ID   CGA2_HELPX              Reviewed;        1182 AA.
AC   P55746;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Cytotoxicity-associated immunodominant antigen;
DE   AltName: Full=120 kDa protein;
GN   Name=cagA; Synonyms=cai;
OS   Helicobacter pylori (Campylobacter pylori).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=210;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 53726 / 84-183;
RX   PubMed=8478069; DOI=10.1128/iai.61.5.1799-1809.1993;
RA   Tummuru M.K.R., Cover T.L., Blaser M.J.;
RT   "Cloning and expression of a high-molecular-mass major antigen of
RT   Helicobacter pylori: evidence of linkage to cytotoxin production.";
RL   Infect. Immun. 61:1799-1809(1993).
CC   -!- FUNCTION: May be necessary for the transcription, folding, export, or
CC       function of the cytotoxin.
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DR   EMBL; L11714; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P55746; -.
DR   SMR; P55746; -.
DR   GO; GO:0019534; F:toxin transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR005169; CagA_C.
DR   InterPro; IPR045157; CagA_N.
DR   InterPro; IPR004355; IVSec_CagA.
DR   Pfam; PF03507; CagA; 2.
DR   Pfam; PF18971; CagA_N; 1.
DR   PRINTS; PR01553; TYPE4SSCAGA.
PE   4: Predicted;
FT   CHAIN           1..1182
FT                   /note="Cytotoxicity-associated immunodominant antigen"
FT                   /id="PRO_0000089594"
SQ   SEQUENCE   1182 AA;  131504 MW;  C916817E2EE57BB4 CRC64;
     MTNETIDQQP QTEAAFNPQQ FINNLQVAFL KVDNAVASYD PDQKPIVDKN DRDNRQAFEG
     ISQLREEYSN KAIKNPTKKN QYFSDFINKS NDLINKDNLI VVESSTKSFQ KFGDQRYRIF
     TSWVSHQNDP SKINTRCIRN FMEHTIQPPI PDDKEKAEFL KSAKQSFAGI IIGNQIRTDQ
     KFMGVFDESL KERQEAEKNG GPTGGDWLDI FLSFIFDKKQ SSDVKEAINQ EPLPHVQPDI
     ATSTTHIQGL PPESRDLLDE RGNFSKFTLG DMEMLDVEGV ADMDPNYKFN QLLIHNNTLS
     SVLMGSHDGI EPEKVSLLYA GNGGFGAKHD WNATVGYKDQ QGNNVATIIN VHMKNGSGLV
     IAGGEKGINN PSFYLYKEDQ LTGSQRALSQ EEIQNKIDFM EFLAQNNAKL DSLSEKEKEK
     FRNEIKDFQK DSKPYLDALG NDRIAFVSKK DPKHSALITE FNKGDLSYTL KVMGKKQIKA
     LDREKNVTLQ GNLKHDGVMF VNYSNFKYTN ASKSPNKGVG VTNGVSHLEA GFSKVAVFNL
     PNLNNLAITS VVRRDLEDKL IAKGLSPQEA NKLVKDFLSS NKELVGKALN FNKAVAEAKN
     TGNYDEVKRA QKDLEKSLKK REHLEKGDVA KNLESKSGNK NKMEAKAQAN SQKDEIFALI
     NKEANRDARA IAYAQNLKGI KRELSDKLEN INKDLKDFSK SFDGFKNGKN KDFSKAEETL
     KALKGSVKDL GINPEWISKV ENLNAALNEF KNGKNKDFSK VTQAKSDQEN SIKDVIINQK
     ITDKVDELNQ AVSVAKIACD FSGVEQALAD LKNFSKEQLA QQAQKNESFN VGKSEIYQSV
     KNGVNGTLVG NGLSGIEATA LAKNFSDIKK ELNEKFKNFN NNNNNGLKNG GEPIYAQVNK
     KKTGQVASPE EPIYAQVAKK VTKKIDQLNQ AATSGFGGVG QAGFPLKRHD KVEDLSKVGR
     SVSPEPIYAT IDDLGGSFPL KRHDKVDDLS KVGLSRNQEL TQKIDNLSQA VSEAKAGFFG
     NLEQTIDKLK DFTKNNPVNL WAESAKKVPA SLSAKLDNYA TNSHTRINSN IQNGAINEKA
     TGTERQKNPE WLKLVNDKIV AHNVGSVPLS EYDNIGFSQK NMKDYSDSFK FSTKLNNAVK
     DIKSGFTQFL ANAFSTGYYS MARENAEHGI KNANTKGGFQ KS