ID   CFT1_NEOFI              Reviewed;        1400 AA.
AC   A1DB13;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Protein cft1;
DE   AltName: Full=Cleavage factor two protein 1;
GN   Name=cft1; ORFNames=NFIA_096750;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: RNA-binding component of the cleavage and polyadenylation
CC       factor (CPF) complex, which plays a key role in polyadenylation-
CC       dependent pre-mRNA 3'-end formation and cooperates with cleavage
CC       factors including the CFIA complex and NAB4/CFIB. Involved in poly(A)
CC       site recognition. May be involved in coupling transcription termination
CC       and mRNA 3'-end formation (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CFT1 family. {ECO:0000305}.
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DR   EMBL; DS027694; EAW20053.1; -; Genomic_DNA.
DR   RefSeq; XP_001261950.1; XM_001261949.1.
DR   AlphaFoldDB; A1DB13; -.
DR   SMR; A1DB13; -.
DR   STRING; 36630.CADNFIAP00009148; -.
DR   EnsemblFungi; EAW20053; EAW20053; NFIA_096750.
DR   GeneID; 4588706; -.
DR   KEGG; nfi:NFIA_096750; -.
DR   VEuPathDB; FungiDB:NFIA_096750; -.
DR   eggNOG; KOG1896; Eukaryota.
DR   HOGENOM; CLU_002414_2_1_1; -.
DR   OMA; PMTKFKL; -.
DR   OrthoDB; 360328at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR   Gene3D; 2.130.10.10; -; 2.
DR   InterPro; IPR004871; Cleavage/polyA-sp_fac_asu_C.
DR   InterPro; IPR018846; Cleavage/polyA-sp_fac_asu_N.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   Pfam; PF03178; CPSF_A; 1.
DR   Pfam; PF10433; MMS1_N; 1.
PE   3: Inferred from homology;
KW   mRNA processing; Nucleus; Reference proteome; RNA-binding.
FT   CHAIN           1..1400
FT                   /note="Protein cft1"
FT                   /id="PRO_0000290632"
FT   REGION          436..472
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1400 AA;  154521 MW;  4F57DD4377C784A3 CRC64;
     MQCYTELLPP SGVTHALAIP FISATAENLV VVKTSVLQIF SLLKVQHHLR GGTIEGKSAR
     PDRVETTKLV LEREYPLSGT VVDICRVKIL NPKSGGEALL LAFRNAKLSL VEWDPERHGI
     STLSIHYYER DDLTRSPWVP DLSSCGSILS VDPSSRCAVF NFGIRNLAIL PFHQPGDDLA
     MDDYEFHLHQ DDFNQVSDHV GNDLKSKDRT VYQTPYASSF VLPLTALDPS ILHPVSLAFL
     YEYREPTFGV LYSQIATSHA LLPERKDSIF YTVFTLDLEQ RASTTLLSVP KLPSDLFKVV
     ALPPPVGGAL LIGSNELVHV DQAGKTNAVG VNEFARQVSA FSMVDQSDLA LRLEGCVVEH
     LSDSTGDLLL VLSSGNMVLV HFQLDGRSVS GISLRPLPAQ AGGTIMKSAA SSSAFLGSGR
     VFFGSEDADS VLLSWSSMSS NPKKPRPRMS NVAEDREEAS VDSQSEEDVY EDDLYTAEPE
     TPALGRRPSA ETSGVGVYIF QILDRLPNIG PLRDITLGKP ASTVENTGRL IENACSELEL
     IAAQGSGRNG GLVLMKREIE PDVAASFDAQ SVQGVWTAVV ALGSGAPLVP DEQRINQEYR
     QYVILSKPEA PDKEQSEVFI ADKQDLKPFK APEFNPNNDV TIEIGTLSCK RRVVQVLRNE
     VRSYDIDLGL AQIYPVWDED TSDERMAVSA SLADPYIAIL RDDSTLMLLQ ADDSGDLDEV
     ELDDSTRAGK WRSCCLYWDK AEIFSSTVPT SKQRTHCELF LFLLSIDCRL YVYRLPDQQL
     MSVIEGIDCL PPILSTELPK RSTTREVLSE AVIADLGESW NPSPHLILRT ESDDLVIYKA
     FASSIKGESH THLSFVKETN HTLPRVTTSD KEMQSNEELS RSRSLRILPN ISDLSAVFMP
     GPSASFILKT AKSCPHVFRL RGEFVRGLSI FDLASPSLDK GFIYVDSKDV LRICRFPSET
     LFDYTWALRK IGIGEQVDHL AYATSSETYV LGTSHSADFK LPDDDELHPD WRNEVISFLP
     ELRQCSLKVV SPRTWTVIDS YSLGPAEYVM AVKNMDLEVS ENTHERRNMI VVGTAFAWGE
     DIPSRGCIYV FEVIKVVPDP EKPETDRKLK LIGKELVKGA VTALSQIGGQ GFLIAAQGQK
     CMVRGLKEDG SLLPVAFMDM QCYVNVVKEL KGTGMCIMGD AVKGLWFAGY SEEPYKMSLF
     GKDQGYLEVV AAEFLPDGDK LFILVADSDC NLHVLQYDPE DPKSSNGDRL LARSKFHMGH
     FATTMTLLPR TMVSSEKAMA DPDSMEIDSQ TISQQVLITS QSGSVGIVTS VPEESYRRLS
     ALQSQLTNSL EHPCGLNPRA YRAVESDGTA GRGMLDGNLL YQWLDMGQHR KMEIAARVGA
     HEWEIKADLE AIGAEGLGYL