CG031_HUMAN
ID CG031_HUMAN Reviewed; 590 AA.
AC Q8N865; A4D165; Q6MZV8; Q6P989; Q7LE28; Q86XK1; Q8N1H5; Q96BN4;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 3.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Uncharacterized protein C7orf31;
GN Name=C7orf31;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS THR-158; SER-187 AND
RP ARG-300.
RC TISSUE=Spleen, and Stomach;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANTS THR-158;
RP SER-187 AND ARG-300.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS CYS-82; GLN-143;
RP SER-187; GLN-238; ARG-300 AND ASP-518.
RC TISSUE=Kidney, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 124-590, AND VARIANTS THR-158;
RP SER-187 AND ARG-300.
RC TISSUE=Small intestine;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP SUBCELLULAR LOCATION.
RX PubMed=25074808; DOI=10.1242/jcs.157008;
RA Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT "Proteomic analysis of mammalian sperm cells identifies new components of
RT the centrosome.";
RL J. Cell Sci. 127:4128-4133(2014).
RN [7]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-427 AND LYS-545, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- INTERACTION:
CC Q8N865; Q92870-2: APBB2; NbExp=3; IntAct=EBI-10174456, EBI-21535880;
CC Q8N865; P54252: ATXN3; NbExp=3; IntAct=EBI-10174456, EBI-946046;
CC Q8N865; P41182: BCL6; NbExp=3; IntAct=EBI-10174456, EBI-765407;
CC Q8N865; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-10174456, EBI-11980535;
CC Q8N865; O95833: CLIC3; NbExp=3; IntAct=EBI-10174456, EBI-10192241;
CC Q8N865; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10174456, EBI-3867333;
CC Q8N865; P28799: GRN; NbExp=3; IntAct=EBI-10174456, EBI-747754;
CC Q8N865; O75031: HSF2BP; NbExp=3; IntAct=EBI-10174456, EBI-7116203;
CC Q8N865; P42858: HTT; NbExp=3; IntAct=EBI-10174456, EBI-466029;
CC Q8N865; Q7L273: KCTD9; NbExp=3; IntAct=EBI-10174456, EBI-4397613;
CC Q8N865; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10174456, EBI-10975473;
CC Q8N865; P07196: NEFL; NbExp=3; IntAct=EBI-10174456, EBI-475646;
CC Q8N865; O43482: OIP5; NbExp=3; IntAct=EBI-10174456, EBI-536879;
CC Q8N865; Q99471: PFDN5; NbExp=3; IntAct=EBI-10174456, EBI-357275;
CC Q8N865; O14832: PHYH; NbExp=3; IntAct=EBI-10174456, EBI-721853;
CC Q8N865; P60891: PRPS1; NbExp=3; IntAct=EBI-10174456, EBI-749195;
CC Q8N865; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10174456, EBI-396669;
CC Q8N865; Q96M29: TEKT5; NbExp=3; IntAct=EBI-10174456, EBI-10239812;
CC Q8N865; A8K5H9; NbExp=3; IntAct=EBI-10174456, EBI-10174421;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome {ECO:0000269|PubMed:25074808}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAP22338.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAC05255.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK097248; BAC04985.1; -; mRNA.
DR EMBL; AK098189; BAC05255.1; ALT_INIT; mRNA.
DR EMBL; AC004129; AAP22338.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH236948; EAL24238.1; -; Genomic_DNA.
DR EMBL; CH471073; EAW93827.1; -; Genomic_DNA.
DR EMBL; BC015397; AAH15397.2; -; mRNA.
DR EMBL; BC043269; AAH43269.1; -; mRNA.
DR EMBL; BC060879; AAH60879.1; -; mRNA.
DR EMBL; BX640851; CAE45919.1; -; mRNA.
DR CCDS; CCDS5394.1; -.
DR RefSeq; NP_620166.3; NM_138811.3.
DR RefSeq; XP_005249676.1; XM_005249619.3.
DR RefSeq; XP_005249677.1; XM_005249620.3.
DR RefSeq; XP_011513427.1; XM_011515125.2.
DR AlphaFoldDB; Q8N865; -.
DR BioGRID; 126465; 14.
DR IntAct; Q8N865; 24.
DR STRING; 9606.ENSP00000386604; -.
DR iPTMnet; Q8N865; -.
DR PhosphoSitePlus; Q8N865; -.
DR BioMuta; C7orf31; -.
DR DMDM; 269849700; -.
DR EPD; Q8N865; -.
DR MassIVE; Q8N865; -.
DR PaxDb; Q8N865; -.
DR PeptideAtlas; Q8N865; -.
DR PRIDE; Q8N865; -.
DR ProteomicsDB; 72377; -.
DR Antibodypedia; 12287; 57 antibodies from 19 providers.
DR DNASU; 136895; -.
DR Ensembl; ENST00000283905.8; ENSP00000283905.3; ENSG00000153790.12.
DR Ensembl; ENST00000409280.5; ENSP00000386604.1; ENSG00000153790.12.
DR GeneID; 136895; -.
DR KEGG; hsa:136895; -.
