CFDP2_BOVIN
ID CFDP2_BOVIN Reviewed; 592 AA.
AC O02751; O02752; O18732; Q7JFY0; Q8I032;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 22-NOV-2005, sequence version 2.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Craniofacial development protein 2;
DE AltName: Full=p97 bucentaur protein;
GN Name=CFDP2; Synonyms=BCNT;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 8-15; 35-45; 64-74; 98-114;
RP 133-144; 148-152; 241-247; 489-491 AND 493-500, AND TISSUE SPECIFICITY.
RC TISSUE=Brain;
RX PubMed=9006920; DOI=10.1074/jbc.272.5.2801;
RA Nobukuni T., Kobayashi M., Omori A., Ichinose S., Iwanaga T., Takahashi I.,
RA Hashimoto K., Hattori S., Kaibuchi K., Miyata Y., Masui T., Iwashita S.;
RT "An Alu-linked repetitive sequence corresponding to 280 amino acids is
RT expressed in a novel bovine protein, but not in its human homologue.";
RL J. Biol. Chem. 272:2801-2807(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND GENE
RP DUPLICATION.
RC STRAIN=Jersey;
RX PubMed=12832649; DOI=10.1093/molbev/msg168;
RA Iwashita S., Osada N., Itoh T., Sezaki M., Oshima K., Hashimoto E.,
RA Kitagawa-Arita Y., Takahashi I., Masui T., Hashimoto K., Makalowski W.;
RT "A transposable element-mediated gene divergence that directly produces a
RT novel type bovine Bcnt protein including the endonuclease domain of RTE-
RT 1.";
RL Mol. Biol. Evol. 20:1556-1563(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 132-522, AND GENE DUPLICATION.
RX PubMed=9602175; DOI=10.1016/s0378-1119(98)00136-x;
RA Takahashi I., Nobukuni T., Ohmori H., Kobayashi M., Tanaka S., Ohshima K.,
RA Okada N., Masui T., Hashimoto K., Iwashita S.;
RT "Existence of a bovine LINE repetitive insert that appears in the cDNA of
RT bovine protein BCNT in ruminant, but not in human, genomes.";
RL Gene 211:387-394(1998).
RN [4]
RP PHOSPHORYLATION, AND SUBCELLULAR LOCATION.
RX PubMed=10350657; DOI=10.1016/s0304-4165(99)00049-5;
RA Iwashita S., Nobukuni T., Tanaka S., Kobayashi M., Iwanaga T., Tamate H.B.,
RA Masui T., Takahashi I., Hashimoto K.;
RT "Partial nuclear localization of a bovine phosphoprotein, BCNT, that
RT includes a region derived from a LINE repetitive sequence in Ruminantia.";
RL Biochim. Biophys. Acta 1427:408-416(1999).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:10350657}. Nucleus
CC {ECO:0000269|PubMed:10350657}.
CC -!- TISSUE SPECIFICITY: Expressed in liver and lung with higher expression
CC in brain. {ECO:0000269|PubMed:12832649, ECO:0000269|PubMed:9006920}.
CC -!- PTM: Phosphorylated by CK2 (casein kinase II) in vitro.
CC {ECO:0000269|PubMed:10350657}.
CC -!- MISCELLANEOUS: Gene duplication of the ancestral BCNT gene leads to the
CC h-type BCNT (CFDP1) gene and the p97BCNT (CFDP2) gene. The latter
CC contains a region derived from the endonuclease domain of a
CC retrotransposable element RTE-1. This repetitive sequence associated
CC with the BCNT gene is specific to Ruminantia.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; D84513; BAA20065.1; -; mRNA.
DR EMBL; D84514; BAA20066.1; -; mRNA.
DR EMBL; D84515; BAA20067.1; -; mRNA.
DR EMBL; AB081095; BAC15592.1; -; Genomic_DNA.
DR EMBL; AB005652; BAA21722.1; -; Genomic_DNA.
DR RefSeq; NP_777225.1; NM_174800.2.
DR AlphaFoldDB; O02751; -.
DR SMR; O02751; -.
DR STRING; 9913.ENSBTAP00000012929; -.
DR iPTMnet; O02751; -.
DR PaxDb; O02751; -.
DR PeptideAtlas; O02751; -.
DR PRIDE; O02751; -.
DR GeneID; 286876; -.
DR KEGG; bta:286876; -.
DR CTD; 286876; -.
DR eggNOG; KOG1075; Eukaryota.
DR eggNOG; KOG4776; Eukaryota.
DR InParanoid; O02751; -.
DR OrthoDB; 777540at2759; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0006338; P:chromatin remodeling; IBA:GO_Central.
DR Gene3D; 3.60.10.10; -; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR InterPro; IPR027124; Swc5/CFDP1/2.
DR PANTHER; PTHR23227; PTHR23227; 1.
DR Pfam; PF03372; Exo_endo_phos; 1.
DR SUPFAM; SSF56219; SSF56219; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Direct protein sequencing; Nucleus; Reference proteome.
FT CHAIN 1..592
FT /note="Craniofacial development protein 2"
FT /id="PRO_0000212492"
FT REGION 1..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..592
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 499..578
FT /note="Hydrophilic"
FT COMPBIAS 1..31
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..141
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..166
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 184..210
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 499..522
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 523..550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 57
FT /note="I -> V (in Ref. 2; BAC15592)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="I -> V (in Ref. 2; BAC15592)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="Q -> K (in Ref. 2; BAC15592)"
FT /evidence="ECO:0000305"
FT CONFLICT 133
FT /note="T -> K (in Ref. 3; BAA21722)"
FT /evidence="ECO:0000305"
FT CONFLICT 187
FT /note="E -> K (in Ref. 1; BAA20065)"
FT /evidence="ECO:0000305"
FT CONFLICT 195..196
FT /note="GV -> VF (in Ref. 1; BAA20066)"
FT /evidence="ECO:0000305"
FT CONFLICT 219
FT /note="Q -> P (in Ref. 2; BAC15592)"
FT /evidence="ECO:0000305"
FT CONFLICT 545..550
FT /note="ETSQEA -> GRGSRN (in Ref. 1; BAA20066)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 592 AA; 66325 MW; 267211E164B931E0 CRC64;
MEEFDSKDIS TSKDEDCVPL GGECHEDDIN ELVKEDEVDG EEETQKTKGT KRKAESILAR
KRKQGRLSLD QEEEEDASRE SGGRIIEKED AAAEQEKGAE SEDARQEEAD VLASSVSDAE
PKSELPPSTQ TKTGEETEET SSSNLVKVEE LEKPKKAEEV KLTKSPLAGE EVRFLTQQGR
LSGRTSEDEP RRSEGVQHAT GEERRADTNT SSKNEAAGQK WKGQSAVDVS GDESKLRCCK
EEYCIGTWNV RSMNPGKLDV VKQEMERINI DILGISELKW TGMGELNSDD HYIYYCGQQS
LRRNGVALIV NKRVRNAIIG CNLKNDRMIS VRFQGKPFNL TVIQVYAPTP YAEEGEVYRF
YEDLQHLLEI TPKIDVLFII GDWNAKVGSQ EIPGITGRFG LGMQNEAGRR LIEFCHHNRL
VITNTLFQQP SRRLYTWTSP DGRYRDQIDY IICRQRWRSS VQSAKTRPGA DCGSDHKLLI
AKFRLKLKII PKTTRPFRVT NEEDATNEEA KSVLKQNEKE KPEANVPSTV SSVPGGSGMT
KEVGETSQEA KSVFKQDEKD KPQANVPSSV PSLPAGSGPE KCDLEKKKDC NN
