CG121_ASPFU
ID CG121_ASPFU Reviewed; 189 AA.
AC Q4WI37;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=EKC/KEOPS complex subunit cgi121;
GN Name=cgi121; ORFNames=AFUA_2G03210;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as
CC an allosteric effector that regulates the t(6)A activity of the
CC complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC and telomere elongation. The complex is required for efficient
CC recruitment of transcriptional coactivators. Cgi121 is not required for
CC tRNA modification (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least bud32,
CC cgi121, gon7, kae1 and pcc1; the whole complex dimerizes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CGI121/TPRKB family. {ECO:0000305}.
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DR EMBL; AAHF01000008; EAL87418.1; -; Genomic_DNA.
DR RefSeq; XP_749456.1; XM_744363.1.
DR AlphaFoldDB; Q4WI37; -.
DR SMR; Q4WI37; -.
DR STRING; 746128.CADAFUBP00001981; -.
DR EnsemblFungi; EAL87418; EAL87418; AFUA_2G03210.
DR GeneID; 3506708; -.
DR KEGG; afm:AFUA_2G03210; -.
DR VEuPathDB; FungiDB:Afu2g03210; -.
DR eggNOG; KOG4066; Eukaryota.
DR HOGENOM; CLU_065847_1_0_1; -.
DR InParanoid; Q4WI37; -.
DR OMA; HNVHSEI; -.
DR OrthoDB; 1360669at2759; -.
DR Proteomes; UP000002530; Chromosome 2.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000408; C:EKC/KEOPS complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:EnsemblFungi.
DR GO; GO:0000722; P:telomere maintenance via recombination; IBA:GO_Central.
DR GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IBA:GO_Central.
DR Gene3D; 3.30.2380.10; -; 1.
DR InterPro; IPR013926; CGI121/TPRKB.
DR InterPro; IPR036504; CGI121/TPRKB_sf.
DR PANTHER; PTHR15840; PTHR15840; 1.
DR Pfam; PF08617; CGI-121; 1.
DR SUPFAM; SSF143870; SSF143870; 1.
PE 3: Inferred from homology;
KW Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW Transcription; Transcription regulation; tRNA processing.
FT CHAIN 1..189
FT /note="EKC/KEOPS complex subunit cgi121"
FT /id="PRO_0000279206"
SQ SEQUENCE 189 AA; 20841 MW; 304F5F0EC30EC081 CRC64;
MTLPLETIRL PHLPSALPVH IALYRDVNNS PFLRQQLLSG NADFEYAFID ASMVFSRSHI
LSAIFRAVND HLNGRLKSRN VHSEIVFSLS PANNIADSFR KFGITDSTTD LLVVKVSVTP
DVTHASVATH LQQYIEGSPV PFADETLSEI SDISKIKKAY KLGTLGSRDD EKRRLELSLI
GAIALRGAT