CGB7_HUMAN
ID CGB7_HUMAN Reviewed; 165 AA.
AC P0DN87; A1A5E0; B9ZVP5; P01233; Q13991; Q14000; Q3KPI3; Q3SY41; Q8WTT5;
AC Q8WXL1; Q8WXL2; Q8WXL3; Q8WXL4;
DT 11-MAY-2016, integrated into UniProtKB/Swiss-Prot.
DT 11-MAY-2016, sequence version 1.
DT 03-AUG-2022, entry version 35.
DE RecName: Full=Choriogonadotropin subunit beta 7;
DE Flags: Precursor;
GN Name=CGB7 {ECO:0000312|HGNC:HGNC:16451};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP MISCELLANEOUS.
RX PubMed=11861891; DOI=10.1093/oxfordjournals.molbev.a004085;
RA Maston G.A., Ruvolo M.;
RT "Chorionic gonadotropin has a recent origin within primates and an
RT evolutionary history of selection.";
RL Mol. Biol. Evol. 19:320-335(2002).
RN [5]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=16123088; DOI=10.1093/humrep/dei261;
RA Rull K., Laan M.;
RT "Expression of beta-subunit of HCG genes during normal and failed
RT pregnancy.";
RL Hum. Reprod. 20:3360-3368(2005).
CC -!- FUNCTION: Beta subunit of the human chorionic gonadotropin (hCG). hCG
CC is a complex glycoprotein composed of two glycosylated subunits alpha
CC and beta which are non-covalently associated. The alpha subunit is
CC identical to those in the pituitary gonadotropin hormones (LH, FSH and
CC TSH). The beta subunits are distinct in each of the hormones and confer
CC receptor and biological specificity. Has an essential role for
CC pregnancy and maternal adaptation. Stimulates the ovaries to synthesize
CC the steroids that are essential for the maintenance of pregnancy.
CC {ECO:0000305}.
CC -!- SUBUNIT: Heterodimer of a common alpha chain identical in LH, FSH, TSH
CC and HCG and a unique beta chain distinct in each of the hormones and
CC confers receptor and biological specificity. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:16123088}.
CC -!- TISSUE SPECIFICITY: High expression in the placenta throughout
CC pregnancy. {ECO:0000269|PubMed:16123088}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the placenta throughout pregnancy.
CC {ECO:0000269|PubMed:16123088}.
CC -!- MISCELLANEOUS: Encoded by a cluster of genes that have evolved by
CC duplication from LHB. HCG-beta is encoded by six non-allelic genes
CC (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5,
CC CGB7 and CGB8. Two specific hCGb proteins that differ by three amino
CC acids in positions 2,4 and 117 have been described: type 1 (CGB7) and
CC type 2 (CGB3, CGB5, CGB8). The CGB gene first arose in the common
CC ancestor of the anthropoid primates. {ECO:0000269|PubMed:11861891}.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; AK125108; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC008687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471177; EAW52439.1; -; Genomic_DNA.
DR CCDS; CCDS33071.1; -.
DR RefSeq; NP_149133.1; NM_033142.1.
DR RefSeq; XP_016882991.1; XM_017027502.1.
DR AlphaFoldDB; P0DN87; -.
DR SMR; P0DN87; -.
DR STRING; 9606.ENSP00000470813; -.
DR GlyGen; P0DN87; 6 sites.
DR BioMuta; CGB7; -.
DR MassIVE; P0DN87; -.
DR MaxQB; P0DN87; -.
DR PaxDb; P0DN87; -.
DR PeptideAtlas; P0DN87; -.
DR PRIDE; P0DN87; -.
DR Antibodypedia; 31888; 52 antibodies from 14 providers.
DR DNASU; 94027; -.
DR Ensembl; ENST00000596965.5; ENSP00000469076.1; ENSG00000196337.13.
DR Ensembl; ENST00000597853.5; ENSP00000470813.1; ENSG00000196337.13.
DR Ensembl; ENST00000684222.1; ENSP00000507822.1; ENSG00000196337.13.
DR GeneID; 94027; -.
DR KEGG; hsa:94027; -.
DR MANE-Select; ENST00000684222.1; ENSP00000507822.1; NM_001385261.1; NP_001372190.1.
DR CTD; 94027; -.
DR DisGeNET; 94027; -.
DR GeneCards; CGB7; -.
DR HGNC; HGNC:16451; CGB7.
DR HPA; ENSG00000196337; Tissue enhanced (prostate, skin).
DR MIM; 608826; gene.
DR neXtProt; NX_P0DN87; -.
DR OpenTargets; ENSG00000196337; -.
DR VEuPathDB; HostDB:ENSG00000196337; -.
DR eggNOG; ENOG502S49V; Eukaryota.
DR GeneTree; ENSGT00940000163162; -.
DR OMA; FCITTTS; -.
DR OrthoDB; 1362225at2759; -.
DR PhylomeDB; P0DN87; -.
DR PathwayCommons; P0DN87; -.
DR BioGRID-ORCS; 94027; 10 hits in 623 CRISPR screens.
DR ChiTaRS; CGB7; human.
DR GenomeRNAi; 94027; -.
DR Pharos; P0DN87; Tdark.
DR PRO; PR:P0DN87; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; P0DN87; protein.
DR Bgee; ENSG00000196337; Expressed in lower esophagus mucosa and 61 other tissues.
DR ExpressionAtlas; P0DN87; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0005179; F:hormone activity; TAS:ProtInc.
DR GO; GO:0006915; P:apoptotic process; TAS:ProtInc.
DR GO; GO:0007267; P:cell-cell signaling; TAS:ProtInc.
DR GO; GO:0007292; P:female gamete generation; TAS:ProtInc.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; TAS:ProtInc.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT CHAIN 21..165
FT /note="Choriogonadotropin subunit beta 7"
FT /id="PRO_0000436152"
FT REGION 131..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 144..165
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT CARBOHYD 141
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT CARBOHYD 147
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT CARBOHYD 152
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT CARBOHYD 158
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT DISULFID 29..77
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT DISULFID 43..92
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT DISULFID 46..130
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT DISULFID 54..108
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT DISULFID 58..110
FT /evidence="ECO:0000250|UniProtKB:P01233"
FT DISULFID 113..120
FT /evidence="ECO:0000250|UniProtKB:P01233"
SQ SEQUENCE 165 AA; 17757 MW; B9C34C7B8EDD469F CRC64;
MEMFQGLLLL LLLSMGGTWA SREMLRPRCR PINATLAVEK EGCPVCITVN TTICAGYCPT
MTRVLQGVLP ALPQVVCNYR DVRFESIRLP GCPRGVNPVV SYAVALSCQC ALCRRSTTDC
GGPKDHPLTC DDPRFQASSS SKAPPPSLPS PSRLPGPSDT PILPQ
