CG13_CANAL
ID CG13_CANAL Reviewed; 465 AA.
AC Q5A1N6; A0A1D8PN43;
DT 13-NOV-2013, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=G1/S-specific cyclin CLN3;
GN Name=CLN3; Synonyms=CLN2; OrderedLocusNames=CAALFM_C501100CA;
GN ORFNames=CaO19.1960, CaO19.9515;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
RN [4]
RP IDENTIFICATION.
RX PubMed=7830719; DOI=10.1007/bf00297278;
RA Sherlock G., Bahman A.M., Mahal A., Shieh J.C., Ferreira M., Rosamond J.;
RT "Molecular cloning and analysis of CDC28 and cyclin homologues from the
RT human fungal pathogen Candida albicans.";
RL Mol. Gen. Genet. 245:716-723(1994).
RN [5]
RP FUNCTION.
RX PubMed=15643064; DOI=10.1128/ec.4.1.90-94.2005;
RA Chapa y Lazo B., Bates S., Sudbery P.;
RT "The G1 cyclin Cln3 regulates morphogenesis in Candida albicans.";
RL Eukaryot. Cell 4:90-94(2005).
RN [6]
RP FUNCTION.
RX PubMed=15643065; DOI=10.1128/ec.4.1.95-102.2005;
RA Bachewich C., Whiteway M.;
RT "Cyclin Cln3p links G1 progression to hyphal and pseudohyphal development
RT in Candida albicans.";
RL Eukaryot. Cell 4:95-102(2005).
RN [7]
RP INDUCTION.
RX PubMed=16002646; DOI=10.1128/ec.4.7.1203-1210.2005;
RA Enjalbert B., Whiteway M.;
RT "Release from quorum-sensing molecules triggers hyphal formation during
RT Candida albicans resumption of growth.";
RL Eukaryot. Cell 4:1203-1210(2005).
RN [8]
RP HYPERPHOSPHORYLATION, GRR1-MEDIATED DEGRADATION, AND FUNCTION.
RX PubMed=16987179; DOI=10.1111/j.1365-2958.2006.05361.x;
RA Li W.J., Wang Y.M., Zheng X.D., Shi Q.M., Zhang T.T., Bai C., Li D.,
RA Sang J.L., Wang Y.;
RT "The F-box protein Grr1 regulates the stability of Ccn1, Cln3 and Hof1 and
RT cell morphogenesis in Candida albicans.";
RL Mol. Microbiol. 62:212-226(2006).
RN [9]
RP INTERACTION WITH CDC28.
RX PubMed=17765684; DOI=10.1016/j.devcel.2007.06.011;
RA Sinha I., Wang Y.M., Philp R., Li C.R., Yap W.H., Wang Y.;
RT "Cyclin-dependent kinases control septin phosphorylation in Candida
RT albicans hyphal development.";
RL Dev. Cell 13:421-432(2007).
RN [10]
RP INTERACTION WITH CDC28 AND SLA1, AND FUNCTION.
RX PubMed=22787279; DOI=10.1091/mbc.e12-03-0231;
RA Zeng G., Wang Y.M., Wang Y.;
RT "Cdc28-Cln3 phosphorylation of Sla1 regulates actin patch dynamics in
RT different modes of fungal growth.";
RL Mol. Biol. Cell 23:3485-3497(2012).
CC -!- FUNCTION: G1/S-specific cyclin essential for the control of the cell
CC cycle at the G1/S (start) transition. CLN3 may be an upstream activator
CC of the G1 cyclins which directly catalyze start. Required for budding
CC and for cell cycle progression and morphogenesis in environment-induced
CC hyphae. Degradation is mediated by GRR1. Through binding to CDC28,
CC controls the phosphorylation of SLA1 which regulates cortical actin
CC patch dynamics. {ECO:0000269|PubMed:15643064,
CC ECO:0000269|PubMed:15643065, ECO:0000269|PubMed:16987179,
CC ECO:0000269|PubMed:22787279}.
