CG24_YEAST
ID CG24_YEAST Reviewed; 460 AA.
AC P24871; D6VYL1;
DT 01-MAR-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 2.
DT 03-AUG-2022, entry version 176.
DE RecName: Full=G2/mitotic-specific cyclin-4;
GN Name=CLB4; OrderedLocusNames=YLR210W; ORFNames=L8167.3;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=1427070; DOI=10.1101/gad.6.11.2021;
RA Richardson H., Lew D.J., Henze M., Sugimoto K., Reed S.I.;
RT "Cyclin-B homologs in Saccharomyces cerevisiae function in S phase and in
RT G2.";
RL Genes Dev. 6:2021-2034(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1387566; DOI=10.1091/mbc.3.7.805;
RA Fitch I., Dahmann C., Surana U., Amon A., Nasmyth K., Goetsch L., Byers B.,
RA Futcher B.;
RT "Characterization of four B-type cyclin genes of the budding yeast
RT Saccharomyces cerevisiae.";
RL Mol. Biol. Cell 3:805-818(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169871;
RA Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W.,
RA Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A.,
RA Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K.,
RA Heuss-Neitzel D., Hilbert H., Hilger F., Kleine K., Koetter P., Louis E.J.,
RA Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S.,
RA Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D.,
RA Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M.,
RA Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P.,
RA Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M.,
RA Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K.,
RA Zollner A., Hani J., Hoheisel J.D.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII.";
RL Nature 387:87-90(1997).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 233-422.
RX PubMed=1849457; DOI=10.1016/0092-8674(91)90416-v;
RA Surana U., Robitsch H., Price C., Schuster T., Fitch I., Futcher A.B.,
RA Nasmyth K.;
RT "The role of CDC28 and cyclins during mitosis in the budding yeast S.
RT cerevisiae.";
RL Cell 65:145-161(1991).
RN [6]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Essential for the control of the cell cycle at the G2/M
CC (mitosis) transition. Interacts with the CDC2 protein kinase to form
CC MPF. G2/M cyclins accumulate steadily during G2 and are abruptly
CC destroyed at mitosis.
CC -!- MISCELLANEOUS: Present with 98 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X69426; CAA49202.1; -; Genomic_DNA.
DR EMBL; M80303; AAA73136.1; -; Genomic_DNA.
DR EMBL; U14913; AAB67425.1; -; Genomic_DNA.
DR EMBL; BK006945; DAA09527.1; -; Genomic_DNA.
DR PIR; B60048; B60048.
DR RefSeq; NP_013311.1; NM_001182097.1.
DR AlphaFoldDB; P24871; -.
DR SMR; P24871; -.
DR BioGRID; 31478; 102.
DR ComplexPortal; CPX-337; CLB4-CDC28 kinase complex.
DR DIP; DIP-2268N; -.
DR IntAct; P24871; 3.
DR MINT; P24871; -.
DR STRING; 4932.YLR210W; -.
DR iPTMnet; P24871; -.
DR PaxDb; P24871; -.
DR PRIDE; P24871; -.
DR EnsemblFungi; YLR210W_mRNA; YLR210W; YLR210W.
DR GeneID; 850907; -.
DR KEGG; sce:YLR210W; -.
DR SGD; S000004200; CLB4.
DR VEuPathDB; FungiDB:YLR210W; -.
DR eggNOG; KOG0653; Eukaryota.
DR GeneTree; ENSGT00940000168350; -.
DR HOGENOM; CLU_020695_12_1_1; -.
DR InParanoid; P24871; -.
DR OMA; YMLENTY; -.
DR BioCyc; YEAST:G3O-32327-MON; -.
DR PRO; PR:P24871; -.
DR Proteomes; UP000002311; Chromosome XII.
DR RNAct; P24871; protein.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:SGD.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IMP:SGD.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0010696; P:positive regulation of mitotic spindle pole body separation; IGI:SGD.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IMP:SGD.
DR GO; GO:1901673; P:regulation of mitotic spindle assembly; IGI:SGD.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Mitosis; Reference proteome.
FT CHAIN 1..460
FT /note="G2/mitotic-specific cyclin-4"
FT /id="PRO_0000080406"
FT CONFLICT 255
FT /note="Q -> R (in Ref. 5; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 318
FT /note="D -> S (in Ref. 5; no nucleotide entry)"
FT /evidence="ECO:0000305"
FT CONFLICT 328
FT /note="I -> T (in Ref. 5; no nucleotide entry)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 460 AA; 53853 MW; 2BAFCEC706F2FBA2 CRC64;
MMLEGYTVQP PQSTLIGDIE IQDENANQEV KNVLYQGVQK GIKRLEKRQR RVALGDVTSQ
KANKIHNAIH NKFHQTKNNF EIENIRSSAL VKEQQRDVRH EDSDYFLIDS SEGSSTDDEQ
VNEDAIDDLL SRRVNDQQIQ ADEVYEDFDG EMQDVIEEDV DSQIEPLSPI NNDEIQTELD
RAFEKYFRSV PNPLDDDTHD VVMVVEYASD IFYYLRELEV KYRPNPYYMQ NQVELTWPFR
RTMIDWLVQL HFRFQLLPET LYLTINIVDR FLSKKTVTLN RFQLVGVSAL FIAAKFEEIN
CPTLDDLVYM LENTYTRDDI IRAEQYMIDT LEFEIGWPGP MPFLRRISKA DDYDFEPRTL
AKYLLETTIV EPKLVAAAPS WLAAGAYFLS RTILGSNDWS LKHVFYSGYT SSQIIPLASL
ILENCKNASR RHHSIWKKYF DQKHYRCSQI VEEWIVSTEA
