CG445_DROME
ID CG445_DROME Reviewed; 111 AA.
AC P22978; F0J880; Q0E8G7; Q9VSX0;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1991, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Rhodanese domain-containing protein CG4456 {ECO:0000305};
DE AltName: Full=Heat shock protein 67B2 {ECO:0000312|FlyBase:FBgn0001228};
GN ORFNames=CG4456 {ECO:0000312|FlyBase:FBgn0001228};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND DEVELOPMENTAL STAGE.
RX PubMed=2454316; DOI=10.1016/0022-2836(88)90332-4;
RA Pauli D., Tonka C.H., Ayme-Southgate A.;
RT "An unusual split Drosophila heat shock gene expressed during
RT embryogenesis, pupation and in testis.";
RL J. Mol. Biol. 200:47-53(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RA Carlson J., Booth B., Frise E., Park S., Wan K., Yu C., Celniker S.;
RL Submitted (FEB-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- DEVELOPMENTAL STAGE: Expressed during embryogenesis and pupation.
CC {ECO:0000269|PubMed:2454316}.
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DR EMBL; X07311; CAA30276.1; -; Genomic_DNA.
DR EMBL; AE014296; AAN11961.1; -; Genomic_DNA.
DR EMBL; AY060412; ADY17793.1; -; mRNA.
DR PIR; S00688; S00688.
DR RefSeq; NP_001027116.1; NM_001031945.2.
DR RefSeq; NP_001027117.1; NM_001031946.2.
DR RefSeq; NP_001189076.1; NM_001202147.1.
DR RefSeq; NP_001189077.1; NM_001202148.2.
DR AlphaFoldDB; P22978; -.
DR SMR; P22978; -.
DR STRING; 7227.FBpp0292525; -.
DR PaxDb; P22978; -.
DR DNASU; 3771872; -.
DR EnsemblMetazoa; FBtr0100653; FBpp0100114; FBgn0001228.
DR EnsemblMetazoa; FBtr0100655; FBpp0100115; FBgn0001228.
DR EnsemblMetazoa; FBtr0303473; FBpp0292525; FBgn0001228.
DR EnsemblMetazoa; FBtr0303474; FBpp0292526; FBgn0001228.
DR GeneID; 3771872; -.
DR KEGG; dme:Dmel_CG4456; -.
DR FlyBase; FBgn0001228; CG4456.
DR VEuPathDB; VectorBase:FBgn0001228; -.
DR eggNOG; KOG1530; Eukaryota.
DR GeneTree; ENSGT00940000163155; -.
DR HOGENOM; CLU_089574_0_2_1; -.
DR InParanoid; P22978; -.
DR OMA; FFCQMGR; -.
DR PhylomeDB; P22978; -.
DR BioGRID-ORCS; 3771872; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 3771872; -.
DR PRO; PR:P22978; -.
DR Proteomes; UP000000803; Chromosome 3L.
DR Bgee; FBgn0001228; Expressed in Malpighian tubule and 14 other tissues.
DR ExpressionAtlas; P22978; baseline.
DR Genevisible; P22978; DM.
DR Gene3D; 3.40.250.10; -; 1.
DR InterPro; IPR001763; Rhodanese-like_dom.
DR InterPro; IPR036873; Rhodanese-like_dom_sf.
DR Pfam; PF00581; Rhodanese; 1.
DR SMART; SM00450; RHOD; 1.
DR SUPFAM; SSF52821; SSF52821; 1.
DR PROSITE; PS50206; RHODANESE_3; 1.
PE 2: Evidence at transcript level;
KW Reference proteome; Stress response.
FT CHAIN 1..111
FT /note="Rhodanese domain-containing protein CG4456"
FT /id="PRO_0000084076"
FT DOMAIN 12..110
FT /note="Rhodanese"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00173"
SQ SEQUENCE 111 AA; 12614 MW; 9D04C1BCE0986658 CRC64;
MATYEQVKDV PNHPDVYLID VRRKEELQQT GFIPASINIP LDELDKALNL DGSAFKNKYG
RSKPEKQSPI IFTCRSGNRV LEAEKIAKSQ GYSNVVIYKG SWNEWAQKEG L
