ID   CFDP2_TRAJA             Reviewed;         574 AA.
AC   Q588U8; Q60FC8; Q75S81;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=Craniofacial development protein 2;
DE   AltName: Full=p97 bucentaur protein;
GN   Name=CFDP2; Synonyms=BCNT;
OS   Tragulus javanicus (Lesser Malay chevrotain) (Lesser mouse deer).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Tragulina; Tragulidae;
OC   Tragulus.
OX   NCBI_TaxID=9849;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RA   Ueno S., Kimura J., Kurohmaru M., Fukuta K., Iwashita S.;
RT   "Gene organization of the chevrotain bcnt whose paralogue in ruminantia
RT   includes an endonuclease domain of RTE-1 in the protein.";
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Muscle;
RA   Ueno S., Nakashima K., Osada N., Kubo Y., Ohshima K., Tanaka K., Endo H.,
RA   Kimura J., Kurohmaru M., Fukuta K., David L., Iwashita S.;
RT   "The diversification of the paralogous Bcnt gene in ruminants was
RT   accompanied by the recruitment of an endonuclease domain from a
RT   retrotransposable element-1.";
RL   Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- MISCELLANEOUS: Gene duplication of the ancestral BCNT gene leads to the
CC       h-type BCNT (CFDP1) gene and the p97BCNT (CFDP2) gene. The latter
CC       contains a region derived from the endonuclease domain of a
CC       retrotransposable element RTE-1. This repetitive sequence associated
CC       with the BCNT gene is specific to Ruminantia.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB191483; BAD52447.1; -; Genomic_DNA.
DR   EMBL; AB192410; BAD93708.1; -; Genomic_DNA.
DR   EMBL; AB158226; BAD06249.1; -; mRNA.
DR   AlphaFoldDB; Q588U8; -.
DR   SMR; Q588U8; -.
DR   PRIDE; Q588U8; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   Gene3D; 3.60.10.10; -; 1.
DR   InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR   InterPro; IPR005135; Endo/exonuclease/phosphatase.
DR   InterPro; IPR027124; Swc5/CFDP1/2.
DR   PANTHER; PTHR23227; PTHR23227; 1.
DR   Pfam; PF03372; Exo_endo_phos; 1.
DR   SUPFAM; SSF56219; SSF56219; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus.
FT   CHAIN           1..574
FT                   /note="Craniofacial development protein 2"
FT                   /id="PRO_0000212499"
FT   REGION          1..222
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          488..574
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          493..572
FT                   /note="Hydrophilic"
FT   COMPBIAS        41..115
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        135..171
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        193..209
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        492..512
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        513..546
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        137
FT                   /note="E -> K (in Ref. 1; BAD06249)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   574 AA;  63428 MW;  BD532AC80A138970 CRC64;
     MEEVDSKDIS SSKAEDCVPS GGECHEEAVD ELMKEDEVGG EEETEQTKGI KRKAESILPR
     KNKQGRLSLE QEDEEDANKE SGGGGSEKED AATEQEKGVE SEDARKKKED EVLASSVNDA
     EPESKVPPST PAKTGEETEE TRSGEEQEKP KEMQEVKLTK SLVEEVRCDR QQGRSSGMTP
     EDEPPRSESS PCAPGQVKKT GTNASSKNEP AGAKWKGQPA VDASSDESKL RCCKEEYCIG
     TWNVRSMNPG KLDVVKQEMD RINIDILGIS ELKWTGMGEL NSDDHYIYYC GQQSLRRNGV
     ALIVNKRVQN AIIGCNLKND RMISLRFQGK PFNLTVIQVF APTPYAEEGE VYRFYEDLQH
     LLEITPKIDV LFIIGDWNAK VGSQEIPGIT GRFGLGMQNE AGRRLIDFCH HNRLVIANTL
     FQQPSRRLYT WTSPDGRFRD QIDYIICRQR WRSSVQSAKT RPGADCGSDH KLLIAKFRLK
     LKIIPKTTRP FRGTNEADDT SEESKPSSEQ KGKEKPQASV PSAVSSVPGG SGVTKEVGAT
     SQEAKSVVKQ NEKEEPQANV LSAVPSLPAG SGVF