CFI1_FRAAN
ID CFI1_FRAAN Reviewed; 237 AA.
AC Q4AE11;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Chalcone--flavanone isomerase 1;
DE Short=Chalcone isomerase 1;
DE EC=5.5.1.6;
GN Name=CHI1; Synonyms=FrCHI23;
OS Fragaria ananassa (Strawberry) (Fragaria chiloensis x Fragaria virginiana).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; fabids; Rosales; Rosaceae; Rosoideae; Potentilleae; Fragariinae;
OC Fragaria.
OX NCBI_TaxID=3747;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Sachinoka; TISSUE=Fruit cortical tissue;
RA Adachi Y., Chiba N., Suzuki G., Kano H., Nakamura S.;
RT "Genes regulating anthocyanin-synthesis pathway in white wild strawberry.";
RL Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Catalyzes the intramolecular cyclization of bicyclic
CC chalcones into tricyclic (S)-flavanones. Responsible for the
CC isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone)
CC into naringenin (By similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a chalcone = a flavanone.; EC=5.5.1.6;
CC -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC -!- MISCELLANEOUS: Part of the biosynthetic pathway for all classes of
CC flavonoids, a large class of secondary plant metabolites, many of which
CC are brightly colored.
CC -!- SIMILARITY: Belongs to the chalcone isomerase family. {ECO:0000305}.
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DR EMBL; AB201755; BAE17121.1; -; mRNA.
DR AlphaFoldDB; Q4AE11; -.
DR SMR; Q4AE11; -.
DR UniPathway; UPA00154; -.
DR GO; GO:0045430; F:chalcone isomerase activity; IEA:UniProtKB-EC.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.890.20; -; 1.
DR Gene3D; 3.50.70.10; -; 1.
DR InterPro; IPR044164; CFI.
DR InterPro; IPR016087; Chalcone_isomerase.
DR InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR InterPro; IPR016089; Chalcone_isomerase_bundle_sf.
DR InterPro; IPR036298; Chalcone_isomerase_sf.
DR PANTHER; PTHR28039; PTHR28039; 1.
DR Pfam; PF02431; Chalcone; 1.
DR SUPFAM; SSF54626; SSF54626; 1.
PE 2: Evidence at transcript level;
KW Flavonoid biosynthesis; Isomerase.
FT CHAIN 1..237
FT /note="Chalcone--flavanone isomerase 1"
FT /id="PRO_0000300836"
FT BINDING 48
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 113
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT BINDING 190
FT /ligand="substrate"
FT /evidence="ECO:0000250"
FT SITE 106
FT /note="Important for catalytic activity"
FT /evidence="ECO:0000250"
SQ SEQUENCE 237 AA; 25435 MW; C3AB6CDDAED4A730 CRC64;
MAQSVTGIQI GGMSFPPSVK PPGSGNTFFL GGAGVRGMEI QGNFVKFTAI GVYLEDKAVP
ALAVKWKGKT AEELTESVEF FREIVTGPFE KFTQVTMILP LTGQQYSEKV SENCVAIWKK
FGIYTDAEAK AIEKFIEVFK DQTFPPGASI LFTQSPDGSL TIGFSKDGCI PEVGNAVIEN
KLLSESVLES IIGKPGVSPE ARKSVATRLS ELLKESDHCV AGNGKVDECT KEAEVKA