ID   CFT1_COCIM              Reviewed;        1387 AA.
AC   Q1E5B0; J3KLB0;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Protein CFT1;
DE   AltName: Full=Cleavage factor two protein 1;
GN   Name=CFT1; ORFNames=CIMG_02253;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; GG704911; EAS36899.3; -; Genomic_DNA.
DR   RefSeq; XP_001248482.1; XM_001248481.2.
DR   AlphaFoldDB; Q1E5B0; -.
DR   SMR; Q1E5B0; -.
DR   STRING; 246410.Q1E5B0; -.
DR   EnsemblFungi; EAS36899; EAS36899; CIMG_02253.
DR   GeneID; 4568108; -.
DR   KEGG; cim:CIMG_02253; -.
DR   VEuPathDB; FungiDB:CIMG_02253; -.
DR   InParanoid; Q1E5B0; -.
DR   OMA; PMTKFKL; -.
DR   OrthoDB; 360328at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1387
FT                   /note="Protein CFT1"
FT                   /id="PRO_0000290627"
FT   REGION          440..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          509..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        454..470
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        472..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1387 AA;  152937 MW;  9F8DD6B411094DB1 CRC64;
     MQCYTELLPP SGVTHAISLP FLSATSNNLI VAKTSILQVF SLVNVAYGTS APPNADDKGR
     VERQQYTKLI LVAEYDLSGT ITGLGRVKIL DSRSGGEALL VSTRNAKLSL VEWDHERHGI
     STISIHYYER EDVHSSPWTP DLRLCPSLLA VDPSSRCAIL NFGIHSVAIL PFHQTGDDLV
     MDEFDEDLDE KPEGASNIPA QAAVANDTTM YKTPYASSFV LPLTALDPAL VHPIHLAFLY
     EYREPTFGIL YSHLTTSSAL LHDRKDIVSY AVFTLDIQQR ASTTLITVSR LPSDLWKVVP
     LPPPIGGALL IGSNELIHVD QAGKTNAVGI NEFARQASAF SMVDQSDLGL RLEGCVVEQL
     GTDSGDILLV LADGKMAILR LKVDGRSVSG ISAQLVSEKA GGSILKARPS CSASLGRGKV
     FFGSEETDSL LIGWSRPSQS MRKPKVESAD DVFGDHSETE DDEDDIYEDD LYSTPVNQTT
     LSKTTSQTNG LNKDDFVFRS HDRLWNLGPM SDVTLGRPPG SHDKNRKQSS SRTSADLELV
     VTQGKGNAGG LAVLQRELDP YVIDSMKMDN VDGVWSIQVG APDSTNTRTS SRNYDKYLVF
     SKSTEPGKEQ SVVYSVGGSG IEEMKAPEFN PNEDSTVDIG TLAGGTRVVQ VLKSEVRSYD
     TNLELAQIYP IWDEDTSDEL SVVSASFAEP YVLIVRDDQS LLLLQADKSG DLDEVNIDGI
     LSSHRWLSGC LYLDKYHTFV PTKGQDQPLS DNILLVLLRA DHTLFIFSLP TLTEPLCSVD
     GVDLLPLILS CEPPPKRVTY RETLSEVLIA DLGDSISRQP YMILRTANDD LILYQPYHPK
     TSLDKPELRF VKIIDHFLPR FDPSPKAYMP HSKFLRAYSD ICGYKTVFMS GSNPCFVMKS
     STSSPHVLRL RGEAVSSLSS FHIPACEKGF AYVDASNMVR MCRLPSNTRF DNSWVTRKVH
     VGDQIDCVEY FAHSEIYALG SSHKVDFKLP EDDEIHPEWR SEVISFMPQL ERGCIKLLSP
     RTWSVVDSYE LGDAERVMCM KTINMEISEI THEMKDMLVV GTATVRGEDI TPRGSIYVFE
     IIEVAPDPDR PETNRKLKIF AKDDVKGAVT AVSGIGGQGF LIMAQGQKCM VRGLKEDGSL
     LPVAFMDMQC YVKVLKELQG TGLCIMGDAL KGIWFAGYSE EPYRLTLFGK DNEYLQVIAA
     DFLPDGKRLY ILVADDDCTI HVLEYDPEDP TSSKGDRLLH RSSFHTGHFT STMTLLPEHS
     SSPSADDPEE DDMDVDYVPK SYQVLVTSQE GSIGVVTPLT EDSYRRLSAL QSQLVTSMEH
     PCGLNPKAYR AVESDGFGGR GIVDGNLLLR WLDMGVQRKA EIAGRVGADI ESIRVDLETI
     SGGLDFL