CG050_MOUSE
ID CG050_MOUSE Reviewed; 195 AA.
AC Q9CXL3; G5E8F7; Q6PDQ0;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-OCT-2012, sequence version 3.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Uncharacterized protein C7orf50 homolog;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryonic head;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
RA Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
RA Thibault P.;
RT "The phagosomal proteome in interferon-gamma-activated macrophages.";
RL Immunity 30:143-154(2009).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-48 AND SER-52, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB29235.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK014271; BAB29235.1; ALT_FRAME; mRNA.
DR EMBL; AC140216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC161058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466529; EDL19152.1; -; Genomic_DNA.
DR CCDS; CCDS51684.1; -.
DR RefSeq; NP_082745.2; NM_028469.3.
DR AlphaFoldDB; Q9CXL3; -.
DR BioGRID; 215841; 32.
DR IntAct; Q9CXL3; 1.
DR MINT; Q9CXL3; -.
DR STRING; 10090.ENSMUSP00000069230; -.
DR iPTMnet; Q9CXL3; -.
DR PhosphoSitePlus; Q9CXL3; -.
DR EPD; Q9CXL3; -.
DR jPOST; Q9CXL3; -.
DR MaxQB; Q9CXL3; -.
DR PaxDb; Q9CXL3; -.
DR PeptideAtlas; Q9CXL3; -.
DR PRIDE; Q9CXL3; -.
DR Antibodypedia; 43531; 134 antibodies from 25 providers.
DR Ensembl; ENSMUST00000066052; ENSMUSP00000069230; ENSMUSG00000053553.
DR GeneID; 73212; -.
DR KEGG; mmu:73212; -.
DR UCSC; uc009agk.1; mouse.
DR MGI; MGI:1920462; 3110082I17Rik.
DR VEuPathDB; HostDB:ENSMUSG00000053553; -.
DR eggNOG; KOG4829; Eukaryota.
DR GeneTree; ENSGT00390000017838; -.
DR HOGENOM; CLU_091382_2_0_1; -.
DR InParanoid; Q9CXL3; -.
DR OMA; WAKKHEN; -.
DR OrthoDB; 1500440at2759; -.
DR PhylomeDB; Q9CXL3; -.
DR TreeFam; TF326634; -.
DR BioGRID-ORCS; 73212; 5 hits in 71 CRISPR screens.
DR PRO; PR:Q9CXL3; -.
DR Proteomes; UP000000589; Chromosome 5.
DR RNAct; Q9CXL3; protein.
DR Bgee; ENSMUSG00000053553; Expressed in yolk sac and 173 other tissues.
DR ExpressionAtlas; Q9CXL3; baseline and differential.
DR Genevisible; Q9CXL3; MM.
DR InterPro; IPR019327; DUF2373.
DR Pfam; PF10180; WKF; 1.
PE 1: Evidence at protein level;
KW Phosphoprotein; Reference proteome.
FT CHAIN 1..195
FT /note="Uncharacterized protein C7orf50 homolog"
FT /id="PRO_0000309511"
FT REGION 1..78
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..78
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 41
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5I0E3"
FT MOD_RES 48
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19144319,
FT ECO:0007744|PubMed:21183079"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 96
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9BRJ6"
FT CONFLICT 28
FT /note="P -> R (in Ref. 1; BAB29235)"
FT /evidence="ECO:0000305"
FT CONFLICT 181
FT /note="P -> R (in Ref. 1; BAB29235)"
FT /evidence="ECO:0000305"
FT CONFLICT 188
FT /note="R -> H (in Ref. 1; BAB29235)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 195 AA; 22168 MW; 04CCCB17F8EBB73D CRC64;
MAKHKRKGLE GTGKESKRQK ITPAEETPRT SEAGPDKETA STLVQEASPE LSPEERRVLE
RKLKKERKKE EKKRLREAGI AATQTAKVQT LPAKPSAATL ALEYLQGWAQ KQESWRFQKT
RQTWLLLHMY DEDKVPDEHF PTLLDYLEGL RGSARELTVR KAEALMQKLD EAEPEDSGGS
PGKVQRLRQV LQLLS
