ID   CFT1_CRYNJ              Reviewed;        1431 AA.
AC   P0CM62; Q55QF1; Q5KFS0;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Protein CFT1;
DE   AltName: Full=Cleavage factor two protein 1;
GN   Name=CFT1; OrderedLocusNames=CNF00780;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; AE017346; AAW44183.1; -; Genomic_DNA.
DR   RefSeq; XP_571490.1; XM_571490.1.
DR   AlphaFoldDB; P0CM62; -.
DR   SMR; P0CM62; -.
DR   STRING; 5207.AAW44183; -.
DR   PaxDb; P0CM62; -.
DR   EnsemblFungi; AAW44183; AAW44183; CNF00780.
DR   GeneID; 3258187; -.
DR   KEGG; cne:CNF00780; -.
DR   VEuPathDB; FungiDB:CNF00780; -.
DR   eggNOG; KOG1896; Eukaryota.
DR   HOGENOM; CLU_002414_0_0_1; -.
DR   InParanoid; P0CM62; -.
DR   OMA; PMTKFKL; -.
DR   OrthoDB; 360328at2759; -.
DR   Proteomes; UP000002149; Chromosome 6.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 3.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1431
FT                   /note="Protein CFT1"
FT                   /id="PRO_0000290628"
FT   REGION          721..759
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1431 AA;  156934 MW;  785C81CCF4E8CBD6 CRC64;
     MHALHQTLLP SSSIHHSLFL PHFTPSTIYP LPKPPAALDT LDVKVIGNLV VAGAEVLRVF
     EIREESVPII ENVKLEEDVA EGEKDVQMEE VGDGFFDDGH AERAPLKYQT TRRLHLLTQH
     ELNGTITGLA ATRTLESTID GLDRLIVSFK DAKMALLEWS RGDIATVSLH TYERCSQMNT
     GDLQSYVPLL RTDPLSRLAV LTLPEDSLAV LPLIQEQSEL DPLSEGFSRD APYSPSFVLS
     LSDMSITIKN IQDLLFLPGF HSPTIALLFS PMHTWSGRLQ TVKDTFCLEI RTFDLSSGTS
     YPLLTSVSGL PSDSLYLVAC PSELGGIVLV TSTGIVHVDQ GGRVTAACVN AWWSRITSLK
     CSMASVSQKL TLEGSRCVFV TPHDMLLVLQ NGAVHQVRFS MEGRAVGVIE VLDKGCVVPP
     PSDLTVAGDG AVFVGSAEGD SWLAKVNVVR QVVERSEKKK DEMEVDWDED LYGDINDAAL
     DEKAQELFGP AAITLSPYDI LTGVGKIMDI EFGIAASDQG LRTYPQLVAV SGGSRNSTIN
     VFRRGIPITK RRRFNELLNA EGVWFLPIDR QTGQKFKDIP EAERATILLS SEGNATRVFA
     LFSKPTPQQI GRLDGKTLSA APFFQRSCIL RVSPLEVVLL DNNGKIIQTV CPRGDGPKIV
     NASISDPFVI IRRADDSVTF FVGDTVARTV AEAPIVSEGE SPVCQAVEVF TDTTGVYRTF
     EPSKSESSEP ISHQIDSENK PNITNGINGT TARSARQTQL TPQQIKRLQE QEPAITTEAP
     SMETAINSPH GTQWLALVTR GGELQIRSLP DLQIVLQSEG LASSAPSFTD DLGENPGYVL
     GEKREEGEEE DEIIQMVFCP IGKGTVRQHL LALHHSGRLN AYEAQPRFTV DASSHSRRSL
     AVRFRKVHTQ LLPISGGVGT TNGNARLPYT IVPFNNIEGL TGAFITGEKP HWIISSEAHP
     LRAFALKQAA MAFGKTTHLG GKGEYFIRIE DGSFICYLPP TLNTDFAIPC DRYQMERAYT
     NITFDPTSAH YVGAASIEVP FQAYDEEGEI QLGPDGPDLI PPTNQRSTLE LFSQGSDPWK
     VIDGYEFDQN EEVMSMESVN LESPGAPGGY RDFIAVGTGF NFGEDRATRG NTYIFEILQT
     VGPQGGGGPG SVPGWKLVKR TKDPARHPVN AVNHINGYLL NTNGPKLYVK GLDYDSQLMG
     LAFLDIQLYA TTVKVFKNFM LIGDLCKSFW FVSLQEDPYK FTTISKDLQH VSVVTADFLV
     HDGQVTFISS DRNGDMRMLD FDPTDPDSLN GERLMLRTEY HAGSAATVSK VIARRKTAEE
     EFAPQTQIIY ATADGALTTV VSVKDARFKR LQLVSDQLVR NAQHVAGLNP RAFRTVRNDL
     LPRPLSKGIL DGQLLNQFAL QPIGRQKEMM RQIGTDAVTV ASDLQALGGF W