ID   CFAC_ECOLX              Reviewed;         869 AA.
AC   P25733;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1992, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=CFA/I fimbrial subunit C;
DE   AltName: Full=Colonization factor antigen I subunit C;
DE   Flags: Precursor;
GN   Name=cfaC;
OS   Escherichia coli.
OG   Plasmid NTP513.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=562;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ETEC;
RX   PubMed=2569152; DOI=10.1016/0882-4010(89)90103-4;
RA   Hamers A.M., Pel H.J., Willshaw G.A., Kusters J.G., van der Zeijst B.A.M.,
RA   Gaastra W.;
RT   "The nucleotide sequence of the first two genes of the CFA/I fimbrial
RT   operon of human enterotoxigenic Escherichia coli.";
RL   Microb. Pathog. 6:297-309(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1352712; DOI=10.3109/10425179209020811;
RA   Jordi B.J.A.M., Willshaw G.A., van der Zeijst B.A.M., Gaastra W.;
RT   "The complete nucleotide sequence of region 1 of the CFA/I fimbrial operon
RT   of human enterotoxigenic Escherichia coli.";
RL   DNA Seq. 2:257-263(1992).
CC   -!- FUNCTION: May serve as anchor for the fimbriae in the outer membrane.
CC   -!- SUBCELLULAR LOCATION: Fimbrium {ECO:0000305}. Cell outer membrane
CC       {ECO:0000305}.
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DR   EMBL; M55661; AAC41416.1; -; Genomic_DNA.
DR   PIR; C56617; C56617.
DR   AlphaFoldDB; P25733; -.
DR   TCDB; 1.B.11.4.1; the outer membrane fimbrial usher porin (fup) family.
DR   GO; GO:0009279; C:cell outer membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0009289; C:pilus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR031917; Pilus_assem_C.
DR   InterPro; IPR032636; Pilus_assem_E-set-like_dom.
DR   InterPro; IPR035224; Usher_TcfC.
DR   Pfam; PF15976; CooC_C; 1.
DR   Pfam; PF16967; TcfC; 1.
DR   Pfam; PF17271; Usher_TcfC; 1.
PE   3: Inferred from homology;
KW   Cell outer membrane; Fimbrium; Membrane; Plasmid; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..869
FT                   /note="CFA/I fimbrial subunit C"
FT                   /id="PRO_0000009248"
SQ   SEQUENCE   869 AA;  97831 MW;  EC4C626DA9B718B7 CRC64;
     MKHKKKNRLV VAISVALIPY IGVTGDIPDS FRDLWGEQDE FYEVKLYGQT LGIHRIKTTP
     THIKFYSPES ILDKINLKKE KEKELSVFFT NSFSRNGNMS CQGNTTIQYN CNYIKTKSVD
     VIVDDVDNVV NLFIGNEFLD SEAHNDEYHQ LSRNVKKAFI QSQTINLSDS GKYKRLSISG
     NSALGITDTS YAVLNWWMNY NKSNGYSNNE KTINSLYFRH DLDKRYYYQF GRMDRTDLSQ
     SISGSFNFNL LPLPDIDGIR TGTTQSYIKN TDKFIASPVT VMLTNFSRVE AFRNDQLLGV
     WYLDSGVNEL DTARLPYGSY DLKLKIFENT QLVREEIIPF NKGRSSIGDM QWDIFVQGGN
     IVNDNDRYIE KQNNHKSSIN TGLRLPITKN ISVQQGVSVI DNKSYYEGSL KWNSGILSGS
     LNSEFSFLWG DNAKGNYQSI SYTDGFSLSF YHNDKRVDNC GRNYNAGWSG CYESYSASLS
     IPLLGWTSTL GYSDTYSESV YKSHILSEYG FYNQNIYKGR TQRWQLTSST SLKWMDYNFM
     PAIGIYNSEQ RQLTDKGGYI SVTITRASRE NSLNTGYSYN YSRGNYSSNE LFVDGYMTST
     NNGDYHEAGM RFNKNRHNAE GRLSGRINNR FGDLNGSFSM NKNRNTNSTN HSLTGGYNSS
     FALTSDGFYW GGSTAGLTKL AGGIIKVKSN DTKKNLVKVT GTLYGDYSLG SNDNAFIPVP
     ALTPASLIIE DNNYGDNNIS ILAPTNNDMF MLPGNVYPVE IETKVSVSYI GRGFDPNGTP
     LSGAHVLNEP HVILDEDGGF SFEYTGNEKT LFLLKGRTIY TCQLGKNKVH KGIVFVGDVI
     CDINSTSSLP DEFVKNPRVQ DLLAKNDKG