ID   ACDE_METKA              Reviewed;         159 AA.
AC   Q8TXF6;
DT   21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2002, sequence version 1.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit epsilon {ECO:0000250|UniProtKB:Q46G05};
DE            Short=ACDS complex subunit epsilon {ECO:0000250|UniProtKB:Q46G05};
DE   AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit epsilon {ECO:0000250|UniProtKB:Q46G05};
DE            Short=ACDS CODH subunit epsilon {ECO:0000250|UniProtKB:Q46G05};
GN   Name=cdhB; OrderedLocusNames=MK0718;
OS   Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938).
OC   Archaea; Euryarchaeota; Methanopyri; Methanopyrales; Methanopyraceae;
OC   Methanopyrus.
OX   NCBI_TaxID=190192;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AV19 / DSM 6324 / JCM 9639 / NBRC 100938;
RX   PubMed=11930014; DOI=10.1073/pnas.032671499;
RA   Slesarev A.I., Mezhevaya K.V., Makarova K.S., Polushin N.N.,
RA   Shcherbinina O.V., Shakhova V.V., Belova G.I., Aravind L., Natale D.A.,
RA   Rogozin I.B., Tatusov R.L., Wolf Y.I., Stetter K.O., Malykh A.G.,
RA   Koonin E.V., Kozyavkin S.A.;
RT   "The complete genome of hyperthermophile Methanopyrus kandleri AV19 and
RT   monophyly of archaeal methanogens.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:4644-4649(2002).
CC   -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC       acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon
CC       subcomponent functions as a carbon monoxide dehydrogenase. The precise
CC       role of the epsilon subunit is unclear; it may have a stabilizing role
CC       within the alpha(2)epsilon(2) component and/or be involved in electron
CC       transfer to FAD during a potential FAD-mediated CO oxidation.
CC       {ECO:0000250|UniProtKB:Q46G05}.
CC   -!- SUBUNIT: Heterotetramer of two alpha and two epsilon subunits. The ACDS
CC       complex is made up of alpha, epsilon, beta, gamma and delta subunits
CC       with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-
CC       (gamma(1)delta(1))(8). {ECO:0000250|UniProtKB:Q46G05}.
CC   -!- SIMILARITY: Belongs to the CdhB family. {ECO:0000305}.
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DR   EMBL; AE009439; AAM01932.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8TXF6; -.
DR   SMR; Q8TXF6; -.
DR   EnsemblBacteria; AAM01932; AAM01932; MK0718.
DR   KEGG; mka:MK0718; -.
DR   HOGENOM; CLU_1656877_0_0_2; -.
DR   Proteomes; UP000001826; Chromosome.
DR   GO; GO:0019385; P:methanogenesis, from acetate; IEA:InterPro.
DR   InterPro; IPR003704; CO_DH_CoA_synth.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   Pfam; PF02552; CO_dh; 1.
DR   SUPFAM; SSF52467; SSF52467; 1.
PE   3: Inferred from homology;
KW   Reference proteome.
FT   CHAIN           1..159
FT                   /note="Acetyl-CoA decarbonylase/synthase complex subunit
FT                   epsilon"
FT                   /id="PRO_0000155091"
SQ   SEQUENCE   159 AA;  17887 MW;  B26BF2865579C13A CRC64;
     MPLPRDPTLI YTDKAEVARA PVLKMVFRRA NDSLMIVGPR AVEDEEWREL LMKLREEFRM
     SAVCTAPYKG NDLGRKMGIV EAATLLQRDA PVLGVHPDLV VFTGSRTDVT DRVLQGLRHA
     RPDLVKVSLN PEYCPSADYS LPTVKRDQFL QELKALVGI