CC -!- SUBUNIT: Interacts with CDC28 and SLA1. {ECO:0000269|PubMed:17765684,
CC ECO:0000269|PubMed:22787279}.
CC -!- INDUCTION: Repressed by farnesol. {ECO:0000269|PubMed:16002646}.
CC -!- PTM: Hyperphosphorylated. GRR1 preferentially mediates the degradation
CC of hyperphosphorylated CLN3.
CC -!- SIMILARITY: Belongs to the cyclin family. {ECO:0000305}.
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DR EMBL; CP017627; AOW29548.1; -; Genomic_DNA.
DR RefSeq; XP_715723.1; XM_710630.2.
DR AlphaFoldDB; Q5A1N6; -.
DR SMR; Q5A1N6; -.
DR BioGRID; 1225718; 2.
DR STRING; 237561.Q5A1N6; -.
DR PRIDE; Q5A1N6; -.
DR GeneID; 3642624; -.
DR KEGG; cal:CAALFM_C501100CA; -.
DR CGD; CAL0000185532; CLN3.
DR VEuPathDB; FungiDB:C5_01100C_A; -.
DR eggNOG; KOG0653; Eukaryota.
DR HOGENOM; CLU_033561_0_0_1; -.
DR InParanoid; Q5A1N6; -.
DR OrthoDB; 993640at2759; -.
DR PRO; PR:Q5A1N6; -.
DR Proteomes; UP000000559; Chromosome 5.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IGI:CGD.
DR GO; GO:0007114; P:cell budding; IMP:CGD.
DR GO; GO:0030447; P:filamentous growth; IMP:CGD.
DR GO; GO:0044182; P:filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0000082; P:G1/S transition of mitotic cell cycle; IEP:CGD.
DR GO; GO:0030448; P:hyphal growth; IMP:CGD.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:1900429; P:negative regulation of filamentous growth of a population of unicellular organisms; IMP:CGD.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:CGD.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IGI:CGD.
DR GO; GO:2000045; P:regulation of G1/S transition of mitotic cell cycle; IEA:InterPro.
DR CDD; cd00043; CYCLIN; 1.
DR InterPro; IPR028857; CCNF_metazoan.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR014399; Cyclin_CLN.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR PANTHER; PTHR10177:SF252; PTHR10177:SF252; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001770; Cyclin_CLN; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SUPFAM; SSF47954; SSF47954; 1.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Mitosis; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..465
FT /note="G1/S-specific cyclin CLN3"
FT /id="PRO_0000424364"
FT DOMAIN 44..171
FT /note="Cyclin N-terminal"
SQ SEQUENCE 465 AA; 53177 MW; 38C0CFA0D3F3EDCF CRC64;
MFPNSPDAFH QVRMMQSSIK ASNFKLQSME FRCHSNNVCE YQMEMLHHLL SVEAKTLPNL
SLIEQQPEIK LGMRPLLLDF LMEVITILSL SRSTFPLTVN LIDRYCSTRI VKKQHYQLLG
LTSLWISCKN LDSKFKVPTL NDLRKICVDS YYKELFVEME KHILKSLEWV VNAPTFDAFI
DLYSNLLISN SSNFEVANII KKSSHKIKLF SNYIGELFQF YPNIYYDYTS SQIALIAILI
TVLTLKIPVD LISLLNFYNG LVKTEMFKSN VEQGAEDQFE EILSVDSFKS LFNKSFFKNL
IKIIDNPPSS LKIKYFAENG KYSVLMKQLV TTASNTLKCI LDPVPTTPKA NSFVKHQQQQ
HHYHPRPPMS INTSMIPLTP VSNSTSPNRF SPDQIFSENE STPGIAFGTM TPDSQSTSPG
EKRSYECIDE LEIGTSTIAG YTLKNHDTLK RSKSANYGTL FYLQQ
