ID   CGHF_CHAGB              Reviewed;         528 AA.
AC   Q2HBN1;
DT   29-SEP-2021, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Transcription factor cghF {ECO:0000303|PubMed:26360642};
DE   AltName: Full=Sch210972 biosynthesis cluster protein F {ECO:0000303|PubMed:26360642};
DE   Flags: Fragment;
GN   Name=cghF {ECO:0000303|PubMed:26360642}; ORFNames=CHGG_02373;
OS   Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 /
OS   NRRL 1970) (Soil fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Chaetomium.
OX   NCBI_TaxID=306901;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970;
RX   PubMed=25720678; DOI=10.1128/genomea.00021-15;
RA   Cuomo C.A., Untereiner W.A., Ma L.-J., Grabherr M., Birren B.W.;
RT   "Draft genome sequence of the cellulolytic fungus Chaetomium globosum.";
RL   Genome Announc. 3:E0002115-E0002115(2015).
RN   [2]
RP   FUNCTION.
RX   PubMed=26360642; DOI=10.1002/cbic.201500386;
RA   Sato M., Yagishita F., Mino T., Uchiyama N., Patel A., Chooi Y.H., Goda Y.,
RA   Xu W., Noguchi H., Yamamoto T., Hotta K., Houk K.N., Tang Y., Watanabe K.;
RT   "Involvement of lipocalin-like CghA in decalin-forming stereoselective
RT   intramolecular [4+2] cycloaddition.";
RL   ChemBioChem 16:2294-2298(2015).
CC   -!- FUNCTION: Transcription factor that regulates the expression of the
CC       gene cluster that mediates the biosynthesis of the tetramic acid
CC       Sch210972, a potential anti-HIV fungal natural product that contains a
CC       decalin core. {ECO:0000305|PubMed:26360642}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305|PubMed:26360642}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CH408030; EAQ90438.1; -; Genomic_DNA.
DR   RefSeq; XP_001228889.1; XM_001228888.1.
DR   SMR; Q2HBN1; -.
DR   EnsemblFungi; EAQ90438; EAQ90438; CHGG_02373.
DR   GeneID; 4389927; -.
DR   eggNOG; ENOG502QSY9; Eukaryota.
DR   HOGENOM; CLU_007426_5_1_1; -.
DR   InParanoid; Q2HBN1; -.
DR   OMA; TIWLHRK; -.
DR   OrthoDB; 365037at2759; -.
DR   Proteomes; UP000001056; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
PE   4: Predicted;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation; Zinc.
FT   CHAIN           <1..528
FT                   /note="Transcription factor cghF"
FT                   /id="PRO_0000453350"
FT   REGION          232..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        233..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        249..263
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   528 AA;  59358 MW;  F542A2C1143E9ED5 CRC64;
     MREHSHGANY VSSVHWAAVL DSISELIDQC QEKEKEKKPV PEDGSIAPQI PGPRLLYEPV
     KETKAEILAS MPARTVVDRM VARYFNALGI APAILHSAQF LREYESFWKD PDATPFVWIG
     LLFSVICLAV QFQQPGEEAA EWSSLMRIRQ FHDRIVQCLV LGQYTRGGPY VVETMVNYCA
     SELCITKDTD VGPWLPLGIM VPLAVSRGYH RDPAGFPNIS PFAGEMRRRV ATPPNHATSS
     TPTSTRTPPT YHPHGPRPKS PLSSTPSPRT ESTKSAAPSR DLAADAHDRP YPEILALDKD
     LQTIETSLPP IFRWQPLSQS FMVPGQVLMF RLWLRLAVLR LVIWLHRKYL APAYSAAPYA
     YSRAACARAA LEIAEFQLLL HEETRPGGQL HQMRWMQSSL MQSTFLLGMS VACYWMQLTR
     TALPGADQDM EMRERIRDRL RDTYPLWLRC SAVSRDAREA AERLRQLPDL QGLLPDVEGQ
     LSAQESPGSG VPACWDIFHG TGRHARALDA VLGDMDRSRK TNADWARV