ID   CFT1_KLULA              Reviewed;        1300 AA.
AC   Q6CTT2;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 88.
DE   RecName: Full=Protein CFT1;
DE   AltName: Full=Cleavage factor two protein 1;
GN   Name=CFT1; OrderedLocusNames=KLLA0C10274g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; CR382123; CAH01508.1; -; Genomic_DNA.
DR   RefSeq; XP_452657.1; XM_452657.1.
DR   AlphaFoldDB; Q6CTT2; -.
DR   SMR; Q6CTT2; -.
DR   STRING; 28985.XP_452657.1; -.
DR   EnsemblFungi; CAH01508; CAH01508; KLLA0_C10274g.
DR   GeneID; 2892237; -.
DR   KEGG; kla:KLLA0_C10274g; -.
DR   eggNOG; KOG1896; Eukaryota.
DR   HOGENOM; CLU_002414_0_0_1; -.
DR   InParanoid; Q6CTT2; -.
DR   OMA; PMTKFKL; -.
DR   Proteomes; UP000000598; Chromosome C.
DR   GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006378; P:mRNA polyadenylation; IEA:EnsemblFungi.
DR   GO; GO:0098789; P:pre-mRNA cleavage required for polyadenylation; IEA:EnsemblFungi.
DR   GO; GO:0006369; P:termination of RNA polymerase II transcription; IEA:EnsemblFungi.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1300
FT                   /note="Protein CFT1"
FT                   /id="PRO_0000290631"
SQ   SEQUENCE   1300 AA;  147932 MW;  5F3E251B7B3B5C8D CRC64;
     MNVFDEILQP TVVNKCLHGN FTSAEREEYV VARTNVLSVF RVSRAQKLVL AYEWKLAGKI
     IDMQLLPQIG SPLKMLAILS SKSKVSLVRF DPVAESLETL SLHYYHDKFV NLSTSSLKTE
     SIMAVDPLFR CLLVFNEDVL AILPLKLNTE DMEIDEDENG IKEPMAKRLK RNQGITSDSI
     IMPISSLHKS LKHVYDIKWL NNFSKPTVGI LYQPVLAWCG NEKVLGNTMR YMVLSLDVED
     EKTTVIAELA DLPNDLHTLV PLKRGYVLIG VNELLYISAS GALQSCIRLN TFATSSINTR
     ITDNSDMNIF LSKSSIYFYK ALKRHDLLIL IDENCRMYNI ITESEGNLLT KFDCVQVPIV
     NEIFKNSRLP LSVCGDLNLE TGRVLIGFLS GDAMFLQLKN LKVAFAAKRQ LVETVDDDDD
     EYSALYGESQ NNTHTRIVET QEPFDISLLD SIFNIGPLTS LTIGKVASVE PTIQRLPNPN
     KDEFSIVATS GVGRGSHLTA LHSTVQPHIE QALKFTSATR IWNLKIKGKD KYLVTTDADK
     EKSDVYQIDR NFEPFRAQDF RKDSRTIGME TMDDDKRILQ VTSGGLYLFD VDFKRLARLT
     IDIEIVHACI IDPYILFTDA RGNIKIYQLD SKNKKKFIKF KLPEALNEII ITSGSIFKSN
     ICNKFLHGLE NSSQEQLLFT FVTGDNQVIF FTEKHNDRIF QLNGVDQLED MLFISTYQIP
     EEMNPDPSIK QIMLNRLGHH KKEEFLTILT FGGEIYQYKK STKHSGKLLK CKSHPLITGA
     PNNAYPQGVN KIERVAHYFP NYNGYSVVFI TGQVPYIIIK EDNSVCRIFR MTNIPIVTMA
     RWGKNSVMCV DNIKNARVMK LDPECYYGNT QILRKIIIED VVEEFETLGN IAYHERTGMY
     IISYTKFIEY QALSEDGEPL VGYDPSKPNS TGYKSGLLLI NPLTWNIIDR LDLSENSMVN
     DIKTMLIQLN SKTRRKRELV IIGSSFVKEE DQPSTGCLLV LDITEVVAEP GKPDSNFKFK
     QLFEEEIRGS VNAVCEISGR FMIGQSSKAL VRDMQEDNSA VPVAFLDMPV FITDAKSFSN
     LMIIGDSMQG FTFVGFDAEP YRMIVLGKST SKFQVMNLEF LVNNGNINFI VTDRQNHLHV
     LRYAPDEANS LSGQRLVHCN SFNMFTTNNY MKLVRKHVEF GSKTSNYIAL GCQTDGSIFR
     MIPLNEASYR RFYLVQQQLL DHEIPLAGFN TKMERLDNEY YHKGHSLRPT LDSQVLKKYI
     HLPITKRTTI ENRVGRHAST ELWHDLIDIE FSLRSLTNSN