CGB2_HUMAN
ID CGB2_HUMAN Reviewed; 163 AA.
AC Q6NT52; B9ZVM5; H9KV56;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-MAR-2018, sequence version 5.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Choriogonadotropin subunit beta variant 2;
DE Flags: Precursor;
GN Name=CGB2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=18048458; DOI=10.1093/molehr/gam082;
RA Rull K., Hallast P., Uuskula L., Jackson J., Punab M., Salumets A.,
RA Campbell R.K., Laan M.;
RT "Fine-scale quantification of HCG beta gene transcription in human
RT trophoblastic and non-malignant non-trophoblastic tissues.";
RL Mol. Hum. Reprod. 14:23-31(2008).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP MISCELLANEOUS.
RX PubMed=11861891; DOI=10.1093/oxfordjournals.molbev.a004085;
RA Maston G.A., Ruvolo M.;
RT "Chorionic gonadotropin has a recent origin within primates and an
RT evolutionary history of selection.";
RL Mol. Biol. Evol. 19:320-335(2002).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=16123088; DOI=10.1093/humrep/dei261;
RA Rull K., Laan M.;
RT "Expression of beta-subunit of HCG genes during normal and failed
RT pregnancy.";
RL Hum. Reprod. 20:3360-3368(2005).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed in placenta, testis and pituitary.
CC {ECO:0000269|PubMed:16123088, ECO:0000269|PubMed:18048458}.
CC -!- MISCELLANEOUS: Encoded by a cluster of genes that have evolved by
CC duplication from LHB. HCG-beta is encoded by six non-allelic genes
CC (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5,
CC CGB7 and CGB8. Two specific hCGb proteins that differ by three amino
CC acids in positions 2,4 and 117 have been described: type 1 (CGB7) and
CC type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common
CC ancestor of the anthropoid primates. {ECO:0000269|PubMed:11861891}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH69367.2; Type=Erroneous translation; Note=Wrong choice of frame.; Evidence={ECO:0000305};
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DR EMBL; AC008687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC069367; AAH69367.2; ALT_SEQ; mRNA.
DR CCDS; CCDS12750.2; -.
DR RefSeq; NP_203696.2; NM_033378.1.
DR AlphaFoldDB; Q6NT52; -.
DR SMR; Q6NT52; -.
DR IntAct; Q6NT52; 14.
DR STRING; 9606.ENSP00000352295; -.
DR GlyGen; Q6NT52; 2 sites.
DR PhosphoSitePlus; Q6NT52; -.
DR BioMuta; CGB2; -.
DR DMDM; 281185508; -.
DR MassIVE; Q6NT52; -.
DR MaxQB; Q6NT52; -.
DR PaxDb; Q6NT52; -.
DR PeptideAtlas; Q6NT52; -.
DR PRIDE; Q6NT52; -.
DR ProteomicsDB; 46213; -.
DR Antibodypedia; 31875; 83 antibodies from 11 providers.
DR DNASU; 114336; -.
DR Ensembl; ENST00000359342.7; ENSP00000352295.6; ENSG00000104818.15.
DR GeneID; 114336; -.
DR KEGG; hsa:114336; -.
DR MANE-Select; ENST00000359342.7; ENSP00000352295.6; NM_033378.2; NP_203696.2.
DR CTD; 114336; -.
DR DisGeNET; 114336; -.
DR GeneCards; CGB2; -.
DR HGNC; HGNC:16722; CGB2.
DR HPA; ENSG00000104818; Tissue enhanced (testis).
DR MIM; 608824; gene.
DR neXtProt; NX_Q6NT52; -.
DR OpenTargets; ENSG00000104818; -.
DR VEuPathDB; HostDB:ENSG00000104818; -.
DR eggNOG; ENOG502S49V; Eukaryota.
DR GeneTree; ENSGT00940000163162; -.
DR InParanoid; Q6NT52; -.
DR OMA; CTYRDFY; -.
DR OrthoDB; 1362225at2759; -.
DR PhylomeDB; Q6NT52; -.
DR TreeFam; TF332940; -.
DR PathwayCommons; Q6NT52; -.
DR SignaLink; Q6NT52; -.
DR BioGRID-ORCS; 114336; 26 hits in 608 CRISPR screens.
DR GenomeRNAi; 114336; -.
DR Pharos; Q6NT52; Tdark.
DR PRO; PR:Q6NT52; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6NT52; protein.
DR Bgee; ENSG00000104818; Expressed in right testis and 29 other tissues.
DR ExpressionAtlas; Q6NT52; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; IMP:AgBase.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..163
FT /note="Choriogonadotropin subunit beta variant 2"
FT /evidence="ECO:0000255"
FT /id="PRO_0000342549"
FT REGION 129..163
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..163
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 31
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 48
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 27..75
FT /evidence="ECO:0000250"
FT DISULFID 41..90
FT /evidence="ECO:0000250"
FT DISULFID 44..128
FT /evidence="ECO:0000250"
FT DISULFID 52..106
FT /evidence="ECO:0000250"
FT DISULFID 56..108
FT /evidence="ECO:0000250"
FT DISULFID 111..118
FT /evidence="ECO:0000250"
SQ SEQUENCE 163 AA; 17374 MW; 823CEF334B9183F6 CRC64;
MSKGLLLLLL LSMGGTWASK EPLRPRCRPI NATLAVEKEG CPVCITVNTT ICAGYCPTMT
RVLQGVLPAL PQVVCNYRDV RFESIRLPGC PRGVNPVVSY AVALSCQCAL CRRSTTDCGG
PKDHPLTCDD PRFQASSSSK APPPSLPSPS RLPGPSDTPI LPQ
