ID   CFPA_TREPA              Reviewed;         678 AA.
AC   Q56336;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Cytoplasmic filament protein A;
GN   Name=cfpA; Synonyms=tpn83; OrderedLocusNames=TP_0748;
OS   Treponema pallidum (strain Nichols).
OC   Bacteria; Spirochaetes; Spirochaetales; Treponemataceae; Treponema.
OX   NCBI_TaxID=243276;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-22 AND
RP   147-162.
RC   STRAIN=Nichols;
RX   PubMed=8655496; DOI=10.1128/jb.178.11.3177-3187.1996;
RA   You Y., Elmore S., Colton L.L., Mackenzie C., Stoops J.K., Weinstock G.M.,
RA   Norris S.J.;
RT   "Characterization of the cytoplasmic filament protein gene (cfpA) of
RT   Treponema pallidum subsp. pallidum.";
RL   J. Bacteriol. 178:3177-3187(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Nichols;
RX   PubMed=9665876; DOI=10.1126/science.281.5375.375;
RA   Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
RA   Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
RA   Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
RA   Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M., Utterback T.R.,
RA   McDonald L.A., Artiach P., Bowman C., Cotton M.D., Fujii C., Garland S.A.,
RA   Hatch B., Horst K., Roberts K.M., Sandusky M., Weidman J.F., Smith H.O.,
RA   Venter J.C.;
RT   "Complete genome sequence of Treponema pallidum, the syphilis spirochete.";
RL   Science 281:375-388(1998).
CC   -!- FUNCTION: Component of the cytoplasmic filaments that run the length of
CC       the organism just underneath the cytoplasmic membrane.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Note=An array of 4 to 6 filaments lie
CC       in close apposition to the inner membrane and are always localized
CC       directly underneath the corresponding group of periplasmic flagella.
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DR   EMBL; U32683; AAB07757.1; -; Genomic_DNA.
DR   EMBL; AE000520; AAC65715.1; -; Genomic_DNA.
DR   PIR; A71287; A71287.
DR   RefSeq; WP_010882193.1; NC_021490.2.
DR   AlphaFoldDB; Q56336; -.
DR   SMR; Q56336; -.
DR   IntAct; Q56336; 1.
DR   STRING; 243276.TPANIC_0748; -.
DR   PRIDE; Q56336; -.
DR   EnsemblBacteria; AAC65715; AAC65715; TP_0748.
DR   KEGG; tpa:TP_0748; -.
DR   eggNOG; ENOG5033SJ6; Bacteria.
DR   HOGENOM; CLU_404807_0_0_12; -.
DR   OMA; TSKMGYQ; -.
DR   OrthoDB; 130662at2; -.
DR   Proteomes; UP000000811; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IDA:CACAO.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Direct protein sequencing; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:8655496"
FT   CHAIN           2..678
FT                   /note="Cytoplasmic filament protein A"
FT                   /id="PRO_0000089576"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..678
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          24..49
FT                   /evidence="ECO:0000255"
FT   COILED          290..311
FT                   /evidence="ECO:0000255"
FT   COILED          397..417
FT                   /evidence="ECO:0000255"
FT   COILED          522..540
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   678 AA;  78539 MW;  7910E2AE8A03A41F CRC64;
     MASLDLPKSP NVFHPEKPSA VGSRNSLAQD CRDQQQEVNQ LIEEETNKIL HHLNTKLPKE
     VLERLDVMGG LKEKLYNYFN QNYQNMFNRY MVTAEDEMLK KVRGFIDREE MKVLNRYTPK
     EIAILLDEVA GADKFNTGEI EKSMVNMYGH LQGHIQRGVN ELETHTNSLL RQKVDVGAFV
     RGENAYAVVK CAFKDNLARP KTVTDVKLSI NILDSELVSP IFHYQTTVAY LIKDLISNHY
     IDAIDKEIDR VKDELIDQGK EEMSDSSIIF EKMKMVSDFT DDDCENPDSK RYELISRELM
     ERISNLRAEI DPETFDQLNV RENIKKIVDL ENIRNRGFNT AINSITSILD TSRMGYQYIE
     NFKNARELIL REYDDTDISN LPDERYQLRL KYLDNAQLIE ERKGYEVMLR SFETEVDHLW
     DVLRTKYDKS KASRFMAKIT DFDDLAKVYK KHIKKHYKDK TGEPVYEDIA KVWDEIAFVK
     PAETEVERMN RTFVYEKDKM RRKLILMRGK LKGMYDYQYP IERRVMEERL AFLESEFNRF
     DYLVNPFHLQ PGLLLDIDIT SIKRKKATLD GMANVLNEFL HGISKGFADA AFASFSRRRS
     TVRADIGQSF ASDGSADQKE SSGRVAFMDM VNETPALESS VAAEQVDVRS DVGMKTRKAG
     AVDAGKGRRG RRSAIREL