DR MANE-Select; ENST00000283905.8; ENSP00000283905.3; NM_138811.4; NP_620166.3.
DR UCSC; uc003sxn.2; human.
DR CTD; 136895; -.
DR DisGeNET; 136895; -.
DR GeneCards; C7orf31; -.
DR HGNC; HGNC:21722; C7orf31.
DR HPA; ENSG00000153790; Tissue enriched (testis).
DR MIM; 616071; gene.
DR neXtProt; NX_Q8N865; -.
DR OpenTargets; ENSG00000153790; -.
DR PharmGKB; PA134924921; -.
DR VEuPathDB; HostDB:ENSG00000153790; -.
DR eggNOG; ENOG502QUAM; Eukaryota.
DR GeneTree; ENSGT00390000015236; -.
DR HOGENOM; CLU_038659_0_0_1; -.
DR InParanoid; Q8N865; -.
DR OMA; DFPKCVE; -.
DR OrthoDB; 1113879at2759; -.
DR PhylomeDB; Q8N865; -.
DR TreeFam; TF336164; -.
DR PathwayCommons; Q8N865; -.
DR SignaLink; Q8N865; -.
DR BioGRID-ORCS; 136895; 11 hits in 1070 CRISPR screens.
DR ChiTaRS; C7orf31; human.
DR GenomeRNAi; 136895; -.
DR Pharos; Q8N865; Tdark.
DR PRO; PR:Q8N865; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8N865; protein.
DR Bgee; ENSG00000153790; Expressed in sperm and 128 other tissues.
DR ExpressionAtlas; Q8N865; baseline and differential.
DR Genevisible; Q8N865; HS.
DR GO; GO:0005813; C:centrosome; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR InterPro; IPR027886; DUF4555.
DR PANTHER; PTHR31393; PTHR31393; 1.
DR Pfam; PF15093; DUF4555; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Cytoskeleton; Isopeptide bond; Phosphoprotein;
KW Reference proteome; Ubl conjugation.
FT CHAIN 1..590
FT /note="Uncharacterized protein C7orf31"
FT /id="PRO_0000089587"
FT MOD_RES 219
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYM0"
FT MOD_RES 407
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYM0"
FT MOD_RES 422
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYM0"
FT MOD_RES 442
FT /note="Phosphotyrosine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYM0"
FT MOD_RES 485
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYM0"
FT MOD_RES 547
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6AYM0"
FT CROSSLNK 427
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 545
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VARIANT 13
FT /note="E -> K (in dbSNP:rs11980216)"
FT /id="VAR_056809"
FT VARIANT 82
FT /note="Y -> C (in dbSNP:rs2717858)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_022781"
FT VARIANT 86
FT /note="R -> C (in dbSNP:rs3213642)"
FT /id="VAR_056810"
FT VARIANT 143
FT /note="P -> Q (in dbSNP:rs17855102)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060608"
FT VARIANT 158
FT /note="A -> T (in dbSNP:rs12535348)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.3"
FT /id="VAR_022782"
FT VARIANT 187
FT /note="T -> S (in dbSNP:rs2523072)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.3"
FT /id="VAR_022783"
FT VARIANT 238
FT /note="P -> Q (in dbSNP:rs11984293)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_056811"
FT VARIANT 249
FT /note="A -> T (in dbSNP:rs17150982)"
FT /id="VAR_056812"
FT VARIANT 300
FT /note="H -> R (in dbSNP:rs2285738)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:17974005,
FT ECO:0000269|Ref.3"
FT /id="VAR_022784"
FT VARIANT 518
FT /note="N -> D (in dbSNP:rs17857512)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_060609"
SQ SEQUENCE 590 AA; 68464 MW; E2FCDAA48BB8ED8E CRC64;
MEVIHGRPYC CRELEGADIL SNTFYSNELH NPLQTVTRPT ASEDRYQELR ESLQQCRLPW
GAEREYGGII PISLPEDHRP KYEPPRVMGK GHQHYGFGGE TWPRKLPVEQ FYYLTQNKKS
DVYGNDSLIP KPPNSTVGEI CLPYPIEHPY HTHICRGAMF PTFTSPEDLY TGIKARTQQP
FPPTVPTKAY DSTVLKTRGN PYRYELIDIP MDSKKKALTW PGQGVYYDFP RGVEKNKPVF
YPKPPKTFAP NTSLNSWDPI CSAKEANIQR NLERSHWLTS YTHDFTGLGP MDPLELDDYH
EKMVAELTRK IGFDPEPQEK FHPVFKPPRP LEGRIARLIQ NRRSLEAIVQ QRPRSCPDCT
PRVLCNFHTF VPSSKEMVAL SDNIPAGVTH KNQDIEEKII EEQSLLSTYE LPSCYPTKDL
TSIYDIKPFP KITDTKKTED LYWRQQSLKT QPTPYCKPDH WIHYENLKSP LRDQYNMCPD
PVSLSKPSVL QNKQDTEAFT LEHFLSKPEE ELFLNMENNE ETRPVLGWIP RAGVTKPQTN
LLELKNSFSK TGAQKRFHKS ILEDHKDLRD NEHSGMKHQF YGHNSYYFYN
