CGP1_CAEEL
ID CGP1_CAEEL Reviewed; 613 AA.
AC Q18905; Q9UAZ4;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2002, sequence version 2.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=GTP-binding protein cgp-1;
GN Name=cgp-1; ORFNames=Y38C9A.2;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8524289; DOI=10.1128/mcb.16.1.130;
RA Huang Y.-J., Stoffel R., Tobler H., Mueller F.;
RT "A newly formed telomere in Ascaris suum does not exert a telomere position
RT effect on a nearby gene.";
RL Mol. Cell. Biol. 16:130-134(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. GTPBP1
CC subfamily. {ECO:0000255|PROSITE-ProRule:PRU01059}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; L40996; AAA86431.1; -; mRNA.
DR EMBL; FO081493; CCD71977.1; -; Genomic_DNA.
DR PIR; T34011; T34011.
DR PIR; T37295; T37295.
DR RefSeq; NP_503137.1; NM_070736.7.
DR AlphaFoldDB; Q18905; -.
DR SMR; Q18905; -.
DR BioGRID; 43615; 1.
DR STRING; 6239.Y38C9A.2.1; -.
DR iPTMnet; Q18905; -.
DR EPD; Q18905; -.
DR PaxDb; Q18905; -.
DR PeptideAtlas; Q18905; -.
DR EnsemblMetazoa; Y38C9A.2a.1; Y38C9A.2a.1; WBGene00000480.
DR GeneID; 178540; -.
DR KEGG; cel:CELE_Y38C9A.2; -.
DR UCSC; Y38C9A.2.1; c. elegans.
DR CTD; 178540; -.
DR WormBase; Y38C9A.2a; CE21577; WBGene00000480; cgp-1.
DR eggNOG; KOG0463; Eukaryota.
DR GeneTree; ENSGT00940000156054; -.
DR HOGENOM; CLU_012821_2_0_1; -.
DR InParanoid; Q18905; -.
DR OMA; HNNNLDW; -.
DR OrthoDB; 682656at2759; -.
DR PhylomeDB; Q18905; -.
DR PRO; PR:Q18905; -.
DR Proteomes; UP000001940; Chromosome V.
DR Bgee; WBGene00000480; Expressed in embryo and 4 other tissues.
DR ExpressionAtlas; Q18905; baseline and differential.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IBA:GO_Central.
DR GO; GO:0006414; P:translational elongation; IBA:GO_Central.
DR CDD; cd04165; GTPBP1_like; 1.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR039263; GTPB1.
DR InterPro; IPR035531; GTPBP1-like.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR PANTHER; PTHR43721:SF9; PTHR43721:SF9; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR SUPFAM; SSF50447; SSF50447; 1.
DR SUPFAM; SSF50465; SSF50465; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 2: Evidence at transcript level;
KW GTP-binding; Nucleotide-binding; Reference proteome.
FT CHAIN 1..613
FT /note="GTP-binding protein cgp-1"
FT /id="PRO_0000122473"
FT DOMAIN 138..367
FT /note="tr-type G"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 147..154
FT /note="G1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 186..190
FT /note="G2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 232..235
FT /note="G3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 288..291
FT /note="G4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 344..346
FT /note="G5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01059"
FT REGION 554..589
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 147..154
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 232..236
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT BINDING 288..291
FT /ligand="GTP"
FT /ligand_id="ChEBI:CHEBI:37565"
FT /evidence="ECO:0000255"
FT CONFLICT 69
FT /note="E -> R (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 238
FT /note="K -> I (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 248..253
FT /note="TGHMPD -> HRPYARN (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 296
FT /note="N -> Y (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 325
FT /note="V -> C (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 360
FT /note="I -> M (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 428..429
FT /note="MP -> CL (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 453
FT /note="K -> Q (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 507..511
FT /note="KEVLR -> RSAS (in Ref. 1; AAA86431)"
FT /evidence="ECO:0000305"
FT CONFLICT 585..613
FT /note="KPKEKIEKKLDALSIEQLTSAASTSTSST -> SQKKKSRRS (in Ref.
FT 1; AAA86431)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 67776 MW; B14304AF710494A6 CRC64;
MDRIQENQKK ATNLCELYAD GNDDDSEKEQ QDRGLDAQFL LRSTPEDVEK YMIHVRKQLM
EGEGECLVEL GAPINSNSKN PKSGLSEEDL DKAADAQLKI LEKIPAVGTK VIRRKQTGGG
SLFTEVWIIR DPPTEKDFIE ARVAVVGNVD AGKSTLLGVL THSALDDGRG AARTKLFRHK
HEFESGRTSS VGNDILGFDV HGNIVNKPDP HNHNLDWVQI GSDCAKLVTF IDLAGHEKYL
KTTIFGMTGH MPDYTMLMIG ANMGIIGTTK EHLSLALSLH VPVYLVVTKI DMCPANILEE
TMKNITRLVR SAKKLPILVR NMDDVVHAAV NFPSKKVCPI FQVSNVEGTN LPLLRQFLNI
VPLRRQLNEN DPAHFQIDDI YWVDGVGTIA SGTLLSGTIR LNDILLLGPT SNGDFMPIPI
KSIHRKRMPV GIVKCGQSAS FALKKIPKKD VRKGMVLVDP KVKPVASMVF EAEILVLHHP
TTIKPNYQAM LHIGSVRQTA TLVSMGKEVL RTGDRDKVQF KFIRQPEYIR PGTKMVFREG
RTKAVGTVSS VVPQESLAQQ RAKQKDGRQK QYGKKSMGPK PPNGKPKEKI EKKLDALSIE
QLTSAASTST SST
