ID   CGL3_COPC7              Reviewed;         164 AA.
AC   A8N3G7;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Galectin-3;
DE   AltName: Full=Cgl-III;
DE   AltName: Full=Galectin III;
GN   Name=Cgl3; ORFNames=CC1G_00723;
OS   Coprinopsis cinerea (strain Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003)
OS   (Inky cap fungus) (Hormographiella aspergillata).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC   Agaricomycetidae; Agaricales; Psathyrellaceae; Coprinopsis.
OX   NCBI_TaxID=240176;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Okayama-7 / 130 / ATCC MYA-4618 / FGSC 9003;
RX   PubMed=20547848; DOI=10.1073/pnas.1003391107;
RA   Stajich J.E., Wilke S.K., Ahren D., Au C.H., Birren B.W., Borodovsky M.,
RA   Burns C., Canbaeck B., Casselton L.A., Cheng C.K., Deng J., Dietrich F.S.,
RA   Fargo D.C., Farman M.L., Gathman A.C., Goldberg J., Guigo R., Hoegger P.J.,
RA   Hooker J.B., Huggins A., James T.Y., Kamada T., Kilaru S., Kodira C.,
RA   Kuees U., Kupfer D., Kwan H.S., Lomsadze A., Li W., Lilly W.W., Ma L.-J.,
RA   Mackey A.J., Manning G., Martin F., Muraguchi H., Natvig D.O.,
RA   Palmerini H., Ramesh M.A., Rehmeyer C.J., Roe B.A., Shenoy N., Stanke M.,
RA   Ter-Hovhannisyan V., Tunlid A., Velagapudi R., Vision T.J., Zeng Q.,
RA   Zolan M.E., Pukkila P.J.;
RT   "Insights into evolution of multicellular fungi from the assembled
RT   chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus).";
RL   Proc. Natl. Acad. Sci. U.S.A. 107:11889-11894(2010).
CC   -!- FUNCTION: Binds lactose. May play a role in fruiting body formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homotetramer. Oligomerization is required for carbohydrate
CC       binding. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000250}. Secreted, cell wall {ECO:0000250}.
CC   -!- INDUCTION: Induced during fruiting body formation. {ECO:0000250}.
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DR   EMBL; AACS02000001; EAU92504.1; -; Genomic_DNA.
DR   RefSeq; XP_001829544.1; XM_001829492.2.
DR   AlphaFoldDB; A8N3G7; -.
DR   SMR; A8N3G7; -.
DR   EnsemblFungi; EAU92504; EAU92504; CC1G_00723.
DR   GeneID; 6005975; -.
DR   KEGG; cci:CC1G_00723; -.
DR   VEuPathDB; FungiDB:CC1G_00723; -.
DR   eggNOG; ENOG502SSSF; Eukaryota.
DR   HOGENOM; CLU_117277_0_0_1; -.
DR   InParanoid; A8N3G7; -.
DR   OMA; ISIMDAN; -.
DR   OrthoDB; 1607245at2759; -.
DR   Proteomes; UP000001861; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:UniProtKB-KW.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001079; Galectin_CRD.
DR   Pfam; PF00337; Gal-bind_lectin; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS51304; GALECTIN; 1.
PE   3: Inferred from homology;
KW   Cell wall; Extracellular matrix; Fruiting body; Lectin; Reference proteome;
KW   Secreted.
FT   CHAIN           1..164
FT                   /note="Galectin-3"
FT                   /id="PRO_0000333264"
FT   DOMAIN          9..154
FT                   /note="Galectin"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00639"
FT   BINDING         60
FT                   /ligand="a carbohydrate"
FT                   /ligand_id="ChEBI:CHEBI:16646"
FT                   /evidence="ECO:0000250"
FT   BINDING         64
FT                   /ligand="a carbohydrate"
FT                   /ligand_id="ChEBI:CHEBI:16646"
FT                   /evidence="ECO:0000250"
FT   BINDING         73
FT                   /ligand="a carbohydrate"
FT                   /ligand_id="ChEBI:CHEBI:16646"
FT                   /evidence="ECO:0000250"
FT   BINDING         84
FT                   /ligand="a carbohydrate"
FT                   /ligand_id="ChEBI:CHEBI:16646"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   164 AA;  18721 MW;  582DFE1507E79917 CRC64;
     MFHILRLEST VDLSEPLKDN GIIVFQSDKL DLEPSPNLGP TGIDNTNVNL INAKGDVLLH
     IGIRRRENAF VFNSIPYGES RGPEERIPLE GTFGDRRDPS ITVFDHPDRY QIMIDYKTVY
     YYKKRLEGRC EKVSYKINEG QTPPFSDVLG VTVLYFANVM PRAN