CG121_PHANO
ID CG121_PHANO Reviewed; 233 AA.
AC Q0UEM3;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 08-APR-2008, sequence version 2.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=EKC/KEOPS complex subunit CGI121;
GN Name=CGI121; ORFNames=SNOG_09791;
OS Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume
OS blotch fungus) (Parastagonospora nodorum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Pleosporomycetidae; Pleosporales; Pleosporineae; Phaeosphaeriaceae;
OC Parastagonospora.
OX NCBI_TaxID=321614;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SN15 / ATCC MYA-4574 / FGSC 10173;
RX PubMed=18024570; DOI=10.1105/tpc.107.052829;
RA Hane J.K., Lowe R.G.T., Solomon P.S., Tan K.-C., Schoch C.L.,
RA Spatafora J.W., Crous P.W., Kodira C.D., Birren B.W., Galagan J.E.,
RA Torriani S.F.F., McDonald B.A., Oliver R.P.;
RT "Dothideomycete-plant interactions illuminated by genome sequencing and EST
RT analysis of the wheat pathogen Stagonospora nodorum.";
RL Plant Cell 19:3347-3368(2007).
CC -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC formation of a threonylcarbamoyl group on adenosine at position 37
CC (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC is probably involved in the transfer of the threonylcarbamoyl moiety of
CC threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as
CC an allosteric effector that regulates the t(6)A activity of the
CC complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC and telomere elongation. The complex is required for efficient
CC recruitment of transcriptional coactivators. CGI121 is not required for
CC tRNA modification (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least BUD32,
CC CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CGI121/TPRKB family. {ECO:0000305}.
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DR EMBL; CH445339; EAT83056.2; -; Genomic_DNA.
DR RefSeq; XP_001800078.1; XM_001800026.1.
DR AlphaFoldDB; Q0UEM3; -.
DR SMR; Q0UEM3; -.
DR STRING; 13684.SNOT_09791; -.
DR GeneID; 5976983; -.
DR KEGG; pno:SNOG_09791; -.
DR eggNOG; KOG4066; Eukaryota.
DR InParanoid; Q0UEM3; -.
DR OrthoDB; 1360669at2759; -.
DR Proteomes; UP000001055; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0000408; C:EKC/KEOPS complex; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000722; P:telomere maintenance via recombination; IBA:GO_Central.
DR GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IBA:GO_Central.
DR Gene3D; 3.30.2380.10; -; 1.
DR InterPro; IPR013926; CGI121/TPRKB.
DR InterPro; IPR036504; CGI121/TPRKB_sf.
DR PANTHER; PTHR15840; PTHR15840; 1.
DR Pfam; PF08617; CGI-121; 1.
DR SUPFAM; SSF143870; SSF143870; 1.
PE 3: Inferred from homology;
KW Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW Transcription; Transcription regulation; tRNA processing.
FT CHAIN 1..233
FT /note="EKC/KEOPS complex subunit CGI121"
FT /id="PRO_0000279216"
FT REGION 196..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 233 AA; 25652 MW; D3685874A035D0A3 CRC64;
MAHVRTFTLP HYEAYPVHVA LFKDVKNPSY LKSQLLEANP AFDYAFLDAA MVARLGIAWW
SHAAANDRPQ ILSPTHLLST TFITIHALCT HRQKTRTPHS ELVFRLSPNN NIGESYKKFG
ISDTTTHLIA VKLPLKSSDA EAKEWLVDGE ITNESVSQHL GSVVEGTSVE ISEKGEELGQ
WCDIDKIRKV YKLGDGSAKK GKKGAAVNGD GAEKEGEKKQ MEVVILGTIA LKS
