ID   CG121_SCHPO             Reviewed;         174 AA.
AC   Q9P7J3;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 106.
DE   RecName: Full=EKC/KEOPS complex subunit cgi121;
GN   Name=cgi121; ORFNames=SPCC24B10.12;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- FUNCTION: Component of the EKC/KEOPS complex that is required for the
CC       formation of a threonylcarbamoyl group on adenosine at position 37
CC       (t(6)A37) in tRNAs that read codons beginning with adenine. The complex
CC       is probably involved in the transfer of the threonylcarbamoyl moiety of
CC       threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Cgi121 acts as
CC       an allosteric effector that regulates the t(6)A activity of the
CC       complex. The EKC/KEOPS complex also promotes both telomere uncapping
CC       and telomere elongation. The complex is required for efficient
CC       recruitment of transcriptional coactivators. Cgi121 is not required for
CC       tRNA modification (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the EKC/KEOPS complex composed of at least of
CC       SPAP27G11.07c/BUD32, cgi121, gon7, pgp2 and SPAC4H3.13/PCC1; the whole
CC       complex dimerizes. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Chromosome, telomere
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CGI121/TPRKB family. {ECO:0000305}.
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DR   EMBL; CU329672; CAB76221.1; -; Genomic_DNA.
DR   PIR; T50419; T50419.
DR   RefSeq; NP_588015.1; NM_001023006.2.
DR   AlphaFoldDB; Q9P7J3; -.
DR   SMR; Q9P7J3; -.
DR   BioGRID; 275953; 80.
DR   STRING; 4896.SPCC24B10.12.1; -.
DR   MaxQB; Q9P7J3; -.
DR   PaxDb; Q9P7J3; -.
DR   EnsemblFungi; SPCC24B10.12.1; SPCC24B10.12.1:pep; SPCC24B10.12.
DR   GeneID; 2539388; -.
DR   KEGG; spo:SPCC24B10.12; -.
DR   PomBase; SPCC24B10.12; cgi121.
DR   VEuPathDB; FungiDB:SPCC24B10.12; -.
DR   eggNOG; KOG4066; Eukaryota.
DR   HOGENOM; CLU_065847_1_1_1; -.
DR   InParanoid; Q9P7J3; -.
DR   OMA; HNVHSEI; -.
DR   PhylomeDB; Q9P7J3; -.
DR   PRO; PR:Q9P7J3; -.
DR   Proteomes; UP000002485; Chromosome III.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0000408; C:EKC/KEOPS complex; ISO:PomBase.
DR   GO; GO:0005634; C:nucleus; HDA:PomBase.
DR   GO; GO:0000722; P:telomere maintenance via recombination; IBA:GO_Central.
DR   GO; GO:0002949; P:tRNA threonylcarbamoyladenosine modification; IBA:GO_Central.
DR   Gene3D; 3.30.2380.10; -; 1.
DR   InterPro; IPR013926; CGI121/TPRKB.
DR   InterPro; IPR036504; CGI121/TPRKB_sf.
DR   PANTHER; PTHR15840; PTHR15840; 1.
DR   Pfam; PF08617; CGI-121; 1.
DR   SUPFAM; SSF143870; SSF143870; 1.
PE   3: Inferred from homology;
KW   Activator; Chromosome; Nucleus; Reference proteome; Telomere;
KW   Transcription; Transcription regulation; tRNA processing.
FT   CHAIN           1..174
FT                   /note="EKC/KEOPS complex subunit cgi121"
FT                   /id="PRO_0000279217"
SQ   SEQUENCE   174 AA;  20050 MW;  3D4F7FF78A3527C0 CRC64;
     MILPLFPETQ VHVFVYENVS NCAAIHEQLI SQNPIYDYAF LDAATILYKK QVYSAIIRAL
     EDRRDEQMKT KTIHSEVILS LSPKTEISSA FRQFSMTKKS KNIVVVKIDS KLTEEEEFER
     LDKLVEGNRV EFSDEELQKL IDFKVLKKNY KLDPSTLENP LASILSSIAL RGYS