ACDE_METTH
ID ACDE_METTH Reviewed; 173 AA.
AC O27744;
DT 21-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 25-MAY-2022, entry version 97.
DE RecName: Full=Acetyl-CoA decarbonylase/synthase complex subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
DE Short=ACDS complex subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
DE AltName: Full=ACDS complex carbon monoxide dehydrogenase subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
DE Short=ACDS CODH subunit epsilon {ECO:0000255|HAMAP-Rule:MF_01134};
GN Name=cdhB {ECO:0000255|HAMAP-Rule:MF_01134}; OrderedLocusNames=MTH_1709;
OS Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM
OS 10044 / NBRC 100330 / Delta H) (Methanobacterium thermoautotrophicum).
OC Archaea; Euryarchaeota; Methanomada group; Methanobacteria;
OC Methanobacteriales; Methanobacteriaceae; Methanothermobacter.
OX NCBI_TaxID=187420;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H;
RX PubMed=9371463; DOI=10.1128/jb.179.22.7135-7155.1997;
RA Smith D.R., Doucette-Stamm L.A., Deloughery C., Lee H.-M., Dubois J.,
RA Aldredge T., Bashirzadeh R., Blakely D., Cook R., Gilbert K., Harrison D.,
RA Hoang L., Keagle P., Lumm W., Pothier B., Qiu D., Spadafora R., Vicare R.,
RA Wang Y., Wierzbowski J., Gibson R., Jiwani N., Caruso A., Bush D.,
RA Safer H., Patwell D., Prabhakar S., McDougall S., Shimer G., Goyal A.,
RA Pietrovski S., Church G.M., Daniels C.J., Mao J.-I., Rice P., Noelling J.,
RA Reeve J.N.;
RT "Complete genome sequence of Methanobacterium thermoautotrophicum deltaH:
RT functional analysis and comparative genomics.";
RL J. Bacteriol. 179:7135-7155(1997).
CC -!- FUNCTION: Part of a complex that catalyzes the reversible cleavage of
CC acetyl-CoA, allowing growth on acetate as sole source of carbon and
CC energy. The alpha-epsilon subcomponent functions as a carbon monoxide
CC dehydrogenase. The precise role of the epsilon subunit is unclear; it
CC may have a stabilizing role within the alpha(2)epsilon(2) component
CC and/or be involved in electron transfer to FAD during a potential FAD-
CC mediated CO oxidation. {ECO:0000255|HAMAP-Rule:MF_01134}.
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from acetate.
CC {ECO:0000255|HAMAP-Rule:MF_01134}.
CC -!- SUBUNIT: Heterotetramer of two alpha and two epsilon subunits. The ACDS
CC complex is made up of alpha, epsilon, beta, gamma and delta subunits
CC with a probable stoichiometry of (alpha(2)epsilon(2))(4)-beta(8)-
CC (gamma(1)delta(1))(8). {ECO:0000255|HAMAP-Rule:MF_01134}.
CC -!- SIMILARITY: Belongs to the CdhB family. {ECO:0000255|HAMAP-
CC Rule:MF_01134}.
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DR EMBL; AE000666; AAB86181.1; -; Genomic_DNA.
DR PIR; F69095; F69095.
DR AlphaFoldDB; O27744; -.
DR SMR; O27744; -.
DR STRING; 187420.MTH_1709; -.
DR EnsemblBacteria; AAB86181; AAB86181; MTH_1709.
DR KEGG; mth:MTH_1709; -.
DR PATRIC; fig|187420.15.peg.1670; -.
DR HOGENOM; CLU_123700_0_0_2; -.
DR OMA; ITYYYLA; -.
DR UniPathway; UPA00642; -.
DR Proteomes; UP000005223; Chromosome.
DR GO; GO:0019385; P:methanogenesis, from acetate; IEA:UniProtKB-UniPathway.
DR HAMAP; MF_01134; CdhB; 1.
DR InterPro; IPR003704; CO_DH_CoA_synth.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR Pfam; PF02552; CO_dh; 1.
DR PIRSF; PIRSF006035; CO_dh_b_ACDS_e; 1.
DR SUPFAM; SSF52467; SSF52467; 1.
DR TIGRFAMs; TIGR00315; cdhB; 1.
PE 3: Inferred from homology;
KW Reference proteome.
FT CHAIN 1..173
FT /note="Acetyl-CoA decarbonylase/synthase complex subunit
FT epsilon"
FT /id="PRO_0000155097"
SQ SEQUENCE 173 AA; 19558 MW; CA692918D1A95AA6 CRC64;
MIVLNDRIIP WQPTVIAGPK QAMLVTPETA TMMIKKARRP LMVVGPLAKR QEVLEHTVKI
IRHFDLPVVA TADTYRALSE AGIESEPHGI VEITNLLKDP SWEGIRGEGQ HDLVIFIGCI
YYIASQGLSS LKHFAPHIKT LTICKTFHSN ADASFPNMDD DEWFRYLEKM YAE
