CFM9_ARATH
ID CFM9_ARATH Reviewed; 491 AA.
AC Q9LT57;
DT 16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=CRM-domain containing factor CFM9, mitochondrial {ECO:0000305};
DE AltName: Full=Protein CRM FAMILY MEMBER 9 {ECO:0000303|PubMed:31359042};
DE Flags: Precursor;
GN Name=CFM9 {ECO:0000303|PubMed:31359042};
GN OrderedLocusNames=At3g27550 {ECO:0000312|Araport:AT3G27550};
GN ORFNames=MMJ24.10 {ECO:0000312|EMBL:BAB01285.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=31359042; DOI=10.1093/pcp/pcz147;
RA Lee K., Park S.J., Park Y.I., Kang H.;
RT "CFM9, a mitochondrial CRM protein, is crucial for mitochondrial intron
RT splicing, mitochondria function, and Arabidopsis growth and stress
RT responses.";
RL Plant Cell Physiol. 60:2538-2548(2019).
CC -!- FUNCTION: Involved in the splicing of group II introns in mitochondria
CC (PubMed:31359042). Required for the splicing of mitochondrial introns
CC found in nad1, nad2, nad4, nad5, nad7, rps3 and cox2 genes
CC (PubMed:31359042). Splicing of mitochondrial introns is crucial for
CC mitochondrial biogenesis and function, plant growth and development,
CC and plant response to abiotic stresses (PubMed:31359042).
CC {ECO:0000269|PubMed:31359042}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000269|PubMed:31359042}.
CC -!- TISSUE SPECIFICITY: Highly expressed in roots and meristemic regions of
CC young seedlings (PubMed:31359042). Expressed at low levels in stems,
CC trichomes and stigma (PubMed:31359042). {ECO:0000269|PubMed:31359042}.
CC -!- DISRUPTION PHENOTYPE: Delayed seed germination, retarded growth and
CC reduced size and height. {ECO:0000269|PubMed:31359042}.
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DR EMBL; AB025626; BAB01285.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77336.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65985.1; -; Genomic_DNA.
DR RefSeq; NP_001319656.1; NM_001338891.1.
DR RefSeq; NP_189392.1; NM_113671.3.
DR AlphaFoldDB; Q9LT57; -.
DR SMR; Q9LT57; -.
DR STRING; 3702.AT3G27550.1; -.
DR iPTMnet; Q9LT57; -.
DR PaxDb; Q9LT57; -.
DR PRIDE; Q9LT57; -.
DR ProteomicsDB; 181725; -.
DR EnsemblPlants; AT3G27550.1; AT3G27550.1; AT3G27550.
DR EnsemblPlants; AT3G27550.3; AT3G27550.3; AT3G27550.
DR GeneID; 822377; -.
DR Gramene; AT3G27550.1; AT3G27550.1; AT3G27550.
DR Gramene; AT3G27550.3; AT3G27550.3; AT3G27550.
DR KEGG; ath:AT3G27550; -.
DR Araport; AT3G27550; -.
DR TAIR; locus:2091458; AT3G27550.
DR eggNOG; KOG1990; Eukaryota.
DR HOGENOM; CLU_032610_0_0_1; -.
DR InParanoid; Q9LT57; -.
DR OMA; CSRTCKW; -.
DR PhylomeDB; Q9LT57; -.
DR PRO; PR:Q9LT57; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LT57; baseline and differential.
DR GO; GO:0005739; C:mitochondrion; IDA:UniProtKB.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0000373; P:Group II intron splicing; IMP:UniProtKB.
DR GO; GO:0140040; P:mitochondrial polycistronic RNA processing; IMP:UniProtKB.
DR GO; GO:0009737; P:response to abscisic acid; IMP:UniProtKB.
DR GO; GO:0009651; P:response to salt stress; IMP:UniProtKB.
DR GO; GO:0009414; P:response to water deprivation; IMP:UniProtKB.
DR Gene3D; 3.30.110.60; -; 1.
DR InterPro; IPR040286; At3g25440-like.
DR InterPro; IPR001890; RNA-binding_CRM.
DR InterPro; IPR035920; YhbY-like_sf.
DR PANTHER; PTHR31426; PTHR31426; 2.
DR Pfam; PF01985; CRS1_YhbY; 1.
DR SMART; SM01103; CRS1_YhbY; 1.
DR SUPFAM; SSF75471; SSF75471; 1.
DR PROSITE; PS51295; CRM; 1.
PE 2: Evidence at transcript level;
KW Mitochondrion; mRNA processing; mRNA splicing; Reference proteome;
KW Ribonucleoprotein; RNA-binding; Transit peptide.
FT TRANSIT 1..25
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 26..491
FT /note="CRM-domain containing factor CFM9, mitochondrial"
FT /id="PRO_0000448354"
FT DOMAIN 90..187
FT /note="CRM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00626"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 255..287
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 328..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 20..34
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 255..274
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..420
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..476
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 477..491
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 491 AA; 57003 MW; 39C405151A36DA40 CRC64;
MNQVFKGWSR GMSTSRGRSM RSKVESRMRK ESGKTLREIR RAKKLKKKLM TDEERLIYNL
KRAKKKVALL LQKLKKYDLP ELPSPVHDPE LFTSEQVQAF KKIGFKNKNY VPVGVRGVFG
GVVQNMHMHW KFHETVQVCC DNFPKEKIKE MASMIARLSG GVVINIHNVK TIIMFRGRNY
RQPKNLIPVN TLTKRKALFK ARFEQALESQ KLNIKKTEQQ LRRMGVNPED PVAMASIHRV
ASTFFNAIDK KEGTPYVFHG DKQSERGTSV DNREESEPGD EDSDQEELDR FIAEIEEAAD
KEWEEEEAAE QEESGRIRYW NREEFAGRSR TPELRSYGDA SHGFRRNDRD THSQRRPNDS
DDDDDDGELD SEDDEIPKRF DRARSSNTNT RRPREDFKRR SPDPRPRPRA QVRSDDDVLS
DLDNTMWDSE DEEDAPPANY ISSSDDDEDE NRTVSASSSK QSRFRNNSSR DGINNSKSKS
GKQRDEDWDS D
