ID   CFT1_EMENI              Reviewed;        1339 AA.
AC   Q5BDG7; C8VM26;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Protein cft1;
DE   AltName: Full=Cleavage factor two protein 1;
GN   Name=cft1; ORFNames=AN1413;
OS   Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS   M139) (Aspergillus nidulans).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Nidulantes.
OX   NCBI_TaxID=227321;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=16372000; DOI=10.1038/nature04341;
RA   Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA   Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA   Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA   Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA   Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA   Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA   Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA   Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA   Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT   "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT   fumigatus and A. oryzae.";
RL   Nature 438:1105-1115(2005).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX   PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA   Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA   Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA   Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA   Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA   Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA   Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA   Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA   van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA   Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA   Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA   Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA   Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA   Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA   van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA   Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA   Oliver S.G., Turner G.;
RT   "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT   effort.";
RL   Fungal Genet. Biol. 46:S2-13(2009).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; AACD01000022; EAA64543.1; -; Genomic_DNA.
DR   EMBL; BN001307; CBF84808.1; -; Genomic_DNA.
DR   RefSeq; XP_659017.1; XM_653925.1.
DR   AlphaFoldDB; Q5BDG7; -.
DR   SMR; Q5BDG7; -.
DR   STRING; 162425.CADANIAP00008024; -.
DR   PRIDE; Q5BDG7; -.
DR   EnsemblFungi; CBF84808; CBF84808; ANIA_01413.
DR   EnsemblFungi; EAA64543; EAA64543; AN1413.2.
DR   GeneID; 2875502; -.
DR   KEGG; ani:AN1413.2; -.
DR   eggNOG; KOG1896; Eukaryota.
DR   HOGENOM; CLU_002414_2_1_1; -.
DR   InParanoid; Q5BDG7; -.
DR   OMA; PMTKFKL; -.
DR   OrthoDB; 360328at2759; -.
DR   Proteomes; UP000000560; Chromosome VII.
DR   Proteomes; UP000005890; Unassembled WGS sequence.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1339
FT                   /note="Protein cft1"
FT                   /id="PRO_0000290630"
FT   REGION          436..455
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1339 AA;  146917 MW;  6FE441394E3C646D CRC64;
     MQCYTELISP TGVTHALAVP FLSATANNLI VARTSLLQIF SLRDVSLSAL DTEVRPAQHR
     QETCKLVLER EYQLPGTVTD ICRVKILKTK SGGDAVLVAF RDAKLSLVEW DPERYGLSTI
     SIHYYERDDM TRSPWASDLS TCGSILSADP GSRCAIFQFG ARSLAIIPFH QPGDDLVMDD
     FGSEPDYENR VEGNSRSHEA KDKDAAEYQT PYASSFVLPL TALDPSVIHP ISLAFLYEYR
     EPTFGILYSQ VATSHALLHE RKDVVFYTVI TLDLEQRAST TLLSVTRLPS DLFKVVALPP
     PVGGSLLIGS NELVHIDQAG KTNAVGVNEF SRQASSFSMT DQSDLALRLE NCVVERFSDD
     NGDLLLALST GVFALVSFKL DGRSVSGISV RPLSGPSKEF LASTASSSAF LGNGKVFFGS
     ESADSVLLGW SSASSATKKS FSGSTSNDES EDDAYEDDLY SSAPAAMTDN PQNQPSNSSV
     AAFGDLRIHD RLSSPGPIRD IVLGRSSEAS SRDTKDGVLE LVAAQGSDEG GTMVIMKREV
     DPYLVASMAA DTANSLWTVS LLPDNNDQKR DYVILSKQEK PDKEESEVFV LEDKLRPITA
     PEFNPNHELT VEIGTLASKS RVIQVLRNEV RSYDAVWDED DSDERVAVNA TLVDPYLAII
     RDDSTLLLLQ ADDSGDLDEV TLSEDVVSQK WLSACFYSDN AGFFTAPFAS ILFLLNQDHQ
     LYVYRLPDFA VISVIEGVGC LPPILSTEPP KRSTTRENVL QIAVVELGDS YSSLPFLILR
     TENDDLVVYK PFFTNSKELT GLRFLKEANH TLPKTPNTTD ELQSEMKPLR ILPNIAGCSS
     IFMPGPSAGF IFRASTTSPH FIRLRGGFIK GLGCFDSPDK GFAYLDSHGL HLAKLPEGTQ
     LGYPWIMRTV PIGQQIDKLT YVSASDTYVL GTCQRCEFRL PEDDELHPEW RNEEISFLPE
     VNQSSLKVVS PKTWSVIDSY PLEPAEHIMV MKTMSLEVSE NTHERRDMIV VGTSLARGED
     IPSRGCIYVF EVIEVVPDPE QPETNRRLKL IGKEPVKGAV TALSEIGGQG FLIAAQGQKS
     MVRGLKEDGS LLPVAFMDMQ CFVSVIKELK GTGMCIFGDA VKGLWFAGYS EEPYKMSLFA
     KDLDYLEVLA ADFLPDGNKL FIVVADSDCN LYVLQYDPED PNSSNGDKLL NRSKFHTGNF
     ASTVTLLPRT LVSSERAMSG SDKMDIDNTA PLHQVLVTSH NGSIGLVTCV PEESYRRLSA
     LQSQLTNTLE HPCGLNPRAY RAVESDASAG RGMLDSNLLL QYLDMSKQRK AEIAGRVGAT
     EWEIRADLEA ISGGGLGYL