterPro; IPR039341; CFAP99.
DR   PANTHER; PTHR34649; PTHR34649; 1.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Coiled coil; Flagellum; Reference proteome.
FT   CHAIN           1..714
FT                   /note="Cilia- and flagella-associated protein 99"
FT                   /id="PRO_0000430951"
FT   REGION          195..227
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          695..714
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          368..459
FT                   /evidence="ECO:0000255"
FT   COILED          494..522
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        198..219
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   714 AA;  81886 MW;  AF21E75C0724BEB0 CRC64;
     MAYYGKCIET VIEQLDKFTP KRDNPEQFLE AAATSLQALS PQKQSFVLEV LSGCLEYRKL
     LTVVVDAFYV EDGRLCLRVD HSRFEVICYL ATFLLEELGF QLFCNIIKSQ PVDKMCKFLR
     FFFNPLHLCS WIKDEWSLIY EPAHVKENWI DPLMRWQPEV QELINHLEGV SASQSSPLKT
     KAKVTEPKEF NLTAPRPRTI PAPEPVPVVA KPRPVPQSTY QPPKEQQQLE TVKRYNRRKA
     EELLLRANIE ELRCAMPRSC RERVQGSKQQ LRLQFPPRIR KTPKLTFYRP DNILVKLNTT
     AILREGALYQ RQVEQELQRV DKLVDGAGDF SEFFEWQKKM QAKDREEQLA ASECRRLQGK
     LSHEEAVLAR QSLMQENKQR VEQQKEQMAK LMLQRAERRL REDRSRKELV EQVIEGQKNA
     KAAQTKLAKG RQQTVQEAIE ESRGLLQRRA QAAQEEQRRR CELISQLRAL ETQPTRKGKL
     VDLTQIPGYG LEGEMSIVEL RERLALLKEN QRRKEEEKRD QIIQGKHTKS QELQNMVEQI
     SLCRAAMGRS AALRWEEKKA LAAAPAAPSQ DERVQQLRRR ISERAAERSR QAALLHVSAP
     RTARPKPRVS PDWWEEPGRL KAGAGWGWRA RRAGTGVPGR GWRGDRVRSA AGRYAAAGAG
     GGGGVPARAD AFPGLQAQLE AQHWLELERS RERRLQALQQ GGSGPGPARR LEAA