ID   CFC1B_HUMAN             Reviewed;         223 AA.
AC   P0CG36; B2RCY0; B9EJD3; Q53T05; Q9GZR3;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Cryptic family protein 1B;
DE   Flags: Precursor;
GN   Name=CFC1B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.
CC       {ECO:0000305}.
CC   -!- CAUTION: This gene differs from CFC1 by only one residue at position
CC       78:R -> W. R78W is also thought to be a CFC1 polymorphism.
CC       {ECO:0000305}.
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DR   EMBL; AC013269; AAY14955.1; -; Genomic_DNA.
DR   CCDS; CCDS33286.1; -.
DR   RefSeq; NP_001072998.1; NM_001079530.1.
DR   AlphaFoldDB; P0CG36; -.
DR   STRING; 9606.ENSP00000281882; -.
DR   GlyGen; P0CG36; 1 site.
DR   BioMuta; CFC1B; -.
DR   DMDM; 300680885; -.
DR   MassIVE; P0CG36; -.
DR   PaxDb; P0CG36; -.
DR   PeptideAtlas; P0CG36; -.
DR   PRIDE; P0CG36; -.
DR   ABCD; P0CG36; 8 sequenced antibodies.
DR   Antibodypedia; 68636; 51 antibodies from 15 providers.
DR   DNASU; 653275; -.
DR   Ensembl; ENST00000281882.8; ENSP00000281882.3; ENSG00000152093.8.
DR   GeneID; 653275; -.
DR   KEGG; hsa:653275; -.
DR   MANE-Select; ENST00000281882.8; ENSP00000281882.3; NM_001079530.2; NP_001072998.1.
DR   UCSC; uc002trl.3; human.
DR   CTD; 653275; -.
DR   DisGeNET; 653275; -.
DR   GeneCards; CFC1B; -.
DR   HGNC; HGNC:33983; CFC1B.
DR   HPA; ENSG00000152093; Tissue enhanced (pituitary).
DR   neXtProt; NX_P0CG36; -.
DR   OpenTargets; ENSG00000152093; -.
DR   PharmGKB; PA162382207; -.
DR   VEuPathDB; HostDB:ENSG00000152093; -.
DR   eggNOG; KOG1217; Eukaryota.
DR   GeneTree; ENSGT00940000162302; -.
DR   HOGENOM; CLU_092661_0_0_1; -.
DR   InParanoid; P0CG36; -.
DR   OMA; GNASCEG; -.
DR   OrthoDB; 1387592at2759; -.
DR   PhylomeDB; P0CG36; -.
DR   TreeFam; TF333187; -.
DR   PathwayCommons; P0CG36; -.
DR   BioGRID-ORCS; 653275; 20 hits in 976 CRISPR screens.
DR   GeneWiki; Cripto; -.
DR   GenomeRNAi; 653275; -.
DR   Pharos; P0CG36; Tdark.
DR   PRO; PR:P0CG36; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; P0CG36; protein.
DR   Bgee; ENSG00000152093; Expressed in islet of Langerhans and 38 other tissues.
DR   ExpressionAtlas; P0CG36; baseline and differential.
DR   Genevisible; P0CG36; HS.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR   GO; GO:0070697; F:activin receptor binding; IBA:GO_Central.
DR   GO; GO:0038100; F:nodal binding; IBA:GO_Central.
DR   GO; GO:0005102; F:signaling receptor binding; IBA:GO_Central.
DR   GO; GO:0048856; P:anatomical structure development; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0001568; P:blood vessel development; IBA:GO_Central.
DR   GO; GO:0007368; P:determination of left/right symmetry; IBA:GO_Central.
DR   GO; GO:0007369; P:gastrulation; IEA:UniProtKB-KW.
DR   GO; GO:0007507; P:heart development; IBA:GO_Central.
DR   GO; GO:0038092; P:nodal signaling pathway; IBA:GO_Central.
DR   InterPro; IPR019011; Cryptic/Cripto_CFC-dom.
DR   InterPro; IPR000742; EGF-like_dom.
DR   Pfam; PF09443; CFC; 1.
DR   PROSITE; PS00022; EGF_1; 1.
DR   PROSITE; PS50026; EGF_3; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Disulfide bond; EGF-like domain; Gastrulation;
KW   Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..223
FT                   /note="Cryptic family protein 1B"
FT                   /id="PRO_0000395408"
FT   DOMAIN          86..115
FT                   /note="EGF-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   CARBOHYD        52
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        90..97
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        91..103
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
FT   DISULFID        105..114
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00076"
SQ   SEQUENCE   223 AA;  24642 MW;  457EB443BC0CF1A5 CRC64;
     MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE
     VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR
     SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCDPK DFLASHAHGP SAGGAPSLLL
     LLPCALLHRL LRPDAPAHPR SLVPSVLQRE RRPCGRPGLG HRL