ID   CFT1_ASPCL              Reviewed;        1401 AA.
AC   A1C3U1;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Protein cft1;
DE   AltName: Full=Cleavage factor two protein 1;
GN   Name=cft1; ORFNames=ACLA_057370;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; DS026990; EAW15081.1; -; Genomic_DNA.
DR   RefSeq; XP_001276507.1; XM_001276506.1.
DR   AlphaFoldDB; A1C3U1; -.
DR   SMR; A1C3U1; -.
DR   STRING; 5057.CADACLAP00005545; -.
DR   EnsemblFungi; EAW15081; EAW15081; ACLA_057370.
DR   GeneID; 4708924; -.
DR   KEGG; act:ACLA_057370; -.
DR   VEuPathDB; FungiDB:ACLA_057370; -.
DR   eggNOG; KOG1896; Eukaryota.
DR   HOGENOM; CLU_002414_2_1_1; -.
DR   OMA; PMTKFKL; -.
DR   OrthoDB; 360328at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1401
FT                   /note="Protein cft1"
FT                   /id="PRO_0000290621"
FT   REGION          181..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          444..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..205
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        444..458
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1401 AA;  153931 MW;  116BF043E53661B8 CRC64;
     MQCYTELLPP TGVTHSLSIP FLSATATNLV VVKTSVLQIF SLLNVSCSAE GEIIAAKSAR
     PDQLQSTKLI LEREYSLSGT VSDLCRVKLL KTKSGGDAIL LAFRNAKLSL VEWDPERYGI
     STISIHYYER DDITRSPWVP DLSSCGSILS VDPSSRCAVF NFGIRNLAIL PFHQPGDDLV
     MGDYESDSQK QSHEHEMDDS AGNSKSKEGA VHQTPYASSF VLPLTALDSA ILHPVSLAFL
     YEYREPTFGI LYSQIATSNS LLHERKDAIF YTVFTLDLEQ RASTMLLSVT RLPSDLFKVV
     ALPPPVGGAL LIGYNELVHV DQAGKTNAVG VNEFSRQVST FSMADQSELA LRLEGCVVEL
     LGNSSGDLLL ALSSGTMVLV HFKLDGRSVS GISIRPLPGH AGGNILKAAA SASASLGSDK
     VFFGSEDAES VLLGWSLSSS NARKSRSESK RIEKDHEEGS DDSESEEDVY EDDLYSAAPD
     TPALGHRLSV APSTFASYKF KVHDVLPNTA PLRDIALGQP AMPVEDTGSH LDNICSELEL
     VAAYGSNGNG GLVVMKRELE PVVKASLNVG PIHGVWTASI ALGSAAKPMS GDQTNIEEWR
     QYVILTKPQT IDKEESEVFI VDGLNLKPFK APEFNPNNDI SIQVGTLSNR KRVVQVLRNE
     VRSYDSDLEL AQIYPVWDED TSDERMALSA SLADPYIAIL RDDSTLLLLQ ADDSGDLDEL
     DMSDILGNEK WLSCCLYWDT THIFSPRGHA SQQSTDCGLL LFLLSTDCRL FIYRLPEQQL
     MSVIEGVDCL PPILSTELPK RSTTREILSE AIVANLGDSW NPLPHLILRT DNDDLVIYKP
     FISSVEEDGD PHCLRFVKET NHVLPRIPPD SDTNISDKEP SNHRPLCILP DISGYSAVFM
     PGTSASFIFK TSRSCPHILR LRGGVVRSLS DFDFTDPSLG RGFIYVDSKD VVRICQLPPE
     TIYDYSWTLK KVAIGEHVDH LAYSISSETY VLGTSHSADF KLPEDDELHP EWRNEAISFL
     PELRQCCLKV VHPKTWTVID SYTLGPDEEI MAVKNMNLEV SENTHERKNM IVVGTALARG
     EDIPARGCIY VFEVIKVVPD PEKPETDRKL KLIGKELVKG AVTALSEIGG QGFLIAAQGQ
     KCMVRGLKED GSLLPVAFMD VQCYVNVLKE LKGTGMCIVG DAFKGIWFAG YSEEPYKMSL
     FGKDLEYPEV VAADFLPDGD KLFILVADSD CNLHVLQYEP EDPMSSNGDK LLVRSKFHMG
     HFTSTLTLLP RTTASYEIPS ADSDSMEVDP RITPQQVLIT SQSGSIGIVT SIPEESYRRL
     SALQSQLANT VEHPCGLNPR AYRAIESDGT AGRGMLDGNL LYQWLSMSKQ RRMEIAARVG
     AHEWEIKADL EAVGGDGLGY L