CFT1_ASPFU
ID CFT1_ASPFU Reviewed; 1401 AA.
AC Q4WCL1;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 2.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Protein cft1;
DE AltName: Full=Cleavage factor two protein 1;
GN Name=cft1; ORFNames=AFUA_8G04040;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC factor (CPF) complex, which plays a key role in polyadenylation-
CC dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC site recognition. May be involved in coupling transcription termination
CC and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR EMBL; AAHF01000013; EAL85173.2; -; Genomic_DNA.
DR RefSeq; XP_747211.2; XM_742118.2.
DR AlphaFoldDB; Q4WCL1; -.
DR SMR; Q4WCL1; -.
DR STRING; 746128.CADAFUBP00008129; -.
DR EnsemblFungi; EAL85173; EAL85173; AFUA_8G04040.
DR GeneID; 3504725; -.
DR KEGG; afm:AFUA_8G04040; -.
DR eggNOG; KOG1896; Eukaryota.
DR HOGENOM; CLU_002414_2_1_1; -.
DR InParanoid; Q4WCL1; -.
DR OMA; PMTKFKL; -.
DR OrthoDB; 360328at2759; -.
DR Proteomes; UP000002530; Chromosome 8.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR Pfam; PF03178; CPSF_A; 1.
DR Pfam; PF10433; MMS1_N; 1.
PE 3: Inferred from homology;
KW mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT CHAIN 1..1401
FT /note="Protein cft1"
FT /id="PRO_0000290622"
FT REGION 434..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 458..474
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1401 AA; 154611 MW; B43E5464308BF759 CRC64;
MQCYTELLSP SGVTHALAIP FLSASAENLV VVKTSVLQIF SLLKVQHHSR GETIETKSAR
PDQVETTKLV LEREYPLSGT VVDICRVKIL NSKSGGEALL LAFRNAKLSL VEWDPERHGI
STISIHYYER DDLTRSPWVP DLSSCGSILS VDPSSRCAVF NFGIRNLAIL PFHQPGDDLA
MDDYEFHLHQ DDLNQVSDHV GNGLKSKDST VYQTPYASSF VLPLTALDPS ILHPVSLAFL
YEYREPTFGI LYSQIATSHA LLSERKDSIF YTVFTLDLEQ RASTTLLSVP KLPSDLFKVV
ALPPPVGGAL LIGSNELVHV DQAGKTNAVG VNEFARQVSA FSMVDQSDLA LRLEGCVVEH
ISDSTGDLLL VLSSGNMVLV HFQLDGRSVS GISLRPLPTQ AGGTIMKSAA SSSAFLGSGR
VFFGSEDADS VLLSWSSMPN PKKSRPRMSN VAEDREEASD DSQSEEDAYE DDLYTAEPET
PALGRRPSAE TTGVGAYIFQ TLDRLPNIGP LRDITLGKPA STVENTGRLI KNACSELELV
AAQGSGRNGG LVLMKREIEP DVTASFDAQS VQEVWTAVVA LGSGAPLVLD EQQINQEYRQ
YVILSKPETP DKETSEVFIA DTQDLKPFRA PEFNPNNDVT IEIGTLSCKK RVVQVLRNEV
RSYDIDLGLA QIYPVWDEDT SDERMAVSAS LADPYIAILR DDSTLMILQA DDSGDLDEVE
LNEAARAGKW RSCCLYWDKA EFFSSTGPAL KQGTRCELFL FLLSIDCRLY VYRLPDQQLI
SVIEGIDCLP PILSTELPKR STTREVLSEA VIADLGESWN PSPHLILRTE SDDLVIYKAF
ASYIKGESHT RLSFVKESNH TLPRVTTSEK EMQSNEKLSR PRSLRILPNI SNFSAVFMPG
RPASFILKTA KSCPHVFRLR GEFVRSLSIF DLASPSLDTG FIYVDSKDVL RICRFPSETL
FDYTWALRKI SIGEQVDHLA YATSSETYVL GTSHSADFKL PDDDELHPDW RNEGLVISFL
PELRQCSLKV VSPRTWTVID SYSLGPDEYV MAVKNMDLEV SENTHERRNM IVVGTAFARG
EDIPSRGCIY VFEVIKVVPD PEKPETDRKL KLIGKELVKG AVTALSQIGG QGFLIAAQGQ
KCMVRGLKED GSLLPVAFMD MQCYVNVLKE LKGTGMCIMG DAVKGLWFAG YSEEPYKMSL
FGKDQGYLEV VAAEFLPDGD KLFILVADSD CNLHVLQYDP EDPKSSNGDR LLARSKFHMG
HFATTMTLLP RTMVSSEKAM ANPDSMEIDS QTISQQVLIT SQSGSVGIVT SVPEESYRRL
SALQSQLANS LEHPCGLNPR AYRAVESDGT AGRGMLDGNL LYQWLDMGQH RKMEIAARVG
AHEWEIKADL EAIGAEGLGY L
