CG23_YEAST
ID CG23_YEAST Reviewed; 427 AA.
AC P24870; D6VRJ5;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 25-OCT-2004, sequence version 3.
DT 03-AUG-2022, entry version 192.
DE RecName: Full=G2/mitotic-specific cyclin-3;
GN Name=CLB3; OrderedLocusNames=YDL155W; ORFNames=D1539;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1427070; DOI=10.1101/gad.6.11.2021;
RA Richardson H., Lew D.J., Henze M., Sugimoto K., Reed S.I.;
RT "Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in
RT G2.";
RL Genes Dev. 6:2021-2034(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1387566; DOI=10.1091/mbc.3.7.805;
RA Fitch I., Dahmann C., Surana U., Amon A., Nasmyth K., Goetsch L., Byers B.,
RA Futcher B.;
RT "Characterization of four B-type cyclin genes of the budding yeast
RT Saccharomyces cerevisiae.";
RL Mol. Biol. Cell 3:805-818(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 96604 / S288c / FY1679;
RX PubMed=8972581;
RX DOI=10.1002/(sici)1097-0061(199612)12:15%3c1587::aid-yea46%3e3.0.co;2-6;
RA Delaveau T.T.D., Blugeon C., Jacq C., Perea J.;
RT "Analysis of a 23 kb region on the left arm of yeast chromosome IV.";
RL Yeast 12:1587-1592(1996).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169867;
RA Jacq C., Alt-Moerbe J., Andre B., Arnold W., Bahr A., Ballesta J.P.G.,
RA Bargues M., Baron L., Becker A., Biteau N., Bloecker H., Blugeon C.,
RA Boskovic J., Brandt P., Brueckner M., Buitrago M.J., Coster F.,
RA Delaveau T., del Rey F., Dujon B., Eide L.G., Garcia-Cantalejo J.M.,
RA Goffeau A., Gomez-Peris A., Granotier C., Hanemann V., Hankeln T.,
RA Hoheisel J.D., Jaeger W., Jimenez A., Jonniaux J.-L., Kraemer C.,
RA Kuester H., Laamanen P., Legros Y., Louis E.J., Moeller-Rieker S.,
RA Monnet A., Moro M., Mueller-Auer S., Nussbaumer B., Paricio N., Paulin L.,
RA Perea J., Perez-Alonso M., Perez-Ortin J.E., Pohl T.M., Prydz H.,
RA Purnelle B., Rasmussen S.W., Remacha M.A., Revuelta J.L., Rieger M.,
RA Salom D., Saluz H.P., Saiz J.E., Saren A.-M., Schaefer M., Scharfe M.,
RA Schmidt E.R., Schneider C., Scholler P., Schwarz S., Soler-Mira A.,
RA Urrestarazu L.A., Verhasselt P., Vissers S., Voet M., Volckaert G.,
RA Wagner G., Wambutt R., Wedler E., Wedler H., Woelfl S., Harris D.E.,
RA Bowman S., Brown D., Churcher C.M., Connor R., Dedman K., Gentles S.,
RA Hamlin N., Hunt S., Jones L., McDonald S., Murphy L.D., Niblett D.,
RA Odell C., Oliver K., Rajandream M.A., Richards C., Shore L., Walsh S.V.,
RA Barrell B.G., Dietrich F.S., Mulligan J.T., Allen E., Araujo R., Aviles E.,
RA Berno A., Carpenter J., Chen E., Cherry J.M., Chung E., Duncan M.,
RA Hunicke-Smith S., Hyman R.W., Komp C., Lashkari D., Lew H., Lin D.,
RA Mosedale D., Nakahara K., Namath A., Oefner P., Oh C., Petel F.X.,
RA Roberts D., Schramm S., Schroeder M., Shogren T., Shroff N., Winant A.,
RA Yelton M.A., Botstein D., Davis R.W., Johnston M., Andrews S., Brinkman R.,
RA Cooper J., Ding H., Du Z., Favello A., Fulton L., Gattung S., Greco T.,
RA Hallsworth K., Hawkins J., Hillier L.W., Jier M., Johnson D., Johnston L.,
RA Kirsten J., Kucaba T., Langston Y., Latreille P., Le T., Mardis E.,
RA Menezes S., Miller N., Nhan M., Pauley A., Peluso D., Rifkin L., Riles L.,
RA Taich A., Trevaskis E., Vignati D., Wilcox L., Wohldman P., Vaudin M.,
RA Wilson R., Waterston R., Albermann K., Hani J., Heumann K., Kleine K.,
RA Mewes H.-W., Zollner A., Zaccaria P.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IV.";
RL Nature 387:75-78(1997).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=17322287; DOI=10.1101/gr.6037607;
RA Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F.,
RA Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J.,
RA Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J.,
RA Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D.,
RA LaBaer J.;
RT "Approaching a complete repository of sequence-verified protein-encoding
RT clones for Saccharomyces cerevisiae.";
RL Genome Res. 17:536-543(2007).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 194-383.
