ID   CFP6_MYCTU              Reviewed;         112 AA.
AC   P9WIR1; L0TBA1; O53251; P0A5P2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 31.
DE   RecName: Full=Low molecular weight protein antigen 6;
DE   AltName: Full=CFP-6;
GN   Name=cfp6; OrderedLocusNames=Rv3004; ORFNames=MTV012.18;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   PROTEIN SEQUENCE OF 5-16, AND SUBCELLULAR LOCATION.
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=10812229; DOI=10.1016/s0264-410x(00)00049-9;
RA   Bhaskar S., Khanna S.P., Mukherjee R.;
RT   "Isolation, purification and immunological characterization of novel low
RT   molecular weight protein antigen CFP 6 from culture filtrate of M.
RT   tuberculosis.";
RL   Vaccine 18:2856-2866(2000).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10812229}.
CC   -!- CAUTION: The initiator methionine may be further upstream making the
CC       sequence a precursor. {ECO:0000305}.
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DR   EMBL; AL123456; CCP45810.1; -; Genomic_DNA.
DR   PIR; G70855; G70855.
DR   RefSeq; NP_217520.1; NC_000962.3.
DR   RefSeq; WP_003415170.1; NC_000962.3.
DR   AlphaFoldDB; P9WIR1; -.
DR   STRING; 83332.Rv3004; -.
DR   PaxDb; P9WIR1; -.
DR   DNASU; 887891; -.
DR   GeneID; 887891; -.
DR   KEGG; mtu:Rv3004; -.
DR   PATRIC; fig|83332.111.peg.3348; -.
DR   TubercuList; Rv3004; -.
DR   eggNOG; ENOG5033EBJ; Bacteria.
DR   OMA; RISPMAH; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005576; C:extracellular region; HDA:MTBBASE.
DR   InterPro; IPR019692; DUF2581.
DR   Pfam; PF10756; bPH_6; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Secreted.
FT   CHAIN           1..112
FT                   /note="Low molecular weight protein antigen 6"
FT                   /id="PRO_0000089575"
FT   CONFLICT        9
FT                   /note="L -> F (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   112 AA;  12223 MW;  0094564796B29AEB CRC64;
     MAHFAVGFLT LGLLVPVLTW PVSAPLLVIP VALSASIIRL RTLADERGVT VRTLVGSRAV
     RWDDIDGLRF HRGSWARATL KDGTELRLPA VTFATLPHLT EASSGRVPNP YR