CG057_HUMAN
ID CG057_HUMAN Reviewed; 295 AA.
AC Q8NEG2; C9JBJ8;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Uncharacterized protein C7orf57;
GN Name=C7orf57;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NEG2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NEG2-2; Sequence=VSP_046991, VSP_046992, VSP_046993;
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DR EMBL; AC069279; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC031107; AAH31107.1; -; mRNA.
DR CCDS; CCDS47583.1; -. [Q8NEG2-1]
DR CCDS; CCDS59054.1; -. [Q8NEG2-2]
DR RefSeq; NP_001093629.1; NM_001100159.2. [Q8NEG2-1]
DR RefSeq; XP_011513423.1; XM_011515121.1. [Q8NEG2-1]
DR AlphaFoldDB; Q8NEG2; -.
DR BioGRID; 126452; 9.
DR STRING; 9606.ENSP00000335500; -.
DR iPTMnet; Q8NEG2; -.
DR PhosphoSitePlus; Q8NEG2; -.
DR BioMuta; C7orf57; -.
DR DMDM; 296439408; -.
DR MassIVE; Q8NEG2; -.
DR PaxDb; Q8NEG2; -.
DR PeptideAtlas; Q8NEG2; -.
DR PRIDE; Q8NEG2; -.
DR ProteomicsDB; 73161; -. [Q8NEG2-1]
DR ProteomicsDB; 9475; -.
DR Antibodypedia; 7300; 64 antibodies from 14 providers.
DR DNASU; 136288; -.
DR Ensembl; ENST00000348904.4; ENSP00000335500.3; ENSG00000164746.14. [Q8NEG2-1]
DR Ensembl; ENST00000435376.5; ENSP00000391652.1; ENSG00000164746.14. [Q8NEG2-2]
DR GeneID; 136288; -.
DR KEGG; hsa:136288; -.
DR MANE-Select; ENST00000348904.4; ENSP00000335500.3; NM_001100159.3; NP_001093629.1.
DR UCSC; uc003toh.6; human. [Q8NEG2-1]
DR CTD; 136288; -.
DR GeneCards; C7orf57; -.
DR HGNC; HGNC:22247; C7orf57.
DR HPA; ENSG00000164746; Tissue enhanced (choroid plexus, fallopian tube).
DR neXtProt; NX_Q8NEG2; -.
DR OpenTargets; ENSG00000164746; -.
DR PharmGKB; PA162380613; -.
DR VEuPathDB; HostDB:ENSG00000164746; -.
DR eggNOG; ENOG502S6DP; Eukaryota.
DR GeneTree; ENSGT00390000014376; -.
DR HOGENOM; CLU_123119_0_0_1; -.
DR InParanoid; Q8NEG2; -.
DR OMA; MVYEEFH; -.
DR PhylomeDB; Q8NEG2; -.
DR TreeFam; TF330795; -.
DR PathwayCommons; Q8NEG2; -.
DR BioGRID-ORCS; 136288; 7 hits in 1054 CRISPR screens.
DR ChiTaRS; C7orf57; human.
DR GenomeRNAi; 136288; -.
DR Pharos; Q8NEG2; Tdark.
DR PRO; PR:Q8NEG2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8NEG2; protein.
DR Bgee; ENSG00000164746; Expressed in bronchial epithelial cell and 80 other tissues.
DR ExpressionAtlas; Q8NEG2; baseline and differential.
DR Genevisible; Q8NEG2; HS.
DR InterPro; IPR040247; DUF5524.
DR PANTHER; PTHR31097; PTHR31097; 1.
DR Pfam; PF17662; DUF5524; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..295
FT /note="Uncharacterized protein C7orf57"
FT /id="PRO_0000310991"
FT REGION 33..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 180..295
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..295
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5SS90"
FT VAR_SEQ 1..122
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046991"
FT VAR_SEQ 203..218
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046992"
FT VAR_SEQ 277..281
FT /note="ESSQS -> G (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046993"
FT VARIANT 74
FT /note="A -> S (in dbSNP:rs10951942)"
FT /id="VAR_056813"
FT CONFLICT 124
FT /note="P -> L (in Ref. 2; AAH31107)"
FT /evidence="ECO:0000305"
FT CONFLICT 152
FT /note="M -> T (in Ref. 2; AAH31107)"
FT /evidence="ECO:0000305"
FT CONFLICT 201
FT /note="P -> H (in Ref. 2; AAH31107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 295 AA; 32846 MW; 6AFA535F4E3AFD30 CRC64;
MRNTSKELQG ATHRYAPCDW YYHVPVKRSE KAVDAPPASQ IPGLSNLGDS HSENLPGTRR
YWIKETDSEY VKLAKQGGRP DLLKHFAPGT RKGSPVAYSL PDWYIHHSKP PTASQQEVRA
VSMPDYMVHE EFNPDQANGS YASRRGPFDF DMKTVWQREA EELEKEKKKL RLPAIDSKYL
SKAGTPLGPK NPAGSRLSFP PVPGQKNSSP TNFSKLISNG YKDEWLQQQQ RADSDKRTPK
TSRASVLSQS PRDLEGPQDA ARLQDAEASE GPEDTPESSQ SPEESVSAST PAELK