RX PubMed=1849457; DOI=10.1016/0092-8674(91)90416-v;
RA Surana U., Robitsch H., Price C., Schuster T., Fitch I., Futcher A.B.,
RA Nasmyth K.;
RT "The role of CDC28 and cyclins during mitosis in the budding yeast S.
RT cerevisiae.";
RL Cell 65:145-161(1991).
RN [8]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC (mitosis) transition. Interacts with the CDC2 protein kinase to form
CC MPF. G2/M cyclins accumulate steadily during G2 and are abruptly
CC destroyed at mitosis.
CC -!- INTERACTION:
CC P24870; Q00684: CDC14; NbExp=2; IntAct=EBI-4522, EBI-4192;
CC P24870; P20486: CKS1; NbExp=4; IntAct=EBI-4522, EBI-4746;
CC -!- MISCELLANEOUS: Present with 892 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
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DR EMBL; X69425; CAA49201.1; -; Genomic_DNA.
DR EMBL; M80302; AAA34765.1; -; Genomic_DNA.
DR EMBL; X97751; CAA66336.1; -; Genomic_DNA.
DR EMBL; Z74203; CAA98729.1; -; Genomic_DNA.
DR EMBL; AY692856; AAT92875.1; -; Genomic_DNA.
DR EMBL; BK006938; DAA11705.1; -; Genomic_DNA.
DR PIR; A60048; A60048.
DR RefSeq; NP_010126.1; NM_001180215.1.
DR AlphaFoldDB; P24870; -.
DR SMR; P24870; -.
DR BioGRID; 31908; 163.
DR ComplexPortal; CPX-336; CLB3-CDC28 kinase complex.
DR DIP; DIP-1266N; -.
DR IntAct; P24870; 32.
DR MINT; P24870; -.
DR STRING; 4932.YDL155W; -.
DR iPTMnet; P24870; -.
DR PaxDb; P24870; -.
DR PRIDE; P24870; -.
DR EnsemblFungi; YDL155W_mRNA; YDL155W; YDL155W.
DR GeneID; 851400; -.
DR KEGG; sce:YDL155W; -.
DR SGD; S000002314; CLB3.
DR VEuPathDB; FungiDB:YDL155W; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000168350; -.
DR HOGENOM; CLU_020695_12_1_1; -.
DR InParanoid; P24870; -.
DR OMA; NPRYMDF; -.
DR BioCyc; YEAST:G3O-29550-MON; -.
DR PRO; PR:P24870; -.
DR Proteomes; UP000002311; Chromosome IV.
DR RNAct; P24870; protein.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IMP:SGD.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD.
DR GO; GO:0007135; P:meiosis II; IDA:SGD.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0010696; P:positive regulation of mitotic spindle pole body separation; IGI:SGD.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IMP:SGD.
DR GO; GO:1901673; P:regulation of mitotic spindle assembly; IGI:SGD.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Mitosis; Reference proteome.
FT CHAIN 1..427
FT /note="G2/mitotic-specific cyclin-3"
FT /id="PRO_0000080405"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 89..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..105
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 106..126
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 48
FT /note="D -> R (in Ref. 1; CAA49201)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 427 AA; 49476 MW; 91EE26655A5EC72D CRC64;
MHHNSQSLSS GHIRSPEDEN VAPIGNLKHR TGSLSHISSA HPRVALSDVT NIVATNSSNN
SISKPKVAPI KERLDSAAII EEERLDANSV AQRKEADHND LLTDREQEEP VEDDGESEED
EEEDQEPLLL QHYASDTLVW EHAFRTYYRT TLDPNDDDVY DVVMVAELSN EIFEYMRKLE
DLYKPNPYYM DKQPELRWSF RSTLIDWIVQ VHEKFQLLPE TLYLCINIID RYLCKEVVPV
NKFQLVGAAS LFIAAKYEEI NCPTIKDFVY MSENCYSRND LLDAERTILN GLEFELGWPG
PMSFLRRISK ADDYEHDTRT LAKYLLESTI MDHRLVSAQP SWLAAGAYFL SKIILGQNQW
SLAHVYYSNY TQEQILPLAT IILENCRYAS KRHNAIWRKY SSRRYLHSSQ IVAKWIALAE
HRVERSN
