CGHB_PAPAN
ID CGHB_PAPAN Reviewed; 165 AA.
AC P07434;
DT 01-APR-1988, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1988, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Choriogonadotropin subunit beta;
DE Short=CG-beta;
DE AltName: Full=Chorionic gonadotrophin chain beta;
DE Flags: Precursor;
GN Name=CGB;
OS Papio anubis (Olive baboon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Papio.
OX NCBI_TaxID=9555;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2433190; DOI=10.1016/0378-1119(86)90400-2;
RA Crawford R.J., Tregear G.W., Niall H.D.;
RT "The nucleotide sequences of baboon chorionic gonadotropin beta-subunit
RT genes have diverged from the human.";
RL Gene 46:161-169(1986).
CC -!- FUNCTION: Stimulates the ovaries to synthesize the steroids that are
CC essential for the maintenance of pregnancy.
CC -!- SUBUNIT: Heterodimer of a common alpha chain and a unique beta chain
CC which confers biological specificity to thyrotropin, lutropin,
CC follitropin and gonadotropin.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Placenta.
CC -!- MISCELLANEOUS: There are at least five copies of CG-related genes and
CC at least two of these are expressed in the baboon placenta.
CC -!- SIMILARITY: Belongs to the glycoprotein hormones subunit beta family.
CC {ECO:0000305}.
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DR EMBL; M14966; AAA35383.1; -; mRNA.
DR PIR; A25808; KTBAB.
DR RefSeq; NP_001106126.1; NM_001112656.1.
DR AlphaFoldDB; P07434; -.
DR SMR; P07434; -.
DR STRING; 9555.ENSPANP00000010071; -.
DR GeneID; 100126757; -.
DR CTD; 100126757; -.
DR eggNOG; ENOG502S49V; Eukaryota.
DR OrthoDB; 1362225at2759; -.
DR Proteomes; UP000028761; Unplaced.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR CDD; cd00069; GHB_like; 1.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR006208; Glyco_hormone_CN.
DR InterPro; IPR001545; Gonadotropin_bsu.
DR InterPro; IPR018245; Gonadotropin_bsu_CS.
DR PANTHER; PTHR11515; PTHR11515; 1.
DR Pfam; PF00007; Cys_knot; 1.
DR SMART; SM00068; GHB; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00261; GLYCO_HORMONE_BETA_1; 1.
DR PROSITE; PS00689; GLYCO_HORMONE_BETA_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Hormone; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000250"
FT CHAIN 21..165
FT /note="Choriogonadotropin subunit beta"
FT /id="PRO_0000011677"
FT REGION 131..165
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 33
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 50
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000250"
FT CARBOHYD 141
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250"
FT CARBOHYD 147
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250"
FT CARBOHYD 152
FT /note="O-linked (GalNAc...) serine"
FT /evidence="ECO:0000250"
FT DISULFID 29..77
FT /evidence="ECO:0000250"
FT DISULFID 43..92
FT /evidence="ECO:0000250"
FT DISULFID 46..130
FT /evidence="ECO:0000250"
FT DISULFID 54..108
FT /evidence="ECO:0000250"
FT DISULFID 58..110
FT /evidence="ECO:0000250"
FT DISULFID 113..120
FT /evidence="ECO:0000250"
SQ SEQUENCE 165 AA; 17593 MW; 36D3E207A9F1E1C3 CRC64;
METLQGLLLW LLLSMGGAQA SREPLRPLCR PINATLAAEK EACPVCVTVN TTICAGYCPT
MMRVLQAVLP PVPQVVCNYR EVRFESIRLP GCPPGVDPMV SVPVALSCRC ALCRRSTSDC
GGPKDHPLTC DDPNLQASSS SKDPPPSPPS PSRLLEPAGT PFLPQ
