ID   CFXR_CUPNH              Reviewed;         317 AA.
AC   P42722; Q0K1D9;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 115.
DE   RecName: Full=HTH-type transcriptional regulator CfxR;
DE   AltName: Full=RuBisCO operon transcriptional regulator;
GN   Name=cfxR; Synonyms=cbbR; OrderedLocusNames=H16_B1396;
OS   Cupriavidus necator (strain ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442
OS   / H16 / Stanier 337) (Ralstonia eutropha).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Cupriavidus.
OX   NCBI_TaxID=381666;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1779759; DOI=10.1111/j.1365-2958.1991.tb01978.x;
RA   Windhoevel U., Bowien B.;
RT   "Identification of cfxR, an activator gene of autotrophic CO2 fixation in
RT   Alcaligenes eutrophus.";
RL   Mol. Microbiol. 5:2695-2705(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 17699 / DSM 428 / KCTC 22496 / NCIMB 10442 / H16 / Stanier 337;
RX   PubMed=16964242; DOI=10.1038/nbt1244;
RA   Pohlmann A., Fricke W.F., Reinecke F., Kusian B., Liesegang H., Cramm R.,
RA   Eitinger T., Ewering C., Poetter M., Schwartz E., Strittmatter A., Voss I.,
RA   Gottschalk G., Steinbuechel A., Friedrich B., Bowien B.;
RT   "Genome sequence of the bioplastic-producing 'Knallgas' bacterium Ralstonia
RT   eutropha H16.";
RL   Nat. Biotechnol. 24:1257-1262(2006).
CC   -!- FUNCTION: Trans-acting transcriptional regulator of RuBisCO genes
CC       (cfxLS) expression.
CC   -!- SIMILARITY: Belongs to the LysR transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M65065; AAA21982.1; -; Genomic_DNA.
DR   EMBL; AM260480; CAJ96185.1; -; Genomic_DNA.
DR   PIR; S18583; S18583.
DR   RefSeq; WP_010809288.1; NZ_CP039288.1.
DR   AlphaFoldDB; P42722; -.
DR   SMR; P42722; -.
DR   STRING; 381666.H16_B1396; -.
DR   EnsemblBacteria; CAJ96185; CAJ96185; H16_B1396.
DR   GeneID; 57647294; -.
DR   KEGG; reh:H16_B1396; -.
DR   eggNOG; COG0583; Bacteria.
DR   HOGENOM; CLU_039613_6_1_4; -.
DR   OMA; VCKYYLM; -.
DR   OrthoDB; 750230at2; -.
DR   Proteomes; UP000008210; Chromosome 2.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR005119; LysR_subst-bd.
DR   InterPro; IPR000847; Tscrpt_reg_HTH_LysR.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF00126; HTH_1; 1.
DR   Pfam; PF03466; LysR_substrate; 1.
DR   PRINTS; PR00039; HTHLYSR.
DR   SUPFAM; SSF46785; SSF46785; 1.
DR   PROSITE; PS50931; HTH_LYSR; 1.
PE   3: Inferred from homology;
KW   Activator; DNA-binding; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..317
FT                   /note="HTH-type transcriptional regulator CfxR"
FT                   /id="PRO_0000105609"
FT   DOMAIN          8..65
FT                   /note="HTH lysR-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
FT   DNA_BIND        25..44
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00253"
SQ   SEQUENCE   317 AA;  34826 MW;  77F1B31E9B25D76F CRC64;
     MSSFLRALTL RQLQIFVTVA RHASFVRAAE ELHLTQPAVS MQVKQLESVV GMALFERVKG
     QLTLTEPGDR LLHHASRILG EVKDAEEGLQ AVKDVEQGSI TIGLISTSKY FAPKLLAGFT
     ALHPGVDLRI AEGNRETLLR LLQDNAIDLA LMGRPPRELD AVSEPIAAHP HVLVASPRHP
     LHDAKGFDLQ ELRHETFLLR EPGSGTRTVA EYMFRDHLFT PAKVITLGSN ETIKQAVMAG
     MGISLLSLHT LGLELRTGEI GLLDVAGTPI ERIWHVAHMS SKRLSPASES CRAYLLEHTA
     EFLGREYGGL MPGRRVA