CG050_HUMAN
ID CG050_HUMAN Reviewed; 194 AA.
AC Q9BRJ6;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Uncharacterized protein C7orf50;
GN Name=C7orf50; ORFNames=FP15621;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15498874; DOI=10.1073/pnas.0404089101;
RA Wan D., Gong Y., Qin W., Zhang P., Li J., Wei L., Zhou X., Li H., Qiu X.,
RA Zhong F., He L., Yu J., Yao G., Jiang H., Qian L., Yu Y., Shu H., Chen X.,
RA Xu H., Guo M., Pan Z., Chen Y., Ge C., Yang S., Gu J.;
RT "Large-scale cDNA transfection screening for genes related to cancer
RT development and progression.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:15724-15729(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-23 AND SER-97, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-97, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-175, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-59 AND SER-175, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q9BRJ6; P28799: GRN; NbExp=3; IntAct=EBI-751612, EBI-747754;
CC Q9BRJ6; P42858: HTT; NbExp=6; IntAct=EBI-751612, EBI-466029;
CC Q9BRJ6; Q9NVV9: THAP1; NbExp=6; IntAct=EBI-751612, EBI-741515;
CC Q9BRJ6; O76024: WFS1; NbExp=3; IntAct=EBI-751612, EBI-720609;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF495721; AAQ06675.1; -; mRNA.
DR EMBL; BC006224; AAH06224.1; -; mRNA.
DR CCDS; CCDS5320.1; -.
DR RefSeq; NP_001127867.1; NM_001134395.1.
DR RefSeq; NP_001127868.1; NM_001134396.1.
DR RefSeq; NP_001305181.1; NM_001318252.1.
DR RefSeq; NP_115726.1; NM_032350.5.
DR AlphaFoldDB; Q9BRJ6; -.
DR BioGRID; 124036; 398.
DR IntAct; Q9BRJ6; 62.
DR MINT; Q9BRJ6; -.
DR STRING; 9606.ENSP00000380286; -.
DR GlyGen; Q9BRJ6; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9BRJ6; -.
DR PhosphoSitePlus; Q9BRJ6; -.
DR SwissPalm; Q9BRJ6; -.
DR BioMuta; C7orf50; -.
DR DMDM; 74732893; -.
DR EPD; Q9BRJ6; -.
DR jPOST; Q9BRJ6; -.
DR MassIVE; Q9BRJ6; -.
DR MaxQB; Q9BRJ6; -.
DR PaxDb; Q9BRJ6; -.
DR PeptideAtlas; Q9BRJ6; -.
DR PRIDE; Q9BRJ6; -.
DR ProteomicsDB; 78770; -.
DR Antibodypedia; 43531; 134 antibodies from 25 providers.
DR DNASU; 84310; -.
DR Ensembl; ENST00000357429.10; ENSP00000350011.5; ENSG00000146540.15.
DR Ensembl; ENST00000397098.8; ENSP00000380286.3; ENSG00000146540.15.
DR Ensembl; ENST00000397100.6; ENSP00000380288.2; ENSG00000146540.15.
DR GeneID; 84310; -.
DR KEGG; hsa:84310; -.
DR MANE-Select; ENST00000397098.8; ENSP00000380286.3; NM_001318252.2; NP_001305181.1.
DR UCSC; uc003sju.3; human.
DR CTD; 84310; -.
DR DisGeNET; 84310; -.
DR GeneCards; C7orf50; -.
DR HGNC; HGNC:22421; C7orf50.
DR HPA; ENSG00000146540; Low tissue specificity.
DR neXtProt; NX_Q9BRJ6; -.
DR OpenTargets; ENSG00000146540; -.
DR PharmGKB; PA162380546; -.
DR VEuPathDB; HostDB:ENSG00000146540; -.
DR eggNOG; KOG4829; Eukaryota.
DR GeneTree; ENSGT00390000017838; -.
DR HOGENOM; CLU_091382_1_0_1; -.
DR InParanoid; Q9BRJ6; -.
DR OMA; SRQEWKF; -.
DR OrthoDB; 1360485at2759; -.
DR PhylomeDB; Q9BRJ6; -.
DR TreeFam; TF326634; -.
DR PathwayCommons; Q9BRJ6; -.
DR SignaLink; Q9BRJ6; -.
DR BioGRID-ORCS; 84310; 143 hits in 1067 CRISPR screens.
DR ChiTaRS; C7orf50; human.
DR GenomeRNAi; 84310; -.
DR Pharos; Q9BRJ6; Tbio.
DR PRO; PR:Q9BRJ6; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q9BRJ6; protein.
DR Bgee; ENSG00000146540; Expressed in adenohypophysis and 171 other tissues.
DR ExpressionAtlas; Q9BRJ6; baseline and differential.
DR Genevisible; Q9BRJ6; HS.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR019327; DUF2373.
DR Pfam; PF10180; WKF; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..194
FT /note="Uncharacterized protein C7orf50"
FT /id="PRO_0000309510"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 23
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 97
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18669648,
FT ECO:0007744|PubMed:20068231"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21406692,
FT ECO:0007744|PubMed:23186163"
SQ SEQUENCE 194 AA; 22083 MW; EDFF8B6A335416F3 CRC64;
MAKQKRKVPE VTEKKNKKLK KASAEGPLLG PEAAPSGEGA GSKGEAVLRP GLDAEPELSP
EEQRVLERKL KKERKKEERQ RLREAGLVAQ HPPARRSGAE LALDYLCRWA QKHKNWRFQK
TRQTWLLLHM YDSDKVPDEH FSTLLAYLEG LQGRARELTV QKAEALMREL DEEGSDPPLP
GRAQRIRQVL QLLS
