ACDE_METBU
ID ACDE_METBU Reviewed; 171 AA.
AC Q12XL6;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-AUG-2006, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
DE Short=ACDS complex subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
DE AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
DE Short=ACDS CODH subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
GN Name=cdhB {ECO:0000255|HAMAP-Rule:MF_01134}; OrderedLocusNames=Mbur_0859;
OS Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 /
OS ACE-M).
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanococcoides.
OX NCBI_TaxID=259564;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 6242 / NBRC 107633 / OCM 468 / ACE-M;
RX PubMed=19404327; DOI=10.1038/ismej.2009.45;
RA Allen M.A., Lauro F.M., Williams T.J., Burg D., Siddiqui K.S.,
RA De Francisci D., Chong K.W., Pilak O., Chew H.H., De Maere M.Z., Ting L.,
RA Katrib M., Ng C., Sowers K.R., Galperin M.Y., Anderson I.J., Ivanova N.,
RA Dalin E., Martinez M., Lapidus A., Hauser L., Land M., Thomas T.,
RA Cavicchioli R.;
RT "The genome sequence of the psychrophilic archaeon, Methanococcoides
RT burtonii: the role of genome evolution in cold adaptation.";
RL ISME J. 3:1012-1035(2009).
CC -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC acetyl-CoA, allowing growth on acetate as sole source of carbon and
CC energy. The alpha-epsilon subcomponent functions as a carbon monoxide
CC dehydrogenase. The precise role of the epsilon subunit is unclear; it
CC may have a stabilizing role within the alpha(2)epsilon(2) component
CC and/or be involved in electron transfer to FAD during a potential FAD-
CC mediated CO oxidation. {ECO:0000255|HAMAP-Rule:MF_01134}.
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
CC {ECO:0000255|HAMAP-Rule:MF_01134}.
CC -!- SUBUNIT: Heterotetramer of two alpha and two epsilon subunits. The ACDS
CC complex is made up of alpha, epsilon, beta, gamma and delta subunits
CC with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-
CC (gamma(1)delta(1))(8). {ECO:0000255|HAMAP-Rule:MF_01134}.
CC -!- SIMILARITY: Belongs to the CdhB family. {ECO:0000255|HAMAP-
CC Rule:MF_01134}.
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DR EMBL; CP000300; ABE51810.1; -; Genomic_DNA.
DR RefSeq; WP_011498963.1; NC_007955.1.
DR AlphaFoldDB; Q12XL6; -.
DR SMR; Q12XL6; -.
DR STRING; 259564.Mbur_0859; -.
DR EnsemblBacteria; ABE51810; ABE51810; Mbur_0859.
DR GeneID; 3996857; -.
DR KEGG; mbu:Mbur_0859; -.
DR HOGENOM; CLU_123700_0_0_2; -.
DR OMA; ITYYYLA; -.
DR OrthoDB; 109783at2157; -.
DR UniPathway; UPA00642; -.
DR Proteomes; UP000001979; Chromosome.
DR GO; GO:0019385; P:methanogenesis, from acetate; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01134; CdhB; 1.
DR InterPro; IPR003704; CO_DH_CoA_synth.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR Pfam; PF02552; CO_dh; 1.
DR PIRSF; PIRSF006035; CO_dh_b_ACDS_e; 1.
DR SUPFAM; SSF52467; SSF52467; 1.
DR TIGRFAMs; TIGR00315; cdhB; 1.
PE 3: Inferred from homology;
KW Methanogenesis; Reference proteome.
FT CHAIN 1..171
FT /note="Acetyl-CoA decarbonylase/synthase complex subunit
FT epsilon"
FT /id="PRO_1000065431"
SQ SEQUENCE 171 AA; 18783 MW; 26C2861A7956AF5B CRC64;
MVDVIKNTQI HCTYGCKSSK AVQPDVAGKM ISKAKRPLFI VGSQILKDEE LLKRSIEIAK
KADLPVAATG HSMSGLVDQG VNAKYINVHA LATYLCDPNW TGLDGKGQYD TIIVLGHFKY
YIDQVLSGLK SFSKLKSIAI EREYIQNATM SFGNITPAVH IEALDELIDN L
