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CFI_CANGE
ID   CFI_CANGE               Reviewed;         226 AA.
AC   Q3Y4F4; Q3Y4F3;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   27-SEP-2005, sequence version 1.
DT   03-AUG-2022, entry version 47.
DE   RecName: Full=Chalcone--flavanone isomerase;
DE            Short=Chalcone isomerase;
DE            EC=5.5.1.6;
GN   Name=CHI;
OS   Canna generalis (Canna lily) (Canna glauca x Canna indica).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Zingiberales; Cannaceae; Canna.
OX   NCBI_TaxID=341692;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RA   Li J., Li M.R., Li H.Q.;
RT   "Isolation and characterization of a Canna generalis gene encoding chalcone
RT   flavonone isomerase.";
RL   Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Catalyzes the intramolecular cyclization of bicyclic
CC       chalcones into tricyclic (S)-flavanones. Responsible for the
CC       isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone)
CC       into naringenin (By similarity). {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a chalcone = a flavanone.; EC=5.5.1.6;
CC   -!- PATHWAY: Secondary metabolite biosynthesis; flavonoid biosynthesis.
CC   -!- MISCELLANEOUS: Part of the biosynthetic pathway for all classes of
CC       flavonoids, a large class of secondary plant metabolites, many of which
CC       are brightly colored.
CC   -!- SIMILARITY: Belongs to the chalcone isomerase family. {ECO:0000305}.
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DR   EMBL; DQ160231; AAZ80910.1; -; Genomic_DNA.
DR   EMBL; DQ160232; AAZ80911.1; -; mRNA.
DR   AlphaFoldDB; Q3Y4F4; -.
DR   SMR; Q3Y4F4; -.
DR   UniPathway; UPA00154; -.
DR   GO; GO:0045430; F:chalcone isomerase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 1.10.890.20; -; 1.
DR   Gene3D; 3.50.70.10; -; 1.
DR   InterPro; IPR044164; CFI.
DR   InterPro; IPR016087; Chalcone_isomerase.
DR   InterPro; IPR016088; Chalcone_isomerase_3-sand.
DR   InterPro; IPR016089; Chalcone_isomerase_bundle_sf.
DR   InterPro; IPR036298; Chalcone_isomerase_sf.
DR   PANTHER; PTHR28039; PTHR28039; 1.
DR   Pfam; PF02431; Chalcone; 1.
DR   SUPFAM; SSF54626; SSF54626; 1.
PE   2: Evidence at transcript level;
KW   Flavonoid biosynthesis; Isomerase.
FT   CHAIN           1..226
FT                   /note="Chalcone--flavanone isomerase"
FT                   /id="PRO_0000314570"
FT   BINDING         51
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         116
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   BINDING         194
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250"
FT   SITE            109
FT                   /note="Important for catalytic activity"
FT                   /evidence="ECO:0000250"
FT   CONFLICT        66
FT                   /note="G -> A (in Ref. 1; AAZ80911)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   226 AA;  24228 MW;  F954066B1C11D07B CRC64;
     MAQAGVSLPK LVIGEVTFPP AAAPPGSSSS LFLAGAGERG LEIDRQFVVF TAIGVYLEDL
     AVSTLGPKWK GKTADDLAGN SDFFRDIFTG PFEKFTRITM VKPLSGQQYS EKVEENCVAH
     WKAAGTYTEA EAAAVEKFKE ACKNETFPPG TSILFTHQVS PASLTITFWR EGSMPETGNT
     VIESKALSEA ILESIIGKHG VSPGAKRSVA QRLSEILEEV KLEGSK
 
 
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