ID   CFBE_METAC              Reviewed;         472 AA.
AC   Q8TJZ6;
DT   22-NOV-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   03-AUG-2022, entry version 84.
DE   RecName: Full=Coenzyme F(430) synthetase {ECO:0000303|PubMed:27846569};
DE            EC=6.4.1.9 {ECO:0000269|PubMed:27846569};
GN   Name=cfbE {ECO:0000303|PubMed:27846569};
GN   Synonyms=murD {ECO:0000312|EMBL:AAM06985.1};
GN   OrderedLocusNames=MA_3630 {ECO:0000312|EMBL:AAM06985.1};
OS   Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 /
OS   C2A).
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=188937;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A
RC   {ECO:0000312|Proteomes:UP000002487};
RX   PubMed=11932238; DOI=10.1101/gr.223902;
RA   Galagan J.E., Nusbaum C., Roy A., Endrizzi M.G., Macdonald P., FitzHugh W.,
RA   Calvo S., Engels R., Smirnov S., Atnoor D., Brown A., Allen N., Naylor J.,
RA   Stange-Thomann N., DeArellano K., Johnson R., Linton L., McEwan P.,
RA   McKernan K., Talamas J., Tirrell A., Ye W., Zimmer A., Barber R.D.,
RA   Cann I., Graham D.E., Grahame D.A., Guss A.M., Hedderich R.,
RA   Ingram-Smith C., Kuettner H.C., Krzycki J.A., Leigh J.A., Li W., Liu J.,
RA   Mukhopadhyay B., Reeve J.N., Smith K., Springer T.A., Umayam L.A.,
RA   White O., White R.H., de Macario E.C., Ferry J.G., Jarrell K.F., Jing H.,
RA   Macario A.J.L., Paulsen I.T., Pritchett M., Sowers K.R., Swanson R.V.,
RA   Zinder S.H., Lander E., Metcalf W.W., Birren B.;
RT   "The genome of Methanosarcina acetivorans reveals extensive metabolic and
RT   physiological diversity.";
RL   Genome Res. 12:532-542(2002).
RN   [2]
RP   FUNCTION, AND CATALYTIC ACTIVITY.
RC   STRAIN=ATCC 35395 / DSM 2834 / JCM 12185 / C2A;
RX   PubMed=27846569; DOI=10.1126/science.aag2947;
RA   Zheng K., Ngo P.D., Owens V.L., Yang X.P., Mansoorabadi S.O.;
RT   "The biosynthetic pathway of coenzyme F430 in methanogenic and
RT   methanotrophic archaea.";
RL   Science 354:339-342(2016).
CC   -!- FUNCTION: Involved in the biosynthesis of the unique nickel-containing
CC       tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M
CC       reductase (MCR), which plays a key role in methanogenesis and anaerobic
CC       methane oxidation. Catalyzes the activation the g-propionate side chain
CC       of 15,17(3)-seco-F430-17(3)-acid (seco-F430) for intramolecular C-C
CC       bond formation to yield the carbocyclic F ring of coenzyme F430.
CC       {ECO:0000269|PubMed:27846569}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=15,17(3)-seco-F430-17(3)-acid + ATP = ADP + coenzyme F430 +
CC         phosphate; Xref=Rhea:RHEA:52904, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:60540, ChEBI:CHEBI:136888,
CC         ChEBI:CHEBI:456216; EC=6.4.1.9;
CC         Evidence={ECO:0000269|PubMed:27846569};
CC   -!- SIMILARITY: Belongs to the MurCDEF family. {ECO:0000305}.
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DR   EMBL; AE010299; AAM06985.1; -; Genomic_DNA.
DR   RefSeq; WP_011023538.1; NC_003552.1.
DR   AlphaFoldDB; Q8TJZ6; -.
DR   SMR; Q8TJZ6; -.
DR   STRING; 188937.MA_3630; -.
DR   EnsemblBacteria; AAM06985; AAM06985; MA_3630.
DR   GeneID; 1475523; -.
DR   KEGG; mac:MA_3630; -.
DR   HOGENOM; CLU_047362_0_0_2; -.
DR   InParanoid; Q8TJZ6; -.
DR   OMA; VIAPVHC; -.
DR   OrthoDB; 50390at2157; -.
DR   BioCyc; MetaCyc:MON-20117; -.
DR   Proteomes; UP000002487; Chromosome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1190.10; -; 1.
DR   InterPro; IPR036565; Mur-like_cat_sf.
DR   SUPFAM; SSF53623; SSF53623; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Ligase; Methanogenesis; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..472
FT                   /note="Coenzyme F(430) synthetase"
FT                   /id="PRO_0000442422"
FT   BINDING         119..125
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   472 AA;  50407 MW;  C57D750B2CCA0CE4 CRC64;
     MDLFRKKLAV LDLTHGGIPI ARKLAALGND VSGVDVYGTV DQALLGELEE KYGIRCSKAP
     LPVSDFDLLI APVHLDPAYP MLIKARSEGK TVLSHHEAVG KILQADPRLS EIKIVEITGV
     KAKTSTASLL ADMLSRSFKV VLHTSRGLEA WKAGIPFLIH RGLSITPGSI LIAVEKSLEQ
     EIRPEFFIFE ISIGATGTAD LGILTTLSPD YGIANNTSLA SDAKLQLVLN ARPGSTLLLN
     AGAEKALEAA KGSLAKVLTF KDPFCSDSYL KLADAPDFVL ETESGAEKNL TLHFLRRGEE
     LFSASLCPGY NSSAYRTAFV AASAAALELG VGLEAIVSVL EEFRGLSGRM QEKELNGVVL
     VDNSNSGMDI LSAEKALEYA LLKKKDEKKG NIILILGEEA SQVCEGLPPG SVQGFLEKFG
     TKCRHIILVG ERMEAVAAEN ASYAGSLPEG LQKASELAGT EDIILSSVKC FR