ID   ACDE1_METTE             Reviewed;         170 AA.
AC   P72020;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit epsilon 1 {ECO:0000255|HAMAP-Rule:MF_01134};
DE            Short=ACDS complex subunit epsilon 1 {ECO:0000255|HAMAP-Rule:MF_01134};
DE   AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit epsilon 1 {ECO:0000255|HAMAP-Rule:MF_01134};
DE            Short=ACDS CODH subunit epsilon 1 {ECO:0000255|HAMAP-Rule:MF_01134};
GN   Name=cdhB1;
OS   Methanosarcina thermophila.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-16.
RC   STRAIN=ATCC 43570 / DSM 1825 / OCM 12 / TM-1;
RX   PubMed=8955306; DOI=10.1128/jb.178.23.6849-6856.1996;
RA   Maupin-Furlow J.A., Ferry J.G.;
RT   "Analysis of the CO dehydrogenase/acetyl-Coenzyme A synthase operon of
RT   Methanosarcina thermophila.";
RL   J. Bacteriol. 178:6849-6856(1996).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC       acetyl-CoA, allowing growth on acetate as sole source of carbon and
CC       energy. The alpha-epsilon subcomponent functions as a carbon monoxide
CC       dehydrogenase. The precise role of the epsilon subunit is unclear; it
CC       may have a stabilizing role within the alpha(2)epsilon(2) component
CC       and/or be involved in electron transfer to FAD during a potential FAD-
CC       mediated CO oxidation. {ECO:0000255|HAMAP-Rule:MF_01134}.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
CC       {ECO:0000255|HAMAP-Rule:MF_01134}.
CC   -!- SUBUNIT: Heterotetramer of two alpha and two epsilon subunits. The ACDS
CC       complex is made up of alpha, epsilon, beta, gamma and delta subunits
CC       with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-
CC       (gamma(1)delta(1))(8). {ECO:0000255|HAMAP-Rule:MF_01134}.
CC   -!- SIMILARITY: Belongs to the CdhB family. {ECO:0000255|HAMAP-
CC       Rule:MF_01134}.
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DR   EMBL; U66032; AAC44651.1; -; Genomic_DNA.
DR   AlphaFoldDB; P72020; -.
DR   SMR; P72020; -.
DR   KEGG; ag:AAC44651; -.
DR   BioCyc; MetaCyc:CDHBMSARC-MON; -.
DR   UniPathway; UPA00642; -.
DR   GO; GO:0018492; F:carbon-monoxide dehydrogenase (acceptor) activity; IDA:MENGO.
DR   GO; GO:0019385; P:methanogenesis, from acetate; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_01134; CdhB; 1.
DR   InterPro; IPR003704; CO_DH_CoA_synth.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   Pfam; PF02552; CO_dh; 1.
DR   PIRSF; PIRSF006035; CO_dh_b_ACDS_e; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
DR   TIGRFAMs; TIGR00315; cdhB; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Methanogenesis.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8955306"
FT   CHAIN           2..170
FT                   /note="Acetyl-CoA decarbonylase/synthase complex subunit
FT                   epsilon 1"
FT                   /id="PRO_0000155095"
SQ   SEQUENCE   170 AA;  18740 MW;  5534CA08ACF51663 CRC64;
     MVDTTKNTKL FTSYGVTTSK AINPDMAAKM ISKAKRPLFV VGTGVLRPEI LDRAVKIAKK
     ANLPIAATGS SLNGFLDKDV DAKYINVHQL GFYLTDPAWP GLDGKGNYDT IIILEFKKYY
     INQVLSGTKN FSKVKSISIG KDYIQNATMS FGNISREEHF AALDELIDLL