ID   CGHB_AOTNA              Reviewed;         164 AA.
AC   Q3HRV3;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   25-MAY-2022, entry version 55.
DE   RecName: Full=Choriogonadotropin subunit beta;
DE            Short=CG-beta;
DE   AltName: Full=Chorionic gonadotrophin chain beta;
DE   Flags: Precursor;
GN   Name=CGB;
OS   Aotus nancymaae (Ma's night monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae;
OC   Aotus.
OX   NCBI_TaxID=37293;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=17897645; DOI=10.1016/j.ygcen.2007.08.004;
RA   Scammell J.G., Funkhouser J.D., Moyer F.S., Gibson S.V., Willis D.L.;
RT   "Molecular cloning of pituitary glycoprotein alpha-subunit and follicle
RT   stimulating hormone and chorionic gonadotropin beta-subunits from New World
RT   squirrel monkey and owl monkey.";
RL   Gen. Comp. Endocrinol. 155:534-541(2008).
CC   -!- FUNCTION: Stimulates the ovaries to synthesize the steroids that are
CC       essential for the maintenance of pregnancy. {ECO:0000250}.
CC   -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC       which confers biological specificity to thyrotropin, lutropin,
CC       follitropin and gonadotropin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC       {ECO:0000305}.
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DR   EMBL; DQ200808; ABA54987.1; -; mRNA.
DR   RefSeq; NP_001295451.1; NM_001308522.1.
DR   AlphaFoldDB; Q3HRV3; -.
DR   SMR; Q3HRV3; -.
DR   STRING; 37293.ENSANAP00000015832; -.
DR   Ensembl; ENSANAT00000033677; ENSANAP00000015834; ENSANAG00000025792.
DR   GeneID; 105722736; -.
DR   GeneTree; ENSGT00940000163162; -.
DR   OMA; NSICAGY; -.
DR   Proteomes; UP000233020; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   CDD; cd00069; GHB_like; 1.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR006208; Glyco_hormone_CN.
DR   InterPro; IPR001545; Gonadotropin_bsu.
DR   InterPro; IPR018245; Gonadotropin_bsu_CS.
DR   PANTHER; PTHR11515; PTHR11515; 1.
DR   Pfam; PF00007; Cys_knot; 1.
DR   SMART; SM00068; GHB; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR   PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000250"
FT   CHAIN           21..164
FT                   /note="Choriogonadotropin subunit beta"
FT                   /id="PRO_0000253468"
FT   REGION          133..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        50
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        140
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        146
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        151
FT                   /note="O-linked (GalNAc...) serine"
FT                   /evidence="ECO:0000250"
FT   DISULFID        29..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        43..92
FT                   /evidence="ECO:0000250"
FT   DISULFID        46..130
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        58..110
FT                   /evidence="ECO:0000250"
FT   DISULFID        113..120
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   164 AA;  17824 MW;  1631D3C2A6B7F047 CRC64;
     MEMLQGLLLC LLLSTGGAWA SNEPLRPLCR PTHAILAAEK EGCPVCVAFN TTICAGYCSS
     MVRVLQTVMP PLPQLVCNYH ELRFTSVRLP GCRRGVNPVV YFPVAVSCRC ALCRRSYSDC
     GNLKSEPLGC DYHTSQDSSS KDPPRNLTSP SQLPEPADAP LVPQ