CG025_HUMAN
ID CG025_HUMAN Reviewed; 421 AA.
AC Q9BPX7; A4D1V2; J3KR36; Q9H779;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=UPF0415 protein C7orf25;
GN Name=C7orf25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=17081983; DOI=10.1016/j.cell.2006.09.026;
RA Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.;
RT "Global, in vivo, and site-specific phosphorylation dynamics in signaling
RT networks.";
RL Cell 127:635-648(2006).
CC -!- INTERACTION:
CC Q9BPX7; O00178: GTPBP1; NbExp=3; IntAct=EBI-718586, EBI-4403245;
CC Q9BPX7; P26639: TARS1; NbExp=3; IntAct=EBI-718586, EBI-1042683;
CC Q9BPX7; B2RDX5; NbExp=3; IntAct=EBI-718586, EBI-10173104;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BPX7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BPX7-2; Sequence=VSP_047243;
CC -!- SIMILARITY: Belongs to the UPF0415 family. {ECO:0000305}.
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DR EMBL; AK024820; BAB15019.1; -; mRNA.
DR EMBL; AC010132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236951; EAL24004.1; -; Genomic_DNA.
DR EMBL; BC000769; AAH00769.1; -; mRNA.
DR EMBL; BC001845; AAH01845.1; -; mRNA.
DR CCDS; CCDS47576.1; -. [Q9BPX7-1]
DR CCDS; CCDS5466.1; -. [Q9BPX7-1]
DR RefSeq; NP_001093328.1; NM_001099858.1. [Q9BPX7-1]
DR RefSeq; NP_076959.2; NM_024054.2. [Q9BPX7-1]
DR RefSeq; XP_005249901.1; XM_005249844.3.
DR RefSeq; XP_016868086.1; XM_017012597.1. [Q9BPX7-1]
DR AlphaFoldDB; Q9BPX7; -.
DR SMR; Q9BPX7; -.
DR BioGRID; 122489; 22.
DR IntAct; Q9BPX7; 23.
DR MINT; Q9BPX7; -.
DR STRING; 9606.ENSP00000413029; -.
DR CarbonylDB; Q9BPX7; -.
DR GlyGen; Q9BPX7; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BPX7; -.
DR PhosphoSitePlus; Q9BPX7; -.
DR BioMuta; C7orf25; -.
DR DMDM; 74732797; -.
DR EPD; Q9BPX7; -.
DR jPOST; Q9BPX7; -.
DR MassIVE; Q9BPX7; -.
DR MaxQB; Q9BPX7; -.
DR PaxDb; Q9BPX7; -.
DR PeptideAtlas; Q9BPX7; -.
DR PRIDE; Q9BPX7; -.
DR ProteomicsDB; 78593; -. [Q9BPX7-1]
DR Antibodypedia; 13143; 71 antibodies from 13 providers.
DR DNASU; 79020; -.
DR Ensembl; ENST00000350427.5; ENSP00000343364.4; ENSG00000136197.14. [Q9BPX7-1]
DR Ensembl; ENST00000438029.1; ENSP00000396597.1; ENSG00000136197.14. [Q9BPX7-1]
DR Ensembl; ENST00000447342.5; ENSP00000413029.2; ENSG00000136197.14. [Q9BPX7-2]
DR GeneID; 79020; -.
DR KEGG; hsa:79020; -.
DR MANE-Select; ENST00000350427.5; ENSP00000343364.4; NM_001099858.2; NP_001093328.2.
DR UCSC; uc003thx.5; human. [Q9BPX7-1]
DR CTD; 79020; -.
DR GeneCards; C7orf25; -.
DR HGNC; HGNC:21703; C7orf25.
DR HPA; ENSG00000136197; Low tissue specificity.
DR neXtProt; NX_Q9BPX7; -.
DR PharmGKB; PA134976499; -.
DR VEuPathDB; HostDB:ENSG00000136197; -.
DR VEuPathDB; HostDB:ENSG00000256646; -.
DR eggNOG; KOG4529; Eukaryota.
DR GeneTree; ENSGT00390000014722; -.
DR HOGENOM; CLU_054053_0_0_1; -.
DR InParanoid; Q9BPX7; -.
DR OMA; EGHQKLC; -.
DR OrthoDB; 1139278at2759; -.
DR PhylomeDB; Q9BPX7; -.
DR TreeFam; TF105980; -.
DR PathwayCommons; Q9BPX7; -.
DR SignaLink; Q9BPX7; -.
DR BioGRID-ORCS; 79020; 18 hits in 1064 CRISPR screens.
DR ChiTaRS; C7orf25; human.
DR GenomeRNAi; 79020; -.
DR Pharos; Q9BPX7; Tdark.
DR PRO; PR:Q9BPX7; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BPX7; protein.
DR Bgee; ENSG00000136197; Expressed in monocyte and 98 other tissues.
DR ExpressionAtlas; Q9BPX7; baseline and differential.
DR Genevisible; Q9BPX7; HS.
DR InterPro; IPR010733; DUF1308.
DR InterPro; IPR041076; DUF5614.
DR Pfam; PF07000; DUF1308; 1.
DR Pfam; PF18474; DUF5614; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..421
FT /note="UPF0415 protein C7orf25"
FT /id="PRO_0000279529"
FT VAR_SEQ 1
FT /note="M -> MQEVPEAAGLARVEPPRRSSGVGAARLRFPGGSRPLRARACVLALAV
FT LALPERNNADSM (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_047243"
FT VARIANT 265
FT /note="G -> E (in dbSNP:rs3735471)"
FT /id="VAR_053848"
FT CONFLICT 131
FT /note="W -> R (in Ref. 1; BAB15019)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 421 AA; 46451 MW; D7C421DC4CA80E9C CRC64;
MSAHSMLCER IAIAKELIKR AESLSRSRKG GIEGGAKLCS KLKAELKFLQ KVEAGKVAIK
ESHLQSTNLT HLRAIVESAE NLEEVVSVLH VFGYTDTLGE KQTLVVDVVA NGGHTWVKAI
GRKAEALHNI WLGRGQYGDK SIIEQAEDFL QASHQQPVQY SNPHIIFAFY NSVSSPMAEK
LKEMGISVRG DIVAVNALLD HPEELQPSES ESDDEGPELL QVTRVDRENI LASVAFPTEI
KVDVCKRVNL DITTLITYVS ALSYGGCHFI FKEKVLTEQA EQERKEQVLP QLEAFMKDKE
LFACESAVKD FQSILDTLGG PGERERATVL IKRINVVPDQ PSERALRLVA SSKINSRSLT
IFGTGDTLKA ITMTANSGFV RAANNQGVKF SVFIHQPRAL TESKEALATP LPKDYTTDSE
H
