CGBP1_MOUSE
ID CGBP1_MOUSE Reviewed; 167 AA.
AC Q8BHG9; Q8K2K1;
DT 17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=CGG triplet repeat-binding protein 1;
DE Short=CGG-binding protein 1;
DE AltName: Full=20 kDa CGG-binding protein;
DE AltName: Full=p20-CGGBP DNA-binding protein;
GN Name=Cggbp1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=14667814; DOI=10.1016/s0888-7543(03)00212-x;
RA Naumann F., Remus R., Schmitz B., Doerfler W.;
RT "Gene structure and expression of the 5'-(CGG)(n)-3'-binding protein
RT (CGGBP1).";
RL Genomics 83:106-118(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo, Heart, and Spinal cord;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and Czech II; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Kidney, Lung, Pancreas, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Binds to nonmethylated 5'-d(CGG)(n)-3' trinucleotide repeats
CC in the FMR1 promoter. May play a role in regulating FMR1 promoter (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- MISCELLANEOUS: Binding is severely inhibited by complete or partial
CC cytosine-specific DNA methylation of the binding motif. {ECO:0000250}.
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DR EMBL; AY189895; AAO32829.1; -; Genomic_DNA.
DR EMBL; AK049631; BAC33847.1; -; mRNA.
DR EMBL; AK052195; BAC34877.1; -; mRNA.
DR EMBL; AK083450; BAC38920.1; -; mRNA.
DR EMBL; BC031191; AAH31191.1; -; mRNA.
DR EMBL; BC043097; AAH43097.1; -; mRNA.
DR EMBL; BC057053; AAH57053.1; -; mRNA.
DR CCDS; CCDS28266.1; -.
DR RefSeq; NP_848762.1; NM_178647.2.
DR RefSeq; XP_006521721.1; XM_006521658.2.
DR AlphaFoldDB; Q8BHG9; -.
DR SMR; Q8BHG9; -.
DR BioGRID; 222999; 1.
DR IntAct; Q8BHG9; 1.
DR STRING; 10090.ENSMUSP00000065845; -.
DR iPTMnet; Q8BHG9; -.
DR PhosphoSitePlus; Q8BHG9; -.
DR EPD; Q8BHG9; -.
DR jPOST; Q8BHG9; -.
DR MaxQB; Q8BHG9; -.
DR PaxDb; Q8BHG9; -.
DR PeptideAtlas; Q8BHG9; -.
DR PRIDE; Q8BHG9; -.
DR ProteomicsDB; 281656; -.
DR Antibodypedia; 32047; 232 antibodies from 29 providers.
DR DNASU; 106143; -.
DR Ensembl; ENSMUST00000067744; ENSMUSP00000065845; ENSMUSG00000054604.
DR GeneID; 106143; -.
DR KEGG; mmu:106143; -.
DR UCSC; uc007zqe.1; mouse.
DR CTD; 8545; -.
DR MGI; MGI:2146370; Cggbp1.
DR VEuPathDB; HostDB:ENSMUSG00000054604; -.
DR eggNOG; ENOG502RXX8; Eukaryota.
DR GeneTree; ENSGT00390000017898; -.
DR HOGENOM; CLU_132996_0_0_1; -.
DR InParanoid; Q8BHG9; -.
DR OMA; TYLPDGY; -.
DR OrthoDB; 1312529at2759; -.
DR PhylomeDB; Q8BHG9; -.
DR TreeFam; TF335518; -.
DR BioGRID-ORCS; 106143; 6 hits in 73 CRISPR screens.
DR ChiTaRS; Cggbp1; mouse.
DR PRO; PR:Q8BHG9; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q8BHG9; protein.
DR Bgee; ENSMUSG00000054604; Expressed in medial ganglionic eminence and 251 other tissues.
DR Genevisible; Q8BHG9; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISO:MGI.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; ISO:MGI.
DR GO; GO:0003690; F:double-stranded DNA binding; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0010468; P:regulation of gene expression; IBA:GO_Central.
DR GO; GO:0040029; P:regulation of gene expression, epigenetic; ISO:MGI.
DR InterPro; IPR033375; Cggbp1.
DR PANTHER; PTHR32344; PTHR32344; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..167
FT /note="CGG triplet repeat-binding protein 1"
FT /id="PRO_0000252416"
FT REGION 65..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 80..84
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 65..82
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 56
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UFW8"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UFW8"
SQ SEQUENCE 167 AA; 18761 MW; 1FE797D198A0B7BD CRC64;
MERFVVTAPP ARNRSKTALY VTPLDRVTEF GGELHEDGGK LFCTSCNVVL NHVRKSAISD
HLKSKTHTKR KAEFEEQNVR KKQRPLTASL QCNSPAQTEK ASVIQDFVKM CLEANIPLEK
ADHPAVRAFL SRHVKNGGSI PKSDQLRRAY LPDGYENENQ LLSSQDC
